Biofabrication of 3D adipose tissue via assembly of composite stem cell spheroids containing adipo-inductive dual-signal delivery nanofibers.

Reconstruction of large 3D tissues based on assembly of micro-sized multi-cellular spheroids has gained attention in tissue engineering. However, formation of 3D adipose tissue from spheroids has been challenging due to the limited adhesion capability and restricted cell mobility of adipocytes in culture media. In this study, we addressed this problem by developing adipo-inductive nanofibers enabling dual delivery of indomethacin and insulin. These nanofibers were introduced into composite spheroids comprising human adipose-derived stem cells (hADSCs). This approach led to a significant enhancement in the formation of uniform lipid droplets, as evidenced by the significantly increased Oil red O-stained area in spheroids incorporating indomethacin and insulin dual delivery nanofibers (56.9 ± 4.6%) compared to the control (15.6 ± 3.5%) with significantly greater gene expression associated with adipogenesis (C/EBPA, PPARG, FABP4, and adiponectin) of hADSCs. Furthermore, we investigated the influence of culture media on the migration and merging of spheroids and observed significant decrease in migration and merging of spheroids in adipogenic differentiation media. Conversely, the presence of adipo-inductive nanofibers promoted spheroid fusion, allowing the formation of macroscopic 3D adipose tissue in the absence of adipogenic supplements while facilitating homogeneous adipogenesis of hADSCs. The approach described here holds promise for the generation of 3D adipose tissue constructs by scaffold-free assembly of stem cell spheroids with potential applications in clinical and organ models.

Spatial mapping of land susceptibility to dust emissions using optimization of attentive Interpretable Tabular Learning (TabNet) model.

Dust pollution poses significant risks to human health, air quality, and food safety, necessitating the identification of dust occurrence and the development of dust susceptibility maps (DSMs) to mitigate its effects. This research aims to detect dust occurrence using satellite images and prepare a DSM for Bushehr province, Iran, by enhancing the attentive interpretable tabular learning (TabNet) model through three swarm-based metaheuristic algorithms: particle swarm optimization (PSO), grey wolf optimizer (GWO), and hunger games search (HGS). A spatial database incorporating dust occurrence areas was created using Moderate Resolution Imaging Spectroradiometer (MODIS) images from 2002 to 2022, including 15 influential criteria related to climate, soil, topography, and land cover. Four models were employed for modeling and DSM generation: TabNet, TabNet-PSO, TabNet-GWO, and TabNet-HGS. Evaluation of the modeling results using performance metrics indicated that the TabNet-HGS model outperformed the other models in both training (mean absolute error (MAE) = 0.055, root-mean-square error (RMSE) = 0.1, coefficient of determination (R2) = 0.959), and testing (MAE = 0.063, RMSE = 0.114, R2 = 0.947) data. Following TabNet-HGS, the TabNet-PSO, TabNet-GWO, and TabNet models demonstrated progressively lower accuracy. The validation of the DSM was performed by assessing receiver operating characteristic (ROC) curves, revealing that the TabNet-HGS, TabNet-PSO, TabNet-GWO, and TabNet models exhibited the highest modeling accuracy, with corresponding area under the curve (AUC) values of 0.994, 0.986, 0.98, and 0.832, respectively. These results highlight the enhanced accuracy of dust susceptibility modeling achieved by integrating swarm-based metaheuristic algorithms with the TabNet model. The dust susceptibility map provides valuable insights into the sources, pathways, and impacts of dust particles on the environment and human health in the study area.

Temporal dynamics of urban gas pipeline risks.

