Human health risk assessment of heavy metals in vegetables of Bangladesh.

This study aims to evaluate the heavy metal concentration in fifteen species of vegetables as well as associated health risk. Atomic absorption spectrometry is used to assess heavy metals. The mean concentrations of Pb, Cd, Cr, Ni and Fe in vegetables were 4.78, 0.713, 9.266, 0.083, 5.06 mg/kg/fw exceeding the reference value of FAO/WHO indicating unsafe to consumption. Based on principal component analysis, the Pb, Cr, Ni and Fe are from same sources. Health risk was estimated in terms of estimated daily intake (EDI), target hazard quotient, hazard index (HI) and cancer risk (CR). The EDI values of metals except Cr were found to be lower than maximum tolerable daily intake (MTDI). The total THQs of metals were > 1 indicating non-carcinogenic health risk. The individual HI values for vegetables except potato (0.831) and total HI values were found to be > 1 (94.747). The TCR of Pb, Cd and Cr were > 1.0E-04 which indicating carcinogenic risk. Fruit and pod vegetables contribute much in carcinogenic risk for Pb and Cr whereas fruit, root and stems vegetables for Cd. The study revealed potential human health risk associated with the consumption of different types of vegetables in Bangladeshi adult population that might assist the regulatory bodies to develop new strategies to minimize the risk to human.

Health effects of heavy metals in meat and poultry consumption in Noakhali, Bangladesh.

This study examined the quantities of heavy metals (Cd, Cr, Pb, Ni, Fe, and Cu) in commercially available meat, poultry, and game products in Noakhali, Bangladesh, and their potential health effects, as heavy metal contamination poses a significant food safety risk to human health Atomic Absorption Spectrophotometry was used to analyze heavy metals, and the health risk assessment was based on Estimated Daily Intake (EDI), Targeted Hazard Quotient (THQ), Total THQ, and Total Carcinogenic Risk (TCR). Most samples exceeded Maximum Allowable Concentrations (MAC) for heavy metals. The EDI value of Cd, Pb, and Cr for duck liver, goat liver, and pigeon brain, were higher than the Maximum Tolerable Dietary Intake (MTDI). Children had 1.28 times higher HI values than an adult. The calculation of THQ of all elements in adults and children was in the order of Cu; Pb; Ni; Cr; Cd; and Fe. The calculated TTHQ values were in the range of 0.051 to 1.988 and 0.047 to 3.975 for adults and children, respectively. The TCR values for Cd in poultry liver, brain, and meat, Sonali chicken, cow, pigeon, duck, and goat liver were higher than the reference value for adults and children, suggesting a potential cancer risk. The average exposure to lead leads to an increase in blood pressure by 0.47 mmHg and a decrease in IQ score by 1.94 points. The present study reveals the need to determine strong relationships between heavy metal exposure and food supply.

Heavy metals induced health risk assessment through consumption of selected commercially available spices in Noakhali district of Bangladesh.

There are growing concerns for food safety due to the risks associated with heavy metal contamination of culinary herbs and spices in developing countries like Bangladesh. The objective of the present cross-sectional study is to determine the concentrations of the heavy metals Lead (Pb), Cadmium (Cd), Chromium (Cr), Copper (Cu), and Iron (Fe) in the branded and non-branded spices collected from the Noakhali district by Atomic absorption spectrophotometry method, as well as to assess the health hazard risk associated with heavy metals intake via consumption of spices. The findings revealed that the greatest concentrations of Pb (15.47 ± 1.93), Cd (1.65 ± 0.011), Cr (31.99 ± 3.97), Cu (18.84 ± 1.97), and Fe (9.29 ± 1.71) were found in Cardamom, Coriander leaf, Bay leaf, Dried chili, and Black pepper respectively. Around 37 % of Cr and 5 % of Fe Estimated Daily Intake (EDI) were greater than reference doses (RfD). All spices had Total Hazard Quotient (THQ) values for Pb, Cd, Cu, and Fe that were below acceptable, and 37 % of all spices had Total Target Hazard Quotient (TTHQ) values for Pb, Cd, Cu, and Fe that were over the standard range, suggesting adverse health impacts for consumers. Green chili, ginger, coriander leaf, and all kinds of chili powder and turmeric powder have been reported to have exceptionally high TTHQ levels of Cr. The estimated carcinogenic risk for chromium in non-branded coriander leaf was found to be higher than safe levels. This study provides valuable insights into the commonly consumed spices in Bangladesh and their potential health risks associated with heavy metal contamination. The findings of this study can be used by regulatory authorities to develop effective strategies and actions to mitigate these risks and safeguard public health.

