RESUMO
Dermal fillers are highly favored around the globe as minimally invasive or nonsurgical procedures. Imatinib mesylate is the first-line treatment for patients diagnosed with chronic myeloid leukemia. However, some studies describe that imatinib mesylate may increase the tendency of skin fragility which can lead to easy bruising and hyperpigmentation after invasive skin procedures. Yet, to our knowledge, no studies have described any successful dermal filler injection performed on patients who are under imatinib mesylate treatment. Hence, we present a case successfully treated with hyaluronic acid filler injection on a patient under imatinib mesylate treatment. We carefully propose that hyaluronic acid filler can be an effective means of rejuvenation and cosmetic enhancement for those under imatinib mesylate treatment.
Assuntos
Preenchedores Dérmicos/administração & dosagem , Ácido Hialurônico/administração & dosagem , Mesilato de Imatinib/uso terapêutico , Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico , Nariz , Adulto , Estética , Feminino , HumanosRESUMO
Chronic inflammation is an underlying risk factor of colon cancer, and NF-κB plays a critical role in the development of inflammation-associated colon cancer in an AOM/DSS mouse model. The aim of this study was to determine whether the standardized ethanol extract obtained from the aerial parts of Artemisia princeps Pampanini cv. Sajabal (EAPP) is effective at preventing inflammation-associated colon cancer, and if so, to identify the signaling pathways involved. In the present study, protective efficacy of EAPP on tumor formation and the infiltrations of monocytes and macrophages in colons of an AOM/DSS mouse model were evaluated. It was found that colitis and tumor burdens showed statistically meaningful improvements after EAPP administration. Furthermore, these improvements were accompanied by a reduction in NF-κB activity and in the levels of NF-κB-dependent pro-survival proteins, that is, survivin, cFLIP, XIAP, and Bcl-2. In vitro, EAPP significantly reduced NF-κB activation and the levels of IL-1ß and IL-8 mRNA and pro-survival proteins in HT-29 and HCT-116 colon cancer cells. Furthermore, EAPP caused caspase-dependent apoptosis. Based on these results, the authors suggest EAPP suppresses inflammatory responses and induces apoptosis partly via NF-κB inactivation, and that EAPP could be useful for the prevention of colitis-associated tumorigenesis.
Assuntos
Anticarcinógenos/farmacologia , Artemisia/química , Colite/complicações , Neoplasias do Colo/prevenção & controle , NF-kappa B/metabolismo , Extratos Vegetais/farmacologia , Animais , Apoptose/efeitos dos fármacos , Carcinogênese/efeitos dos fármacos , Neoplasias do Colo/etiologia , Células HCT116 , Células HT29 , Humanos , Interleucina-1beta/genética , Interleucina-1beta/metabolismo , Interleucina-8/genética , Interleucina-8/metabolismo , Macrófagos/efeitos dos fármacos , Masculino , Camundongos , Camundongos Endogâmicos ICR , Monócitos/efeitos dos fármacos , NF-kappa B/antagonistas & inibidores , Componentes Aéreos da Planta/química , RNA Mensageiro/genética , RNA Mensageiro/metabolismoRESUMO
ETHNOPHARMACOLOGICAL RELEVANCE: Rubus coreanus Miquel (Rosaceae), the Korean black raspberry, has traditionally been used to treat inflammatory diseases including diarrhea, asthma, stomach ailment, and cancer. Although previous studies showed that the 19α-hydroxyursane-type triterpenoids isolated from Rubus coreanus exerted anti-inflammatory activities, their effects on ulcerative colitis and mode of action have not been explored. This study was designed to assess the anti-inflammatory effects and the molecular mechanisms involving19α-hydroxyursane-type triterpenoid-rich fraction from Rubus coreanus (TFRC) on a mice model of colitis and lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. MATERIALS AND METHODS: Experimental colitis was induced by DSS for 7 days in ICR mice. Disease activity indices (DAI) took into account body weight, stool consistency, and gross bleeding. Histological changes and macrophage accumulation were observed by immunohistochemical analysis. Pro-inflammatory markers were determined using immunoassays, RT-PCR, and real time PCR. Signaling pathway involving nuclear factor-κB (NF-κB) and mitogen-activated protein kinases (MAPKs) activation was determined by luciferase assay and Western blotting. RESULTS: In DSS-induced colitis mice, TFRC improved DAIs and pathological characteristics including colon shortening and colonic epithelium injury. TFRC suppressed tissue levels of pro-inflammatory cytokines and reduced macrophage infiltration into colonic tissues. In LPS-induced RAW 264.7 macrophages, TFRC inhibited the production of NO, PGE2, and pro-inflammatory cytokines by down-regulating the activation of NF-κB and p38 MAPK signaling. CONCLUSION: The study demonstrates that TFRC has potent anti-inflammatory effects on DSS-induced colonic injury and LPS-induced macrophage activation, and supports its possible therapeutic and preventive roles in colitis.