Urban gas pipelines pose significant risks to public safety and infrastructure integrity, necessitating thorough risk assessment methodologies to mitigate potential hazards. This study investigates the dynamics of population distribution, demographic characteristics, and building structures to assess the risk associated with gas pipelines. Using geospatial analysis techniques, we analyze population distribution patterns during both day and night periods. Additionally, we conduct an in-depth vulnerability assessment considering multiple criteria maps, highlighting areas of heightened vulnerability in proximity to gas pipelines and older buildings. This study incorporated the concept of individual risk and the intrinsic parameters of gas pipelines to develop a hazard map. Hazard analysis identifies areas with elevated risks, particularly around main pipeline intersections and high-pressure zones. Integrating hazard and vulnerability assessments, we generate risk maps for both day and night periods, providing valuable insights into spatial risk distribution dynamics. The findings underscore the importance of considering temporal variations in risk assessment and integrating demographic and structural factors into hazard analysis for informed decision-making in pipeline management and safety measures.

Integrated Augmented and Virtual Reality Technologies for Realistic Fire Drill Training.

In this article, we propose a novel fire drill training system designed specifically to integrate augmented reality (AR) and virtual reality (VR) technologies into a single head-mounted display device to provide realistic as well as safe and diverse experiences. Applying hybrid AR/VR technologies in fire drill training may be beneficial because they can overcome limitations such as space-time constraints, risk factors, training costs, and difficulties in real environments. The proposed system can improve training effectiveness by transforming arbitrary real spaces into real-time, realistic virtual fire situations, and by interacting with tangible training props. Moreover, the system can create intelligent and realistic fire effects in AR by estimating not only the object type but also its physical properties. Our user studies demonstrated the potential of integrated AR/VR for improving training and education.

A new approach based on biology-inspired metaheuristic algorithms in combination with random forest to enhance the flood susceptibility mapping.

Flash floods are one of the worst natural disasters, causing massive economic losses and many deaths. Creating a flood susceptibility map (FSM) that pinpoints the areas most at risk of flooding is a crucial non-structural solution for managing floods. This study aimed to assess the efficacy of combinations of the random forest (RF) model with three biology-inspired metaheuristic algorithms, namely invasive weed optimization (IWO), slime mould algorithm (SMA), and satin bowerbird optimization (SBO), for flood susceptibility mapping in Estahban town, Iran. Initially, synthetic-aperture radar (SAR) (Sentinel-1) and optical (Landsat-8) satellite images were integrated to monitor the flooded areas during the July 2022 monsoon in the study area. A dataset of 509 flood occurrence points was created to identify flood-prone areas using remote sensing techniques, considering the monitored flood areas. The dataset also included twelve flood-related criteria: topography, land cover, and climate. The holdout method was employed for modeling, with a ratio of 70:30 used for the train/test split. Data pre-processing techniques were conducted to improve model performance, including determining criteria importance and addressing multicollinearity issues using certainty factor (CF), multicollinearity, and information gain ratio (IGR) methods. Then FSM was prepared using RF, RF-IWO, RF-SBO, and RF-SMA models. The findings of this research revealed that the RF-IWO model was the best predictive model of flood susceptibility modeling, with root-mean-square-error (RMSE) (0.211 and 0.0.27), mean-absolute-error (MAE) (0.103 and 0.15), and coefficient-of-determination (R2) (0.821 and 0.707) in the training and testing phases, respectively. Receiver operating characteristic (ROC) curve analysis of FSM revealed that the most accurate models were the RF-IWO (area under the curve (AUC) = 0.983), RF-SBO (AUC = 0.979), RF-SMA (AUC = 0.963), and RF (AUC = 0.959), respectively. Integrating biology-inspired computing algorithms with machine learning algorithms presents a novel approach to enhancing the accuracy of FSMs.

Dust detection and susceptibility mapping by aiding satellite imagery time series and integration of ensemble machine learning with evolutionary algorithms.