Coping with the COVID-19 pandemic by strengthening immunity as a nonpharmaceutical intervention: A major public health challenge.

Background and Aims: The global Coronavirus-2 outbreak has emerged as a significant threat to majority of individuals around the world. The most effective solution for addressing this viral outbreak is through vaccination. Simultaneously, the virus's mutation capabilities pose a potential risk to the effectiveness of both vaccines and, in certain instances, newly developed drugs. Conversely, the human body's immune system exhibits a robust ability to combat viral outbreaks with substantial confidence, as evidenced by the ratio of fatalities to affected individuals worldwide. Hence, an alternative strategy to mitigate this pandemic could involve enhancing the immune system's resilience. Methods: The research objective of the review is to acquire a comprehensive understanding of the role of inflammation and immunity in COVID-19. The pertinent literature concerning immune system functions, the impact of inflammation against viruses like SARS-CoV-2, and the connection between nutritional interventions, inflammation, and immunity was systematically explored. Results: Enhancing immune function involves mitigating the impact of key factors that negatively influence the immune response. Strengthening the immune system against emerging diseases can be achieved through nonpharmaceutical measures such as maintaining a balanced nutrition, engaging in regular exercise, ensuring adequate sleep, and managing stress. Conclusion: This review aims to convey the significance of and provide recommendations for immune-strengthening strategies amidst the ongoing COVID-19 pandemic.

Assessing Nutritional Status and Functionality in Geriatric Population of Bangladesh: The Hidden Epidemic of Geriatric Malnutrition.

The average life expectancy of the Bangladeshi population has risen over the last decade due to economic growth and improved medical care. Although the increased number of older adults and their health is a significant concern, there is scarce of data regarding that. A community-based cross-sectional study was conducted to analyze the association between nutritional status and functional ability among selected Bangladeshi geriatric populations living in their homes. Of 400 participants, the prevalence of malnutrition, and people at risk of malnutrition was 25.4% and 58.8%, respectively. Furthermore, almost 80% of participants are dependent in terms of activities of daily living. High risk of falling (OR = 10.82; 95% CI: 5.85-20.37; p ≤ .001), limited activities of daily living (IADL) (OR = 6.21; 95% CI: 4.02-9.58; p ≤ .001), along with dependency in performing IADL (OR = 4.48; 95% CI: 2.83-7.06; p ≤ .001) are significantly associated with malnutrition. Geriatric malnutrition can accelerate disability conditions, leading to early functional aging.

Knowledge, attitudes, and practices (KAP) of nutrition among school teachers in Bangladesh: A cross-sectional study.

BACKGROUND: Teachers play a pivotal role in imparting nutritional knowledge to their students. This research aimed to evaluate the nutrition-related knowledge, attitudes, and practices (KAP) of selected Bangladeshi school teachers across the country. METHODS: A cross-sectional study was performed using a multistage sampling method. A pretested and structured questionnaire was used to collect data. Statistical analyses, including descriptive statistics, multiple regression analysis, and ANOVA tests, were performed to carry out the study. RESULTS: Among the 280 participants, only 9.9% were happy with their understanding of childhood nutrition requirements, around 54.2% were familiar with basic nutrition-related knowledge, and overall, 97.7% of participants had a positive attitude towards learning about nutrition-related knowledge focusing on the well-being of children. Moreover, only 38.7% had training in pediatric nutrition. Age, type of school, type of residence, professional training of school teachers, and the intent of having ever taken part or paying attention to nutrition-related knowledge significantly impacted the respondents' nutrition knowledge score (p<0.05). CONCLUSION: Adequate planning and intervention measures should be developed to improve teachers' understanding, behavior, and practice that encourage the growth of optimal nutrition-related behavior among school-aged children to establish a healthy nation.

