RESUMO
Hypothyroidism is a rare cause of pericardial effusion (PE). Pericardial effusion secondary to hypothyroidism remains a diagnostic challenge for clinicians because of its inconsistency between symptoms and amount of pericardial effusion. We report an atypical case that presented with ascites and was diagnosed to have cardiac tamponade secondary to primary hypothyroidism. Besides repeated pericardiocentesis she eventually required surgical management and optimization of medical therapy to manage the massive pericardial effusion.
Assuntos
Tamponamento Cardíaco/etiologia , Hipotireoidismo/complicações , Derrame Pericárdico/etiologia , Adulto , Feminino , Humanos , Hipotireoidismo/diagnósticoRESUMO
A facile stereoselective synthesis of (Z)- and (E)-allyl sulfides has been accomplished from Morita-Baylis-Hillman acetates in one-pot by treatment with benzene thiol in the presence of catalytic amounts of 15% aqueous NaOH and TBAI in DMSO at room temperature. The method has been applied for the synthesis of (Z)-3-(4-methoxybenzylidene)thiochroman-4-one, a potent antifungal compound.
Assuntos
Compostos Alílicos/síntese química , Compostos Alílicos/farmacologia , Antifúngicos/síntese química , Antifúngicos/farmacologia , Cromanos/síntese química , Acetatos/química , Catálise , Cromanos/farmacologia , Ciclização , Dimetil Sulfóxido , Indicadores e Reagentes , Espectroscopia de Ressonância Magnética , Hidróxido de Sódio , Solventes , Espectrometria de Massas de Bombardeamento Rápido de Átomos , Espectrofotometria Infravermelho , Estereoisomerismo , Sulfetos/síntese química , Sulfetos/farmacologiaRESUMO
An efficient and solely stereoselective synthesis of (E)-alpha-methylcinnamic acids has been accomplished in single pot by reduction of the unmodified Baylis-Hillman adducts, methyl-3-hydroxy-3-aryl-2-methylenepropanoates with I(2)/NaBH(4) reagent system at room temperature followed by hydrolysis. The efficacy of this method has been proved in the total synthesis of 1-[p-(myristyloxy)-alpha-methylcinnamoyl]glycerol, LK-903, a highly active hypolipidemic agent.
Assuntos
Cinamatos/síntese química , Glicerídeos/síntese química , Hipolipemiantes/síntese química , Estrutura MolecularRESUMO
2-Benzoxepines have efficiently been synthesized from Morita-Baylis-Hillman adducts, alkyl 3-aryl-3-hydroxy-2-methylenepropanoates by treatment with HCHO catalyzed by silica supported perchloric acid (HClO4.SiO2) or Amberlyst-15 in CH2Cl2 under reflux for a short period of time (1.5-2.5 h). The catalyst can be recovered and recycled. The antibacterial properties of the new 2-benzoxepines were studied but no activity was found.