To mitigate the impact of dust on human health and the environment, it is crucial to create a model and map that identifies the areas susceptible to dust. The present study focused on identifying dust occurrences in the Bushehr province of Iran between 2002 and 2022 using moderate-resolution imaging spectroradiometer (MODIS) imagery. Subsequently, an ensemble machine learning model was improved to prepare a dust susceptibility map (DSM). The study employed differential evolution (DE), genetic algorithm (GA), and flower pollination algorithm (FPA) - three evolutionary algorithms - to enhance the random forest (RF) ensemble model. A spatial database was created for modeling, including 519 dust occurrence points (extracted from MODIS imagery) and 15 factors affecting dust (Slope, bulk density, aspect, clay, altitude, sand, rainfall, lithology, soil order, distance to river, soil texture, normalized difference vegetation index (NDVI), soil water content, land cover, and wind speed). By utilizing the differential evolution (DE) algorithm, we determined the significance of these factors in impacting dust occurrences. The results indicated that altitude, wind speed, and land cover were the most influential factors, while the distance to the river, bulk density, and soil texture had less impact on dust occurrence. Data were preprocessed using multicollinearity analysis and the frequency ratio (FR) approach. For this research, three RF-based meta-heuristic optimization algorithms, namely RF-FPA, RF-GA, and RF-DE, were created for DSM. The effectiveness prediction of the constructed models by indexes of root-mean-square-error (RMSE), the area under the receiver operating characteristic (AUC-ROC), and coefficient of determination (R2) from best to worst were RF-DE (RMSE = 0.131, AUC-ROC = 0.988, and R2 = 0.93), RF-GA (RMSE = 0.141, AUC-ROC = 0.986, and R2 = 0.919), RF-FPA (RMSE = 0.157, AUC-ROC = 0.981, and R2 = 0.9), and RF (RMSE = 0.173, AUC-ROC = 0.964, and R2 = 0.878). The results showed that combining evolutionary algorithms with an RF model improves the accuracy of dust susceptibility modeling.

Application of genetic algorithm in optimization parallel ensemble-based machine learning algorithms to flood susceptibility mapping using radar satellite imagery.

Floods are the natural disaster that occurs most frequently due to the weather and causes the most widespread destruction. The purpose of the proposed research is to analyze flood susceptibility mapping (FSM) in the Sulaymaniyah province of Iraq. This study employed a genetic algorithm (GA) to fine-tune parallel ensemble-based machine learning algorithms (random forest (RF) and bootstrap aggregation (Bagging)). Four machine learning algorithms (RF, Bagging, RF-GA, and Bagging-GA) were used to build FSM in the study area. To provide inputs into parallel ensemble-based machine learning algorithms, we gathered and processed data from meteorological (Rainfall), satellite image (flood inventory, normalized difference vegetation index (NDVI), aspect, land cover, altitude, stream power index (SPI), plan curvature, topographic wetness index (TWI), slope) and geographic sources (geology). For this research, Sentinel-1 synthetic aperture radar (SAR) satellite images were utilized to locate flooded areas and create an inventory map of floods. To train and validate the model, we employed 70 % and 30 % of 160 selected flood locations, respectively. Multicollinearity, frequency ratio (FR), and Geodetector methods were used for data preprocessing. Four metrics were utilized to assess the FSM performance: the root mean square error (RMSE), the area under the receiver-operator characteristic curve (AUC-ROC), the Taylor diagram, and the seed cell area index (SCAI). The results exhibited that all the suggested models have high accuracy of prediction, but the performance of Bagging-GA (RMSE (Train = 0.1793, Test = 0.4543)) was slightly better than RF-GA (RMSE (Train = 0.1803, Test = 0.4563)), Bagging (RMSE (Train = 0.2191, Test = 0.4566)), and RF (RMSE (Train = 0.2529, Test = 0.4724)). According to the ROC index, the Bagging-GA model (AUC = 0.935) was the most accurate in flood susceptibility modeling, followed by the RF-GA (AUC = 0.904), the Bagging (AUC = 0.872), and the RF (AUC = 0.847) models. The study's identification of high-risk flood zones and the most significant factors contributing to flooding make it a helpful resource for flood management.

Composite Multicellular Spheroids Containing Fibers with Pores and Epigallocatechin Gallate (EGCG) Coating on the Surface for Enhanced Proliferation of Stem Cells.

