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4.
J Eur Acad Dermatol Venereol ; 17(5): 578-80, 2003 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-12941100

RESUMO

Photochemotherapy using psoralen and ultraviolet (UV)A irradiation (PUVA) is a useful treatment method for vitiligo. However, long-term PUVA therapy may cause several adverse effects including skin cancer, especially squamous cell carcinoma (SCC). We describe a case of SCC in vitiligo lesion after long-term PUVA therapy.


Assuntos
Carcinoma de Células Escamosas/etiologia , Terapia PUVA/efeitos adversos , Pênis/patologia , Neoplasias Cutâneas/etiologia , Vitiligo/tratamento farmacológico , Adulto , Biópsia por Agulha , Carcinoma de Células Escamosas/patologia , Seguimentos , Humanos , Imuno-Histoquímica , Assistência de Longa Duração , Masculino , Terapia PUVA/métodos , Medição de Risco , Neoplasias Cutâneas/patologia , Vitiligo/diagnóstico
5.
Korean J Parasitol ; 31(3): 277-83, 1993 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-8241087

RESUMO

Leishmaniasis is one of the important tropical diseases in the world. Although it is not prevalent in Korea, imported cases have been recorded. The karyotype of Leishmania sp. has been observed to be variable by localities or by strains, but the karyotype of a strain is known to be stable. This study was performed to observe if the karyotype of a Leishmania sp. would be changed under some stressful conditions. The karyotype, analyzed by pulsed field gradient gel electrophoresis, was not grossly changed by heat shock, chemotherapeutics, UV illumination, and gamma irradiation. Radiation destroyed the chromosomes mechanically, but subcultured organisms after irradiation showed unaffected karyotype. The present findings suggest that the karyotype of a Leishmania strain is so stable that it is not altered by temporary stimulation with heat, drugs, and radiation.


Assuntos
Anfotericina B/farmacologia , Temperatura Alta , Cariotipagem , Leishmania major/genética , Sulfametoxazol/farmacologia , Trimetoprima/farmacologia , Animais , Raios gama , Leishmania major/efeitos dos fármacos , Leishmania major/efeitos da radiação , Raios Ultravioleta
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