RESUMO
We studied allergenic, immunogenic, and skin-irritating effects of deicing chemicals HCM (Volgograd), Bishofit (Turkmenia), and Nordix-P (Russia) in model experiments on various types of laboratory animals (rats, mice, rabbits). All the studied deicing chemicals exhibited weak immunotoxic activity and in high doses can cause delayed-type hypersensitivity reaction that manifested in skin irritant effect on the skin and produced a suppressive effect on the humoral immunity. The modified method for assessing skin irritation proposed by us is more sensitive than standard methods.
Assuntos
Alérgenos/farmacologia , Glicerol/farmacologia , Hipersensibilidade Tardia/induzido quimicamente , Irritantes/farmacologia , Sais/farmacologia , Animais , Feminino , Cobaias , Humanos , Hipersensibilidade Tardia/imunologia , Imunidade Humoral/efeitos dos fármacos , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Coelhos , Ratos , Federação Russa , Pele/efeitos dos fármacos , Pele/imunologia , Meios de TransporteRESUMO
The experimental study of the biological activity of the modified calcium chloride produced by a Volgograd plant and that of ash-and-slag of the pharmaceuticals resulting after combustion of a pyrolytic mixture of filtration burning could establish various hazards of these substances.