Multicellular spheroids are formed by strong cell-cell and cell-extracellular matrix interactions and are widely utilized in tissue engineering for therapeutic treatments or ex vivo tissue modeling. However, diffusion of oxygen into the spheroid gradually decreases, forming a necrotic core. In this study, polycaprolactone (PCL) fibers with pores and epigallocatechin gallate (EGCG) coating on their surface to provide a structural framework within the spheroids and investigated their ability to mitigate diffusional limitation and control over the proliferation of human adipose-derived stem cells (hADSCs) is engineered. The DNA content of composite spheroids prepared from fibers and hADSCs decreased in unadjusted cells (1224 ± 134 ng), in those with fibers with a smooth surface (SF) (1447 ± 331 ng), and in those EGCG-coated with SF (E-SF) (1437 ± 289 ng). Cells with fibers with pores on the surface (PF) (2020 ± 32 ng) and those with EGCG-coated PF (E-PF) (1911 ± 80 ng) increased after 7 days of culture, with a significantly greater number of proliferating cells (29 ± 8% and 30 ± 8%, respectively). These results indicate that physical modification through the formation of pores on the fiber surface alleviates diffusion limitation of composite spheroids, playing a dominant role over chemical modification.

Coronavirus disease vulnerability map using a geographic information system (GIS) from 16 April to 16 May 2020.

In recent months, the world has been affected by the infectious coronavirus disease and Iran is one of the most affected countries. The Iranian government's health facilities for an urgent investigation of all provinces do not exist simultaneously. There is no management tool to identify the vulnerabilities of Iranian provinces in prioritizing health services. The aim of this study was to prepare a coronavirus vulnerability map of Iranian provinces using geographic information system (GIS) to monitor the disease. For this purpose, four criteria affecting coronavirus, including population density, percentage of older people, temperature, and humidity, were prepared in the GIS. A multiscale geographically weighted regression (MGWR) model was used to determine the vulnerability of coronavirus in Iran. An adaptive neuro-fuzzy inference system (ANFIS) model was used to predict vulnerability in the next two months. Results indicated that, population density and older people have a more significant impact on coronavirus in Iran. Based on MGWR models, Tehran, Mazandaran, Gilan, and Alborz provinces were more vulnerable to coronavirus in February and March. The ANFIS model findings showed that West Azerbaijan, Zanjan, Fars, Yazd, Semnan, Sistan and Baluchistan, and Tehran provinces were more vulnerable in April and May.

COVID-19 Risk Mapping with Considering Socio-Economic Criteria Using Machine Learning Algorithms.

The reduction of population concentration in some urban land uses is one way to prevent and reduce the spread of COVID-19 disease. Therefore, the objective of this study is to prepare the risk mapping of COVID-19 in Tehran, Iran, using machine learning algorithms according to socio-economic criteria of land use. Initially, a spatial database was created using 2282 locations of patients with COVID-19 from 2 February 2020 to 21 March 2020 and eight socio-economic land uses affecting the disease-public transport stations, supermarkets, banks, automated teller machines (ATMs), bakeries, pharmacies, fuel stations, and hospitals. The modeling was performed using three machine learning algorithms that included random forest (RF), adaptive neuro-fuzzy inference system (ANFIS), and logistic regression (LR). Feature selection was performed using the OneR method, and the correlation between land uses was obtained using the Pearson coefficient. We deployed 70% and 30% of COVID-19 patient locations for modeling and validation, respectively. The results of the receiver operating characteristic (ROC) curve and the area under the curve (AUC) showed that the RF algorithm, which had a value of 0.803, had the highest modeling accuracy, which was followed by the ANFIS algorithm with a value of 0.758 and the LR algorithm with a value of 0.747. The results showed that the central and the eastern regions of Tehran are more at risk. Public transportation stations and pharmacies were the most correlated with the location of COVID-19 patients in Tehran, according to the results of the OneR technique, RF, and LR algorithms. The results of the Pearson correlation showed that pharmacies and banks are the most incompatible in distribution, and the density of these land uses in Tehran has caused the prevalence of COVID-19.