Current knowledge, attitude, and practice (KAP) towards physical activity (PA) and its impact on obesity management in Bangladesh: A cross-sectional study.

Background and Aims: The purpose of this study was to evaluate the Bangladeshi people's current knowledge, attitude, and practice (KAP) on obesity and physical activity (PA), as well as the associated factors. Methods: The KAP was evaluated using a standard questionnaire among 429 individuals, of whom 75.5% were men and had a mean age (±SD) of 28.9 ± 7.9 years. Using a mobile-based KoBo toolbox v.25.0 program, information was gathered from respondents who resided in various districts. A Chi-square test and a linear regression test were performed to determine the relationship between the variables, and a one-way analysis of variance (ANOVA) was conducted to the determine differences in means. Results: The study showed that more than 95% of participants had good knowledge level, although the attitude and practice levels were low. Based on ANOVA test, the mean knowledge score was significantly different (p < 0.05) with age, marital status, and education; attitude levels with education and body mass index (BMI); and practice levels with education, residence, marital status, and BMI. Linear regression analysis exhibited: the level of knowledge was associated with age (ß = -5.34), BMI (ß = 3.67), and attitude (ß = 0.46) while the level of attitude was associated with education (ß = 2.26), BMI (ß = -2.42), knowledge (ß = 0.2) and practice levels (ß = 0.18); and finally, the level of practice was associated with education (ß = -3.29), BMI (ß = -4.5) and attitude (ß = 0.35). Conclusion: The increased prevalence of obesity among the Bangladeshi population was indicated by optimal levels of knowledge but inadequate levels of attitude and practice toward PA. So, proper initiatives should be taken to educate people on the importance of regular PA to manage obesity by policymakers and the government.

Knowledge, attitudes, and predictors of exclusive breastfeeding practice among lactating mothers in Noakhali, Bangladesh.

Background: Mothers' knowledge, attitudes, and practices toward exclusive breastfeeding are crucial to both child and mother's health and wellbeing. Hence, This study aimed to assess knowledge, attitudes, and practices of exclusive breastfeeding among lactating mothers as well as the predictors of their exclusive breastfeeding practice. Methodology: This cross-sectional study included 397 mothers having infants aged 0-6 months who sought care at Noakhali Sadar Upazila, Noakhali, Bangladesh. A field-tested and validated Food and Agriculture Organization of the United Nations (FAO) questionnaire was utilized to collect information from participants. Results: Of those evaluated; 29.0% of mothers could not define exclusive breastfeeding accurately, 11.3% and 59.3% did not know the benefits of exclusive breastfeeding for babies and mothers, respectively. More than half (51.4%) of the mothers reported feeling good about exclusive breastfeeding for six months, did not find difficulties to breastfeed exclusively for six months (39.5%) and on-demand (58.2%). The mothers had an overall favorable attitude towards exclusive breastfeeding; however, 38.3% of mothers did not exclusively breastfeed their children. Literate mothers tended to exclusively breastfeed more (AOR: 3.06, 95% CI: 1.01-9.32; P = 0.049) than illiterate mothers. Mothers having one baby were more likely to breastfeed exclusively (AOR: 3.07, 95% CI: 1.21-7.78; P = 0.018) than mothers having more than one baby. Moreover, mothers with higher knowledge and favorable attitude had more than two times (AOR: 2.58, 95% CI: 1.315.07; P = 0.006) and forty-three times (AOR: 43.18, 95% CI: 21.513-86.66; P < 0.001) the higher tendency of exclusive breastfeeding compared to others. Conclusion: Despite having satisfactory knowledge and attitude, the practice of exclusive breastfeeding among mothers was poor. We recommend that interventions must be focused more on ensuring exclusive breastfeeding practice among mothers in addition to improving their knowledge and attitudes.