Assuntos
Colite/prevenção & controle , Sulfato de Dextrana/toxicidade , Lipopolissacarídeos/toxicidade , Macrófagos/efeitos dos fármacos , Extratos Vegetais/farmacologia , Rubus/química , Triterpenos/análise , Animais , Sequência de Bases , Linhagem Celular , Colite/induzido quimicamente , Citocinas/biossíntese , Citocinas/genética , Primers do DNA , Mediadores da Inflamação/metabolismo , Macrófagos/metabolismo , Camundongos , Extratos Vegetais/química , Reação em Cadeia da PolimeraseAssuntos
Anfotericina B/administração & dosagem , Encefalopatias , Ácido Desoxicólico/administração & dosagem , Diabetes Mellitus Tipo 2/complicações , Oftalmopatias , Falência Renal Crônica/complicações , Mucormicose , Antifúngicos/administração & dosagem , Biópsia , Encefalopatias/diagnóstico , Encefalopatias/etiologia , Encefalopatias/fisiopatologia , Combinação de Medicamentos , Olho/patologia , Oftalmopatias/diagnóstico , Oftalmopatias/etiologia , Oftalmopatias/fisiopatologia , Evolução Fatal , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Pessoa de Meia-Idade , Mucormicose/diagnóstico , Mucormicose/etiologia , Mucormicose/fisiopatologia , Insuficiência de Múltiplos Órgãos , Seios Paranasais/patologia , Lobo Temporal/patologiaRESUMO
The etiologic agents for pityriasis lichenoides et varioliformis acuta (PLEVA) are largely unknown, although it has been suggested that foreign antigens such as infectious agents are the pathogenic mechanism. We present a case suggesting a possible relationship between varicella-zoster virus and PLEVA.
Assuntos
Herpesvirus Humano 3/isolamento & purificação , Pitiríase Liquenoide/diagnóstico , Pitiríase Liquenoide/virologia , Corticosteroides/uso terapêutico , Antibacterianos/uso terapêutico , Biópsia , Criança , Diagnóstico Diferencial , Feminino , Humanos , Pitiríase Liquenoide/tratamento farmacológico , Roxitromicina/uso terapêuticoRESUMO
ETHNOPHARMACOLOGICAL RELEVANCE: Korean red ginseng (KRG) has been shown to possess various biological activities including anti-inflammatory properties. AIM OF THE STUDY: We aimed to investigate the effects and mechanism of KRG on the prevention of atopic dermatitis (AD) using a mouse model. MATERIALS AND METHODS: The effect of KRG in trinitrochlorobenzene (TNCB)-treated NC/Nga mice was assessed by measuring ear thickness, transepidermal water loss (TEWL), total serum IgE, histologic changes of lesional skin, mRNA and protein expression of thymic stromal lymphopoietin (TSLP) and tumor necrosis factor (TNF)-α, immunohistochemistry for tissue interleukin (IL)-4, IL-17, and interferon (IFN)-γ. RESULTS: KRG significantly reduced ear thickness. Oral administration of KRG significantly prevented the increase in TEWL induced by TNCB. The serum IgE level was significantly lower in the KRG group. Histologically, lymphocyte infiltration was markedly decreased by KRG. CD1a positive (CD1a+) cells were diminished by KRG. Immunohistochemically, KRG significantly suppressed the protein expression of TSLP and TNF-α. The mRNA expression of TSLP in the lesions was significantly reduced by KRG. These results demonstrate that oral administration of KRG may inhibit the development of AD-like skin lesions in NC/Nga mice by modifying TSLP, DCs, and at least in part, the Th2 response. CONCLUSION: KRG may be a potential therapeutic modality for the prevention of AD.