Effects of air pollution in Spatio-temporal modeling of asthma-prone areas using a machine learning model.

Industrialization and increasing urbanization have led to increased air pollution, which has a devastating effect on public health and asthma. This study aimed to model the spatial-temporal of asthma in Tehran, Iran using a machine learning model. Initially, a spatial database was created consisting of 872 locations of asthma children and six air pollution parameters, including carbon monoxide (CO), particulate matter (PM10 and PM2.5), nitrogen dioxide (NO2), sulfur dioxide (SO2), and ozone (O3) in four-seasons (spring, summer, autumn, and winter). Spatial-temporal modeling and mapping of asthma-prone areas were performed using a random forest (RF) model. For Spatio-temporal modeling and assessment, 70% and 30% of the dataset were used, respectively. The Spearman correlation and RF model findings showed that during different seasons, the PM2.5 parameter had the most important effect on asthma occurrence in Tehran. The assessment of the Spatio-temporal modeling of asthma using the receiver operating characteristic (ROC)-area under the curve (AUC) showed an accuracy of 0.823, 0.821, 0.83, and 0.827, respectively for spring, summer, autumn, and winter. According to the results, asthma occurs more often in autumn than in other seasons.

Asthma-prone areas modeling using a machine learning model.

Nowadays, owing to population growth, increasing environmental pollution, and lifestyle changes, the number of asthmatics has significantly increased. Therefore, the purpose of our study was to determine the asthma-prone areas in Tehran, Iran considering environmental, spatial factors. Initially, we built a spatial database using 872 locations of children with asthma and 13 environmental factors affecting the disease-distance to parks and streets, rainfall, temperature, humidity, pressure, wind speed, particulate matter (PM 10 and PM 2.5), ozone (O3), sulfur dioxide (SO2), carbon monoxide (CO), and nitrogen dioxide (NO2). Subsequently, utilizing this spatial database, a random forest (RF) machine learning model, and a geographic information system, we prepared a map of asthma-prone areas. For modeling and validation, we deployed 70% and 30%, respectively, of the locations of children with asthma. The results of spatial autocorrelation and RF model showed that the criteria of distance to parks and streets as well as PM 2.5 and PM 10 had the greatest impact on asthma occurrence in the study area. Spatial autocorrelation analyses indicated that the distribution of asthma cases was not random. According to receiver operating characteristic results, the RF model had good accuracy (the area under the curve was 0.987 and 0.921, respectively, for training and testing data).

Performance Analysis of IoT-Based Health and Environment WSN Deployment.

With the development of Internet of Things (IoT) applications, applying the potential and benefits of IoT technology in the health and environment services is increasing to improve the service quality using sensors and devices. This paper aims to apply GIS-based optimization algorithms for optimizing IoT-based network deployment through the use of wireless sensor networks (WSNs) and smart connected sensors for environmental and health applications. First, the WSN deployment research studies in health and environment applications are reviewed including fire monitoring, precise agriculture, telemonitoring, smart home, and hospital. Second, the WSN deployment process is modeled to optimize two conflict objectives, coverage and lifetime, by applying Minimum Spanning Tree (MST) routing protocol with minimum total network lengths. Third, the performance of the Bees Algorithm (BA) and Particle Swarm Optimization (PSO) algorithms are compared for the evaluation of GIS-based WSN deployment in health and environment applications. The algorithms were compared using convergence rate, constancy repeatability, and modeling complexity criteria. The results showed that the PSO algorithm converged to higher values of objective functions gradually while BA found better fitness values and was faster in the first iterations. The levels of stability and repeatability were high with 0.0150 of standard deviation for PSO and 0.0375 for BA. The PSO also had lower complexity than BA. Therefore, the PSO algorithm obtained better performance for IoT-based sensor network deployment.

