RESUMO
This paper sums up recent intervention epidemiological studies of primary atherogeneous hypercholesterolemias. The authors include in this category familial hypercholesterolemia, familial combined hyperlipidemia, and polygenous hypercholesterolemia. Individual disorders are thoroughly analyzed in view of their early diagnostics, differential diagnostics and clinical state. The paper also deals with relatively harmless hypercholesterolemias and their clinical and biochemical criteria.
Assuntos
Arteriosclerose/etiologia , Hipercolesterolemia/complicações , Hiperlipidemia Familiar Combinada/complicações , Hiperlipoproteinemia Tipo II/complicações , Adulto , Idoso , Pré-Escolar , Diagnóstico Diferencial , Feminino , Humanos , Hipercolesterolemia/diagnóstico , Hiperlipidemia Familiar Combinada/diagnóstico , Hiperlipoproteinemia Tipo II/diagnóstico , Masculino , Fatores de RiscoRESUMO
The authors classify hypertriacylglycerolemias according to their relationship with atherosclerosis as disorders with and without chylomicronemia, atherogenous disorders with an increased level of apolipoprotein B in the VLDL fraction, and relatively harmless (benign) cases. They single out the remarkable heterogeneity of hypertriacylglycerolemias and their epidemiological aspects. The analysis of the various disorders comes complete with their pathobiochemistry and the clinic-biochemical criteria of their classification. The paper also draws attention to a number of possible clinical complications accompanying hypertriacylglycerolemias and their frequency among the population.
Assuntos
Arteriosclerose/etiologia , Hiperlipoproteinemias/classificação , Hiperlipoproteinemias/complicações , Hipertrigliceridemia/classificação , Hipertrigliceridemia/complicações , Quilomícrons/sangue , Feminino , Humanos , Masculino , Fatores de RiscoRESUMO
The article defines apolipoprotein diseases as the structural defects of apolipoproteins or disorders in their synthesis or secretion. The survey covers a range of atherogenous defects, providing a detailed description of their clinical-biochemical and genetic aspects as well as diagnostic and differential diagnostic criteria. Attention is paid also to the significance of analytical isoelectric focusing.
Assuntos
Apolipoproteínas/química , Arteriosclerose/etiologia , Abetalipoproteinemia/classificação , Abetalipoproteinemia/complicações , Apolipoproteínas/sangue , Apolipoproteínas/genética , Feminino , Humanos , Hipolipoproteinemias/classificação , Hipolipoproteinemias/complicações , MasculinoRESUMO
The last chapter deals with the normalipidemic (latent) dyslipoproteinemias, their pathobiochemistry, clinical aspects and the risk of atherosclerosis. In conclusion, the authors sum up the more recent views on the dysbalance of prostaglandins in relation to the cardiovascular diseases, the functions of the vascular wall and blood paletets in atherogenesis.
Assuntos
Arteriosclerose/etiologia , Erros Inatos do Metabolismo Lipídico/complicações , Arteriosclerose/sangue , Humanos , Lipase/sangue , Erros Inatos do Metabolismo Lipídico/sangue , Lipídeos/sangue , Lipase Lipoproteica/sangue , Lipoproteínas/sangue , Triglicerídeos/sangueRESUMO
This paper sums up new findings in the field of pathogenetic relations between lipid and lipoprotein metabolical disorders on the one hand and the risk of early forms of atherosclerosis on the other hand. Detail classification of disorders proceeds from precise clinical and biochemical criteria, genetic considerations and therapeutical aspects. It provides definitions of hyperlipidemia, hyperlipoproteinemia, normolipidemic (latent) dyslipoproteinemia, secondary hyperlipidemia, apolipoproteinopathia and relatively harmless (benign) hyperlipidemia. The paper provides detail tables and systematic graphs.