Assuntos
Dermatite Atópica/tratamento farmacológico , Modelos Animais de Doenças , Extratos Vegetais/uso terapêutico , Animais , Citocinas/biossíntese , Dermatite Atópica/sangue , Dermatite Atópica/induzido quimicamente , Feminino , Imunoglobulina E/metabolismo , Interferon gama/metabolismo , Interleucina-17/metabolismo , Interleucina-4/metabolismo , Linfócitos/efeitos dos fármacos , Camundongos , Camundongos Endogâmicos , Panax/química , Fitoterapia , Cloreto de Picrila , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Raízes de Plantas/química , Índice de Gravidade de Doença , Pele/efeitos dos fármacos , Pele/patologia , Água/química , Água/metabolismo , Linfopoietina do Estroma do TimoAssuntos
Antibióticos Antineoplásicos/efeitos adversos , Carcinoma Hepatocelular/terapia , Quimioembolização Terapêutica/efeitos adversos , Toxidermias/etiologia , Neoplasias Hepáticas/terapia , Adulto , Idoso , Antibióticos Antineoplásicos/administração & dosagem , Doxorrubicina/administração & dosagem , Doxorrubicina/efeitos adversos , Feminino , Humanos , MasculinoRESUMO
Chondroid syringoma is an uncommon benign neoplasm in the skin. It is composed of epithelial and myoepithelial cells embedded in a matrix with varying amounts of mucoid and cartilaginous material. Chondroid syringoma is classified into 2 types, the apocine type and the eccrine type. Several cases of the eccrine type chondroid syringoma with ossification and calcification have been reported, but the apocrine type chondroid syringoma with calcification has not been reported. In this report, we describe a case of apocrine type chondroid syringoma with calcification.
Assuntos
Adenoma Pleomorfo/patologia , Glândulas Apócrinas/patologia , Calcinose/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Feminino , Humanos , Pessoa de Meia-IdadeAssuntos
Anticorpos Monoclonais Humanizados/efeitos adversos , Antineoplásicos/efeitos adversos , Carotenoides/sangue , Cor , Pele/efeitos dos fármacos , Adulto , Anticorpos Monoclonais Humanizados/uso terapêutico , Antineoplásicos/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Quimioterapia Adjuvante , Feminino , Pé , Mãos , Humanos , Pessoa de Meia-Idade , TrastuzumabRESUMO
Pigmentary demarcation lines are abrupt transition lines between the areas of deeper pigmentation and the areas of lighter, normal pigmentation. Type B pigmentary demarcation lines involve the posterior medial portion of the lower extremities and are more commonly associated with pregnancy. We present a case of pigmentary demarcation lines of pregnancy with erythematous changes, involving both the anterior and posterior aspects of the lower extremities.
RESUMO
Recently, we reported the anti-inflammatory effects of arvelexin isolated from Brassica rapa in macrophages. In the present study, the effects of arvelexin were investigated in a dextran sulfate sodium (DSS)-induced colitis mouse model and in a cellular model. In the DSS-induced colitis model, arvelexin significantly reduced the severity of colitis, as assessed by disease activity, colonic damage, neutrophil infiltration, and levels of colonic iNOS. Moreover, arvelexin inhibited the expressions of IL-8, IP-10, ICAM-1, and VCAM-1 in HT-29 colonic epithelial cells. Arvelexin also inhibited the TNF-α-induced adhesion of U937 monocytic cells to HT-29 cells. Furthermore, arvelexin reduced p65 NF-κB subunit translocation to the nucleus and IκBα degradation in the colonic tissues and in TNF-α-induced HT-29 cells. These results demonstrate that the ameliorative effects of arvelexin on colonic injury are mainly related to its ability to inhibit the inflammatory responses via NF-κB inactivation, and support its possible therapeutic role in colitis.