Spatial modeling of long-term air temperatures for sustainability: evolutionary fuzzy approach and neuro-fuzzy methods.

This paper investigates the capabilities of the evolutionary fuzzy genetic (FG) approach and compares it with three neuro-fuzzy methods-neuro-fuzzy with grid partitioning (ANFIS-GP), neuro-fuzzy with subtractive clustering (ANFIS-SC), and neuro-fuzzy with fuzzy c-means clustering (ANFIS-FCM)-in terms of modeling long-term air temperatures for sustainability based on geographical information. In this regard, to estimate long-term air temperatures for a 40-year (1970-2011) period, the models were developed using data for the month of the year, latitude, longitude, and altitude obtained from 71 stations in Turkey. The models were evaluated with respect to mean absolute error (MAE), root mean square error (RMSE), Nash-Sutcliffe efficiency (NSE), and the determination coefficient (R2). All data were divided into three parts and every model was tested on each. The FG approach outperformed the other models, enhancing the MAE, RMSE, NSE, and R2 of the ANFIS-GP model, which yielded the highest accuracy among the neuro-fuzzy models by 20%, 30%, and 4%, respectively. A geographical information system was used to obtain temperature maps using estimates of the optimal models, and the results of the model were assessed using it.

A Survey of Marker-Less Tracking and Registration Techniques for Health & Environmental Applications to Augmented Reality and Ubiquitous Geospatial Information Systems.

Most existing augmented reality (AR) applications are suitable for cases in which only a small number of real world entities are involved, such as superimposing a character on a single surface. In this case, we only need to calculate pose of the camera relative to that surface. However, when an AR health or environmental application involves a one-to-one relationship between an entity in the real-world and the corresponding object in the computer model (geo-referenced object), we need to estimate the pose of the camera in reference to a common coordinate system for better geo-referenced object registration in the real-world. New innovations in developing cheap sensors, computer vision techniques, machine learning, and computing power have helped to develop applications with more precise matching between a real world and a virtual content. AR Tracking techniques can be divided into two subcategories: marker-based and marker-less approaches. This paper provides a comprehensive overview of marker-less registration and tracking techniques and reviews their most important categories in the context of ubiquitous Geospatial Information Systems (GIS) and AR focusing to health and environmental applications. Basic ideas, advantages, and disadvantages, as well as challenges, are discussed for each subcategory of tracking and registration techniques. We need precise enough virtual models of the environment for both calibrations of tracking and visualization. Ubiquitous GISs can play an important role in developing AR in terms of providing seamless and precise spatial data for outdoor (e.g., environmental applications) and indoor (e.g., health applications) environments.

Enhancing response coordination through the assessment of response network structural dynamics.

Preparing for intensifying threats of emergencies in unexpected, dangerous, and serious natural or man-made events, and consequent management of the situation, is highly demanding in terms of coordinating the personnel and resources to support human lives and the environment. This necessitates prompt action to manage the uncertainties and risks imposed by such extreme events, which requires collaborative operation among different stakeholders (i.e., the personnel from both the state and local communities). This research aims to find a way to enhance the coordination of multi-organizational response operations. To do so, this manuscript investigates the role of participants in the formed coordination response network and also the emergence and temporal dynamics of the network. By analyzing an inter-personal response coordination operation to an extreme bushfire event, the networks' and participants' structural change is evaluated during the evolution of the operation network over four time durations. The results reveal that the coordination response network becomes more decentralized over time due to the high volume of communication required to exchange information. New emerging communication structures often do not fit the developed plans, which stress the need for coordination by feedback in addition to by plan. In addition, we find that the participant's brokering role in the response operation network identifies a formal and informal coordination role. This is useful for comparison of network structures to examine whether what really happens during response operations complies with the initial policy.

Volumetric Analysis of 3-D-Cultured Colonies in Wet Alginate Spots Using 384-Pillar Plate.

