Rosiglitazone toxicity: accidental overdose leading to macular edema.

BACKGROUND/PURPOSE: To highlight the clinical effects of rosiglitazone overdose. METHODS: Case report, observational. RESULTS: A 60-year-old Chinese man accidentally ingested 20 mg rosiglitazone. His usual dose was 2 mg once in the morning. Complications of drug overdose were monitored. He consequently developed right mild macular edema. This resolved spontaneously without laser treatment. No systemic toxicity, hypoglycemia, or peripheral edema was observed. CONCLUSION: Rosiglitazone overdose causes acute macular edema that resolves spontaneously.