Effect of stevia leaves (Stevia rebaudiana Bertoni) on diabetes: A systematic review and meta-analysis of preclinical studies.

Stevia (Stevia rebaudiana Bertoni) is a natural herb with biological activities such as anticancer, antidiabetic, anticardiovascular disease, anti-inflammatory, and antimicrobial. The current systematic review and meta-analysis of previously published data were performed to assess the antidiabetic effect of stevia leaves. Three electronic databases (PubMed, CENTRAL, and DOAJ) had been used for searching articles published before September 2020. Meta-analysis via random-effect model had been performed to assess the effects of different doses of stevia on blood glucose level (BGL) and studies were weighted according to an estimate of the standard mean difference (SMD). Overall, 16 eligible studies were selected for qualitative analysis and 9 were included for quantitative analysis. The results of the meta-analysis for BGL showed that at the doses of 200, 300, and 400 mg/kg of stevia leaves there was a significant difference in means of BGL between the intervention and control group and the dose of 500 mg/kg showed no significance (Standard mean difference (SMD): -3.84 (-9.96, 2.27); p = .22). Based on the duration of intervention, subgroup analysis of articles showed a significant difference between the groups (p < .001). The results of the meta-analysis support the hypothesis that stevia leaf has an antihyperglycemic effect and reduces the blood glucose level at doses of 200, 300, and 400 mg/kg. Therefore, more clinical trials on animals and humans have to be done to investigate the antidiabetic and antihyperglycemic effects along with the efficacy and safety of these medicinal leaves.

Lentil allergens identification and quantification: An update from omics perspective.

Among legumes, the lentil (Lens culinaris) is a major dietary component in many Mediterranean and Asian countries due to its high nutritional value, especially protein. However, allergic reactions triggered by lentil consumption have also been documented in many countries. Complete allergens profiling is critical for better management of lentil food allergies. Earlier studies suggested Len c 1, a 47 kDa vicilin, Len c 2, a seed-specific-biotinylated 66-kDa protein, and Len c 3, low molecular weight lipid transfer proteins (LTPs) were major allergenic proteins in lentils. Recently, mass-spectrometry-based proteomic platforms successfully identified proteins from lentil samples homologous to known plant allergens. Furthermore, in silico analysis using 337 protein sequences revealed lentil allergens that have not previously been identified as potential allergens in lentil. Herein, we discuss the feasibility of omics platforms utilized for lentil allergens profiling and quantification. In addition, we propose some future strategies that might be beneficial for profiling and development of precise assays for lentil allergens and could facilitate identification of the low allergen-containing lentil cultivars.

Balanced diet related knowledge, attitude and practices (KAP) among adolescent school girls in Noakhali district, Bangladesh: a cross sectional study.

OBJECTIVES: Adolescence, a crucial period for growth velocity including sexual maturation, is an important period of life and young adolescent girls need to have proper knowledge, positive attitudes and practice of balanced diet to achieve optimum growth and development. Considering its importance this study attempts to assess the knowledge, attitude and practice (KAP) of balanced diets among adolescent schoolgirls in Noakhali district, Bangladesh. METHODS: A descriptive cross-sectional study was conducted in three secondary schools in Noakhali district, Bangladesh. A multistage sampling techniques was used to select schools and study participants. A total of 485 adolescent school girls participated and a pre-designed, validated and structured questionnaire was used for data collection. In addition to descriptive statistics, chi-square test and logistic regression were employed for analysis. RESULTS: The results from the study revealed that more than half of the students did not have good knowledge about a balanced diet, 42.8% had a positive attitude, whereas the practice of consuming a balanced diet was rather low (only 4.5%). Students studying in government schools had better knowledge and attitudes than non-government school students. Moreover, 41.1% of students were underweight; more than 60% of respondent's mothers did not have an education higher than secondary school and were mostly unemployed housewives. Parent's education, mother's occupation, and types of school have a strong association with KAP; however, father's education and occupation showed an association of varying degrees. Being knowledgeable was related to positive attitudes, and students with good knowledge had (OR: 1.828; 95% CI: 1.270-2.631) more likely to have positive attitudes towards a balanced diet. CONCLUSIONS: Thus, proper knowledge about a balanced diet should be introduced with basic nutritional knowledge to all levels of public education. Interventions and programs can be designed to improve knowledge, attitude, and more specifically the practice at the household level so that adolescent girls can have a proper diet during their sexual maturation phase.