The volumetric analysis of three-dimensional (3-D)-cultured colonies in alginate spots has been proposed to increase drug efficacy. In a previously developed pillar/well chip platform, colonies within spots are usually stained and dried for analysis of cell viability using two-dimensional (2-D) fluorescent images. Since the number of viable cells in colonies is directly related to colony volume, we proposed the 3-D analysis of colonies for high-accuracy cell viability calculation. The spots were immersed in buffer, and the 3-D volume of each colony was calculated from the 2-D stacking fluorescent images of the spot with different focal positions. In the experiments with human gastric carcinoma cells and anticancer drugs, we compared cell viability values calculated using the 2-D area and 3-D volume of colonies in the wet and dried alginate spots, respectively. The IC50 value calculated using the 3-D volume of the colonies (9.5 µM) was less than that calculated in the 2-D area analysis (121.5 µM). We observed that the colony showed a more sensitive drug response regarding volume calculated from the 3-D image reconstructed using several confocal images than regarding colony area calculated in the 2-D analysis.

Pulmonary tumor thrombotic microangiopathy caused by prostate carcinoma.

Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal malignancy-related condition that involves rapidly progressing hypoxia and pulmonary hypertension. We report a case of PTTM caused by prostate carcinoma, which was diagnosed before autopsy in an 81-year-old man. Computed tomography showed diffuse ground-glass opacities, consolidation, and small nodules in the peripheral regions of the lung. Autopsy showed adenocarcinoma cells embolizing small pulmonary arteries with fibrocellular intimal proliferation, which was consistent with PTTM caused by prostate carcinoma.

Evaluation of suspicious nipple discharge by magnetic resonance mammography based on breast imaging reporting and data system magnetic resonance imaging descriptors.

PURPOSE: To evaluate the findings of magnetic resonance mammography for suspicious nipple discharge based on breast imaging-reporting and data system magnetic resonance imaging (MRI) descriptors and establish any correlations with the histopathologic diagnoses. METHODS: Forty-seven patients with suspicious nipple discharge underwent MRI using a 1.5-T system. Images were evaluated for a signal of abnormal discharge, related abnormal enhancement according to the breast imaging-reporting and data system MRI descriptors, and the presence of clustered ring enhancement and were compared with the histopathologic diagnoses established in 39 lesions. RESULTS: The most common finding in patients with suspicious nipple discharge was non-masslike enhancement. Seventeen malignant and 22 benign lesions were detected. The most frequent findings in the malignant lesions were "segmental" (59%), "heterogeneous" (57%), and plateau pattern (40%). Clustered ring enhancement was found in 60% of the enhanced malignant lesions (P = 0.002). The combination of segmental distribution and clustered ring enhancement showed a significant association with malignant lesions (P = 0.004). CONCLUSIONS: Magnetic resonance imaging provides clinically useful information in patients with suspicious nipple discharge.

Strategies for sustainable development of industrial park in Ulsan, South Korea--from spontaneous evolution to systematic expansion of industrial symbiosis.

The Korea National Cleaner Production Center (KNCPC) affiliated to the Korea Institute of Industrial Technology (KITECH) has started a 15 year, 3-phase EIP master plan with the support of Ministry of Commerce, Industry, and Energy (MOCIE). A total of 6 industrial parks, including industrial parks in Ulsan city, known as the industrial capital of South Korea, are planning projects to find the feasibility of shifting existing industrial parks to eco-industrial parks. The basic survey shows that Ulsan industrial complex has been continuously evolving from conventional industrial complexes to eco-industrial parks by spontaneous industrial symbiosis. This paper describes the Korean national policies and the developmental activities of this vision to drive the global trend of innovation for converting the existing industrial parks to eco-industrial parks through inter-industry waste, energy, and material exchange in Ulsan Industrial complexes. In addition, the primary and supportive components of the Ulsan EIP pilot project, which will be implemented for 5 years is elaborated with its schedules and economic benefits.