[The transplacental transport and effect of morphine administered in the prenatal period on its level in adult rats]. / Transplatsentarnyi perenos i vliianie morfina, vvedennogo v prenatal'nom periode, na ego soderzhanie u vzroslykh krys.

The morphine concentration in the placenta, plasma of pregnant rats and their fetuses and in the plasma of prenatally morphinized rats was determined with HPLC method. It was found that 10 min after the intraperitoneal morphine administration at a dose of 20 mg/kg the morphine concentration in the fetus blood plasma is 3 times as large and in the placenta is 2 times as large as in the blood plasma of pregnant rats. The morphine level in prenatally morphinized rats was reliably higher than that in the control animals.

[The effect of fenazepam and phenobarbital administered prenatally and in the early postnatal period on the behavioral reactions of rat progeny]. / Vliianie fenazepama i fenobarbitala, vvodimykh v prenatal'nom i rannem postnatal'nom periodakh, na povedencheskie reaktsii potomstva krys.

Phenazepam, 10 mg/kg/day, or phenobarbital, 30 mg/kg/day, administered to female rats during the entire pregnancy and 5 days after delivery during lactation induced behavioral changes in their offsprings at early (1.5-2 months) and later (4 months) ages. Phenobarbital produced a more marked effect on the central nervous system than phenazepam by causing impairments of extrapolatory reflexes and behavioral stereotype in a conflict situation or open field.

[The effect of fenazepam and phenobarbital on the course of pregnancy in rats and on the early postnatal development of their progeny]. / Vliianie fenazepama i fenobarbitala na techenie beremennosti krys i rannee postnatal'noe razvitie ikh potomstva.

Examining the effects of phenazepam and phenobarbital on the course of pregnancy and the development of offsprings has revealed that phenobarbital that has an embryotoxic effect reduced the number of rat offsprings and diminished their weight, but failed to affect the behavioral responses of newborn rats. On the contrary, phenazepam had no embryotoxic effect, but on entering the newborn rats' organism with milk it inhibited some behavioral reactions in the early postnatal period.

[Effect of piracetam on the postnatal development of rats]. / Vliianie piratsetama na postnatal'noe razvitie krys.

Administration of piracetam (2 g/kg) to rats during the whole pregnancy caused a decrease of motor activity in young rats at an early age and an increase of the activity of adult male rats. The antenatal use of piracetam improved learning abilities and tolerance of stress situations in the offspring.

[Effect of teturam on the development of the offspring of alcoholized animals]. / Vliianie teturama na razvitie potomstva alkogolizirovannykh zhivotnykh.

During experiments on rats it was found that in alcoholized animals teturam on the whole did not potentiate and in some cases even attenuated the toxic effect of alcohol on the offspring development. The data confirm the idea about necessity of studying toxicity of drugs under the conditions corresponding to their clinical use.