MUC-1 recognition-based activated drug nanoplatform improves doxorubicin chemotherapy in breast cancer.

Tumor-targeted drug delivery systems with stimuli-response drug release have been increasingly used to improve the therapeutic efficacy of antitumor drugs. Here, we report a specific molecular recognition activation drug nanoplatform based on specially designed DNA sensor-capped doxorubicin (DOX)-loaded mesoporous silica nanoparticles (MSNs), designated as specific molecular recognition-activated nanoparticle (SMRAN). DNA sensors on the targeted nanoparticles can trigger DOX release through a conformational switch induced by MUC-1. This causes a significant difference in cell viability between breast cancer MCF-7 and normal breast Hs578bst cells (24.8% and 86.0%). In vivo experiments showed that the tumor volume was reduced 1.5-times in the SMRAN treatment group. Compared with that in the DOX group, due to significantly improved tumor accumulation and retention of DOX. The strategy of the MUC-1 activated drug delivery system is expected to provide a new perspective for clinical application.

Insights into the interplay between electric fields and microstructures of AEL films under ionothermal conditions.

A facile method for precise microstructure control of molecular sieve films remains a great challenge. In contrast to conventional hydrothermal methods, herein AEL molecular sieve films with preferred c-orientation are in situ fabricated through elaborate programming of the applied electric fields under ionothermal conditions. The approach developed here may pave a new avenue for designing and fabricating high quality molecular sieve films with diverse microstructures and functionality.

In†Situ Electrochemical Synthesis of Oriented and Defect-Free AEL Molecular-Sieve Films Using Ionic Liquids.

Simply preparing oriented and defect-free molecular-sieve films have been a long-standing challenge both in academia and industry. Most of the early works focus on the careful and multiple controls of the seeds layer or synthesis conditions. Herein, we report a one-step in situ electrochemical ionothermal method that combines a controllable electric field with ionic liquids. We demonstrate that an in-plane oriented and defect-free AEL (one molecular-sieve framework type) molecular-sieve film was obtained using an Al electrode as the Al source. The excellent corrosion-resistant performance of the film makes this technology promising in multiple applications, such as anti-corrosion coatings.

Acrylic acid and electric power cogeneration in an SOFC reactor.

A highly efficient catalyst, MoV(0.3)Te(0.17)Nb(0.12)O, used for acrylic acid (AA) production from propane, was used as an anodic catalyst in an SOFC reactor, from which AA and electric power were cogenerated at 400-450 degrees C.