Patterns of interventions for central venous catheter-associated deep vein thrombosis and outcomes in cancer patients.

PURPOSE: This letter evaluated the impact of different management strategies, specifically the presence or absence of therapeutic anticoagulation, on clinical outcomes for central venous catheter (CVC)-associated deep vein thrombosis (DVT) in cancer patients. METHODS: One-hundred ninety-eight adult cancer patients with a confirmed CVC-associated DVT diagnosis from February 2013 and February 2021 were included. RESULTS: Incidence of symptomatic recurrent venous thromboembolism (VTE) was similar between patients who received therapeutic anticoagulation and those who did not (14% vs 16%, p = 0.807). In addition, therapeutic anticoagulation did not significantly alter the incidence of grade 3 and above bleeding events despite most patients having hematologic malignancies (9% vs 8%, p = 0.826). CONCLUSION AND RELEVANCE: Therapeutic anticoagulation was not associated with a reduction in the incidence of recurrent VTE or increase the incidence of bleeding in adult cancer patients following a CVC-associated DVT diagnosis.

Perceived quality of life of adults with developmental and other significant disabilities.

PURPOSE: The purpose of this qualitative study was to describe the perceived quality of life (PQOL) of adults with significant disabilities who were living in community settings. METHODS: Six male and six female volunteers (mean age 48 years, standard deviation 14 years), half with developmental and half with acquired disabilities, were interviewed about their quality of life. The interviews were audio-taped and transcribed verbatim. Text units were identified in the narrative data and were coded, sorted, and entered in an Index Tree. Data analysis utilized the Constant Comparison Technique with underlying themes emerging in 11 areas. RESULTS: The highest PQOL was noted in Health and Housing; the lowest in Transportation/Physical Accessibility and Employment. Deficits in Transportation/Physical Accessibility compromised PQOL in other areas. In regards to employment, seasonal, part-time and occasional work were common, and assistive technology and computers were rarely used to enhance employment capabilities. PQOL depended on the availability of appropriate supports and services, and tended to differ between those with developmental and those with acquired disabilities. CONCLUSION: Policy makers and advocacy groups could best improve the PQOL for those with severe disabilities by facilitating transportation and employment services.