RESUMO
Mexidol effectiveness was tried in acute pancreatitis (AP). It was found that in acute pancreatitis mexidol provides a reliable defence of membrane structures, decreased the rate of lipid peroxidation, enhanced the activity of the antioxidative system. This eventually results in reduced number of AP complications (by 9-13%) and mortality (by 7%). In AP mexidol should be injected intraductally.
Assuntos
Antioxidantes/uso terapêutico , Pancreatite/tratamento farmacológico , Picolinas/uso terapêutico , Doença Aguda , Adulto , Idoso , Amilases/sangue , Antioxidantes/administração & dosagem , Ensaios Enzimáticos Clínicos , Feminino , Humanos , Lipase/sangue , Peroxidação de Lipídeos , Masculino , Pessoa de Meia-Idade , Pancreatite/diagnóstico , Pancreatite/mortalidade , Picolinas/administração & dosagem , Fatores de Tempo , Tripsina/sangueRESUMO
Donor plasma exposed to UV rays was included in the complex of measures for the treatment of diffuse pancreonecrosis with marked signs of enzyme toxemia and endogenous intoxication in 14 patients. The irradiation was conducted on an original device in which a [symbol: see text] lamp with a wave length of 253.6 nm was used as the source of radiation. Study of the dynamics of changes in the level of lipid peroxidation, alpha-tocopherol, trypsin, and lipase allows the conclusion that infusion of donor plasma exposed to UV radiation has a favorable effect on processes of detoxification of the organism.
Assuntos
Transfusão de Componentes Sanguíneos/métodos , Pancreatite/terapia , Plasma , Raios Ultravioleta , Adulto , Idoso , Diagnóstico Diferencial , Feminino , Humanos , Laparoscopia , Lipase/sangue , Peroxidação de Lipídeos , Masculino , Pessoa de Meia-Idade , Pancreatite/sangue , Pancreatite/diagnóstico , Plasma/efeitos da radiação , Resultado do Tratamento , Tripsina/sangue , Vitamina E/sangueRESUMO
The method of intraductal administration of ribonuclease as a therapeutic measure was developed on an experimental model of acute pancreatitis in albino rats. Morphological and biochemical examination showed that intraductal administration of ribonuclease in a dose of 0.5 mg produces a positive therapeutic effect, which allowed the method to be applied in complex treatment of 33 patients with various forms of acute pancreatitis. Administration of ribonuclease into the pancreatic duct relieved the attack of pain and reduced the level of lipo- and proteolytic enzymes in blood. No complications were encountered in endoscopic cannulation of the main pancreatic duct and subsequent administration of ribonuclease.