Psychosocial Impact of COVID-19 among Young Bangladeshi Adults (18-34 years): An Online-Based Cross-Sectional Study.

OBJECTIVES: COVID-19 pandemic is at the fourth stage of boundless local transmission in Bangladesh. The objective of this study was to assess the psychosocial impact of COVID-19 on adult Bangladeshi population. DESIGN: Online-based cross-sectional study. SETTINGS: Data were collected from different parts of the Bangladesh. PARTICIPANTS: Information was collected from 213 young adults who were aged 18-34 years old using convenient sampling technique. RESULTS: More than 90% of participants were responded to possess a good awareness of COVID-19. However, the behavioral characteristics of young individuals in Bangladesh were not impressive. In this cohort, 24.4% of participants showed moderate change and 5.2%-little changes in their behavior due to COVID-19. Approximately 58.2% of participants had some symptoms of mental distress while 59.7% of participants were somewhat worried about COVID-19. CONCLUSION: In order to control the spread of Covid-19, existing unconsciousness in young adult could turn this situation into a disaster throughout the nation which therefore must be understood by the government and policymakers to incorporate successful measures.

Does higher body mass index increase COVID-19 severity? A systematic review and meta-analysis.

INTRODUCTION: Obesity and higher BMI is one of the leading comorbidities to increase the risk of COVID-19 severity. This paper presents a systematic review and meta-analysis estimating the effects of overweight and obesity on COVID-19 disease severity. METHOD: Two electronic databases (Medline and Cochrane library) and one grey literature database (Grey Literature Report) were searched. The risks of bias of the selected studies were assessed by using the Navigation Guide method for human data. Both random and fixed effect meta-analyses were determined using Review Manager (RevMan) software version 5.4. RESULTS: After initial screening, 12 studies were fulfilled the eligibility criteria, comprising a total of 405359 patients, and included in the systematic review. The pooled risk of COVID-19 severity was 1.31 times higher based on both fixed and random effect model among those overweight patients, I 2 0% and 2.09 and 2.41 times higher based on fixed and random effect respectively among obese patients, I 2 42% compared to healthy individuals. CONCLUSION: Overweight and obesity are found to be risk factors for disease severity of COVID-19 patients. However, further assessment of metabolic parameters is required to estimate the risk factors of COVID-19 patients and understanding the mechanism between COVID-19 and body mass index.

Prevalence of insomnia among university students in South Asian Region: a systematic review of studies.

INTRODUCTION: Insomnia is a global health problem among university students which is associated with various psychiatric problems like depression and anxiety. While different developed and developing countries assessed the prevalence of insomnia in youth, currently there is hardly systematic review of studies found based on the prevalence of insomnia in South Asia. AIMS: The aim of this study is to systematically review the evidence relating to the prevalence rate of insomnia in university students in South Asian countries. METHODS: Electronic searches of three databases, PubMed, Cochrane library, and Worldwide science were performed from 2010 to 2020 before April. In total, seven studies were included for evaluating insomnia in South Asian region among university students. RESULTS: The prevalence rates of insomnia of the seven studies ranged between 35.4% (95% CI: 32.4-38.5%) and 70% (95% CI: 65.7-74.1%). The pooled prevalence of insomnia among university students was 52.1% (95% CI: 41.1-63.1%). CONCLUSIONS: This review emphasized that insomnia in university students might be a common health issue to give full concentration in their studies and academic performance. Thus, more attention should be given to the determinants of insomnia among university students, so that it could be helpful to identify the main causes of insomnia and effective measures could be taken.