[Effect of aminazin, phenobarbital and their combination on the activity of the liver hydroxylase system and on their individual pharmacological effects]. / Vliianie aminazina, fenobarbitala i ikh sochetaniia na aktivnost' gidroksilaznoi sistemy pecheni i na farmakologicheskii éffekt etikh preparatov.

Administration of phenobarbital to male-rats for 4 days induced the appearance of P-450 cytochrome in the liver and intensified the activity of the hydroxylase system, more specifically with respect to hexobarbital than to amidopyrine. The cataleptic effect of chlorpromazine was then running low. A 4-day long administration of chlorpromazine failed to increase the P-450 cytochrome content, but did change the hydroxylating activity of the microsomes in favour of the amidopyrine metabolism. With joint introduction of chlorpromazine and phenobarbital the intensity of the amidopyrine hydroxylation increased to a greater extent.

[Influence of antidepressants on the convulsive action of corazole and strychnine]. / Vliianie antidepressantov na sudorozhnoe deistvie korazola i strikhnina

The influence of 10 antidepressants on an experimentally induced convulsive syndrome in mice was studied. It was found that, as concerns their ability to have an effect on DL50 of metrasol, the depressants may be classified into drugs protecting mice against the action of metrasol (melipramine, amitryptiline, chlorprothixen and phthoracizine), those potentiating the effect of metrasol (insidon, phrenolon, iproniazide, nuredal) and drugs producing no essential effect on DL50 of metrasol (desipramine, sonapax). All of the above drugs had an effect of decreasing the mean lethal dose of strychnine.