Glaucoma diagnostic performance of macular ganglion cell complex thickness using regular and long axial length normative databases.

The risks of misdiagnosing a healthy individual as glaucomatous or vice versa may be high in a population with a large majority of highly myopic individuals, due to considerable morphologic variability in high myopic fundus. This study aims to compare the diagnostic ability of the regular and long axial length databases in the RS-3000 Advance SD-OCT (Nidek) device to correctly diagnose glaucoma with high myopia. Patients with high myopia (axial length ≥ 26.0 mm) in Chang Gung Memorial Hospital, Taiwan between 2015 and 2020 were included. Glaucoma was diagnosed based on glaucomatous discs, visual field defects and corresponding retinal nerve fiber layer defects. The sensitivity, specificity, diagnostic accuracy and likelihood ratios of diagnosing glaucoma via mGCC thickness in both superior/inferior and GChart mapping using the regular and long axial length normative databases. The specificity and diagnostic accuracy of mGCC thickness for distinguishing glaucomatous eyes from nonglaucomatous eyes among highly myopic eyes were significantly improved using the long axial length database (p = 0.046). There were also significant proportion changes in S/I mapping as well as GChart mapping (37.3% and 48.0%, respectively; p < 0.01) from abnormal to normal in the myopic normal eye group when using the long axial length normative database. The study revealed that clinicians could utilize a long axial length database to effectively decrease the number of false-positive diagnoses or to correctly identify highly myopic normal eyes misdiagnosed as glaucomatous eyes.

Surgical removal of the internal limiting membrane for the treatment of a macular hole.

BACKGROUND: To evaluate the efficacy of internal limiting membrane (ILM) peeling in the treatment of a macular hole. METHODS: The ocular evaluation included Snellen visual acuity, a slit-lamp examination, indirect ophthalmoscopy, and contact lens biomicroscopy. The macular holes were confirmed using a Watzke-Allen slit beam test. Surgery consisted of a standard 3-port vitrectomy under local anesthesia. The vitreous was removed, and the macular ILM was peeled by creating a small opening and a tear in the ILM with a bent 22-gauge needle around the inner margin of the vascular arcade. The ILM flap was then grasped with end-gripping forceps, and a circular capsulorrhesis maneuver was initiated. Next, gas-fluid exchange and internal tamponade with 10% C3F8 were performed, followed by postoperative face-down positioning. RESULTS: Thirty-six eyes in 36 patients with idiopathic macular holes from stages 2 to 4 were included. The average follow-up time was 8.9 months. The holes were completely closed in 33 eyes (92%), and visual acuity was improved in 26 eyes (72%). Ten eyes were pseudophakic, 24 of the 26 phakic eyes had an increased density of the cataract after surgery, which was not detected in 2 cases. One of the patients had vitreous hemorrhage and hyphema; no retinal detachment or retinal tear was found in this study. CONCLUSION: Surgery for macular holes using ILM peeling has a high anatomical and functional success rate.