Comparing performance measures and clinical outcomes between mobile stroke units and usual care in underserved areas.

BACKGROUND: The efficacy of mobile stroke units (MSUs) in improving acute ischemic stroke (AIS) care in developing countries is unknown. We compared performance measures and stroke outcomes in AIS patients between MSU and usual care: emergency medical services (EMS) and walk-in. METHODS: We enrolled patients > 18 years of age with an AIS within 4.5 h after onset. Demographic data, types, and time of reperfusion therapies and clinical outcomes were recorded. A favorable outcome was defined as a modified Rankin Scale (mRS) 0-2 at 3 months. RESULTS: A total of 978 AIS patients (MSU = 243, EMS = 214, walk-in = 521) were enrolled between June 1, 2018, and April 30, 2021. The mean age (± SD) was 66 (± 14) years, and 510 (52.1%) were male. AIS time metrics were the shortest in the MSU with a mean (± SD) door to needle (DN) time of 20 (± 7), 29 (± 13), and 35 (± 16) min (p < 0.001) and door to puncture (DP) time of 73 ± 19, 86 ± 33, and 101 ± 42 min (p < 0.001) in MSU, EMS, and walk-in, respectively. Participants in the MSU (56.8%) received higher rate of reperfusion therapie(s) when compared to the EMS (51.4%) and walk-in (31.5%) (p < 0.001). After adjustment for any potential confounders and using the EMS as a reference, the MSU has the highest likelihood of achieving a favorable outcome (adjusted OR 2.15; 95% CI 1.39-3.32). CONCLUSIONS: In underserved populations, MSUs significantly reduced DN time, increased the likelihood of receiving reperfusion treatment, and achieved independency at 3 months when compared to usual care.

Effects of Different Montages of Transcranial Direct Current Stimulation on Haemodynamic Responses and Motor Performance in Acute Stroke: A Randomized Controlled Trial.

OBJECTIVE: Transcranial direct current stimulation (tDCS) has shown positive results in neurorehabilitation. However, there is limited evidence on its use in acute stroke, and unclear evidence regarding the best tDCS montage (anodal-, cathodal-, or dualtDCS) for stroke recovery. This study investigated the effects of these montages combined with physical therapy on haemodynamic response and motor performance. METHODS: Eighty-two eligible acute stroke participants were allocated randomly into anodal, cathodal, dual, and sham groups. They received 5 consecutive sessions of tDCS combined with physical therapy for 5 days. Cerebral mean blood flow velocity (MFV) and motor outcomes were assessed pre and post-intervention and at a 1-month follow-up. RESULTS: None of the groups showed significant changes in the MFV in the lesioned or non-lesioned hemispheres immediately post-intervention or at a 1-month follow-up. For motor performance, all outcomes improved over time for all groups; between-group comparisons showed that the dual-tDCS group had significantly greater improvement than the other groups for most of the lower-limb performance measures. All 5-day tDCS montages were safe. CONCLUSION: MFV was not modulated following active or sham groups. However, dual-tDCS was more efficient in improving motor performance than other groups, especially for lower-limb performance, with after-effects lasting at least 1 month.

Improvement of Gait Symmetry in Patients with Stroke by Motor Imagery.

OBJECTIVE: To investigate effect of gait training with motor imagery (MI) on gait symmetry and self-efficacy offalling in stroke patients. MATERIAL AND METHOD: Fourteen stroke patients were categorized in the MI (n = 7) and control (n = 7) groups. They were matched by age range, stroke type, paretic side, time since stroke, and severity. All participants received physical therapy and only the MI group received additional MI training. Both groups were trained for 12 sessions over 1 month. Outcome measurements comprised gait symmetry detecting by theforce distribution measurement platform and self-efficacy offalling testing by the Fall Efficacy Scale-International (FES-I). Both groups were assessed three times:.pre-, intermediate- and post-trainings. Comparisons of all variables between and within groups were tested by Mann-Whitney U test and Friedman ANOVA test, respectively. RESULTS: No significant difference was observed of gait symmetry between MI and control groups. Within group comparison, tendencies of improvement were found in step length and step time symmetry for the MI group. Significant improvements in step length symmetry and FES-I score were found among assessments for the MI group (p<0.05). CONCLUSION: Gait training with MI enhanced ability of step length symmetry and decreased fear offalling in patients with stroke.

Relationship between ankle brachial index (ABI), high sensitivity C-reactive protein (hs-CRP) and initial disability level in acute ischemic stroke.

BACKGROUND: Relationship between high sensitivity C-reactive protein (hs-CRP), Ankle Brachial index (ABI), severity of atherosclerosis and risk of ischemic stroke has been well documented. Studies concerning the association of ABI, hs-CRP and initial disability level in acute ischemic stroke are scarce. OBJECTIVE: This study aimed to investigate the relationship between hs-CRP, ABI and level of initial disability in acute stroke setting. MATERIAL AND METHOD: We conducted a prospective observational study in patients with acute ischemic stroke within 48 hours of onset. Initial ABI, hs-CRP were measured. Disability level was assessed at admission and 3 months using the modified Rankin scale (mRS) and the National Institue of Health Stroke scale (NIHSS). Statistical analysis was performed using Pearson's correlation coefficient. RESULTS: This study included 36 patients with a mean +/-SD age of 67.8 +/- 9.3 years. Sixteen (44.4%) were male. Median NIHSS and mRS were 10 and 4 respectively. Correlation between initial ABI and hs-CRP was poor (r(s) = -0.11, p = 0.57). There was a significant negative relationship between ABI and mRS at 0 and 3 months with a correlation coefficient of -0.45 (p = 0.006) and -0.41 (p = 0.02), respectively. CONCLUSION: There was a significant inverse relationship between ABI and initial stroke disability. However, correlation coefficient indicated only fair agreement beyond chance. This findings suggest that ABI may be used as a clinical predictor of initial disability level in acute stroke.

Optic-spinal inflammatory demyelinating disease: (OS-IDD) patients in Siriraj Hospital.

OBJECTIVE: To study the demographic data of optico-spinal inflammatory demyelinating disease (OS-IDD) patients at Siriraj Hospital between January 1997 and October 2006. DESIGN: Retrospective study of OS-IDD patients. RESULTS: There were 84 OS-IDD patients. Cerebrospinal fluid analysis revealed higher white blood cell count and neutrophilia in neuromyelitis optica (NMO) patients than those of multiple sclerosis (MS) patients. NMO had an average length of 4.1 segments of the cervical and 6.5 segments of thoracic cord involvement. CONCLUSION: Among Thai OS-IDD patients, on the basis of clinical features, NMO was hardly differentiated from MS.