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Objective To explore the effect of simvastatin combined with cyclosporin A treatment on the development of obliterative bronchiolitis in a murine heterotopic tracheal transplantation model .Methods Murine tracheals were heterotopically transplanted from BALB/c donors into C57BL/6 recipients .Transplanted animals received either control chow ,chow containing simvastatin ,chow containing cyclosporine A ,or chow containing simvastatin and cyclosporine A . beginning immediately after transplantation .Epithelial loss and luminal obstruction were analyzed by morphometry .Immunohistochemistry assay was used for quantifying inflammatory cell infiltration and expression of chemokine in tracheal allografts .collagen deposition was studied by picro sirius red staining .Group t test was used to calculate the difference between groups .Results simvastatin combined with cyclosporin A treatment reduced chemokine (MCP-1 , RANTES ) release , inhibited CD4+ and CD8+ T cells and macrophages accumulation in tracheal allografts ,resulting in limited bronchial inflammation and diminished epithelial loss .simvastatin plus cyclosporin A treatment also inhibited proliferation of myofibroblast cells ,reduced M M P-2 release and decreased the amounts of type I and III collagen deposition ,resulting in preserved luminal patency and inhibited development of OB compared with those of controls .Conclusions When simvastatin was used in combination with CsA ,the development of OB was significantly inhibited .
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Objective@#To explore the effect of simvastatin combined with cyclosporin A treatment on the development of obliterative bronchiolitis in a murine heterotopic tracheal transplantation model.@*Methods@#Murine tracheals were heterotopically transplanted from BALB/c donors into C57BL/6 recipients. Transplanted animals received either control chow, chow containing simvastatin, chow containing cyclosporine A, or chow containing simvastatin and cyclosporine A. beginning immediately after transplantation. Epithelial loss and luminal obstruction were analyzed by morphometry. Immunohistochemistry assay was used for quantifying inflammatory cell infiltration and expression of chemokine in tracheal allografts. collagen deposition was studied by picro sirius red staining.Group t test was used to calculate the difference between groups.@*Results@#simvastatin combined with cyclosporin A treatment reduced chemokine(MCP-1, RANTES)release, inhibited CD4+ and CD8+ T cells and macrophages accumulation in tracheal allografts, resulting in limited bronchial inflammation and diminished epithelial loss. simvastatin plus cyclosporin A treatment also inhibited proliferation of myofibroblast cells, reduced MMP-2 release and decreased the amounts of type I and III collagen deposition, resulting in preserved luminal patency and inhibited development of OB compared with those of controls.@*Conclusions@#When simvastatin was used in combination with CsA, the development of OB was significantly inhibited.
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Strategic ability updating relates to establishing some required properties, which can be expressed by strategic abilities, in a multicomponent reactive system. We model such a reactive system as a concurrent game structure (CGS), which is the semantic model of Alternating-time Temporal Logic (ATL). Then, we propose coalitional commitment as a tool for achieving the required strategic ability updating. Intuitively, a coalitional commitment can extend the state space of a CGS by a context function and then delete some transitions by a coalitional normative system (CNS). We propose coordinated ATL (co-ATL) for reasoning about strategic abilities in the structures obtained from a CGS by implementing a CNS. The model-checking problem for co-ATL is proved to be PTIME-complete, just like that of ATL, and is thus tractable. Then, we characterize the limitation of coalitional commitment power by identifying the set of co-ATL formulas whose satisfaction cannot be established and the set of co-ATL formulas whose satisfaction cannot be avoided. Afterward, we show that the effectiveness problem, feasibility problem, and synthesis problem for coalitional commitment are PTIME-complete, NP-complete, and FNP-complete, respectively. Finally, we treat the coalitional commitment synthesis problem as an extended planning problem and present an algorithm based on the planning as model checking paradigm. Our work can be seen as an improvement for both social law research and planning via model checking research.
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<p><b>OBJECTIVE</b>To investigate the laws of eighteen incompatible medicaments of the chest pain prescriptions based on association rules mining.</p><p><b>METHOD</b>The database of chest pain prescription was established and then the chest pain prescriptions composed of eighteen incompatible medicaments were screened. The dynasty, couplet medicines, the property and flavor of drugs and preparation form were analyzed with the frequent item sets and corresponding analysis methods.</p><p><b>RESULT</b>Eight hundred and fifty chest pain prescriptions were collected, and 88 of them contained eighteen incompatible medicaments, taking 10.3% of all; the applications of ancient and modern chest pain prescriptions containing eighteen incompatible medicaments are significant difference (P < 0.05). Ancient formulas, mainly focus on the eastern jin dynasty and tang dynasty, are more often used than the modern formulas. The most common anti-drugs is on the Fuzi-Pinellia, Chuanwu-Pinellia; the property and flavor of drugs is bitter cold most closely; the decoction of the formulas is mostly used.</p><p><b>CONCLUSION</b>Eighteen incompatible medicaments account for about ten percent of the chest pain prescription, not an uncommon side. There are certain rules for application of anti-drug compatibility to treat chest pain.</p>
