Correlation of CT presentation with histo-differentiation and p53 and Ki67 expressions in gastric cancer / 中国医学科学院学报

<p><b>OBJECTIVE</b>To study the relationship between spiral CT findings and histological differentiation and expressions of p53 and Ki67 in gastric carcinoma.</p><p><b>METHODS</b>Triphasic spiral CT was performed in 158 patients. CT findings included maximal diameter and thickness of tumor in three dimensional CT images, degree of enhancement, mucous situation, lymph nodes, and visceral metastasis were recorded. The expressions of p53 and Ki67 were detected with immunohistochemistry and reverse transcription polymerase chain reaction.</p><p><b>RESULTS</b>The thickness of tumor (chi2 = 5.554, P = 0.018), degree of enhancement (chi2 = 4.978, P = 0.026), and lymph nodes metastasis (chi2 = 6.061, P = 0.014) in the three dimensional CT images were significantly correlated with tumor histological differentiation. Lymph nodes metastasis was significantly correlated with the expression of p53 (chi2 = 5.028, P = 0.025). The expression of Ki67 was significantly correlated with the thickness of tumor (chi2 = 5.674, P = 0.017) and lymph nodes metastasis (chi2 = 5.028, P = 0.025).</p><p><b>CONCLUSION</b>Multi-slice CT is a simple and noninvasive technique, and can be used for assessing the histological differentiation of gastric cancer as well as the expressions of p53 and Ki67 before the operation.</p>

Value of multi slice spiral computed tomography in diagnosing lymph node metastasis of gastric cancer / 中国医学科学院学报

<p><b>OBJECTIVE</b>To study the value of multi-slice spiral computed tomography (CT) in the preoperative evaluation of lymph node metastasis.</p><p><b>METHODS</b>Totally 45 patients with gastric cancer detected by 64-slice spiral CT were enrolled in this study. The potential lymph node metastasis was evaluated by measuring or calculating the long diameter, extent of enhancement, and short-to-long diameter ratio of the lymph nodes. The results were compared with postoperative pathological findings.</p><p><b>RESULT</b>A long diameter ≥ 8mm,enhanced density ≥ 80Hu, and short-to-long diameter ratio ≥ 0.7 had the best consistency with postoperative pathological findings.</p><p><b>CONCLUSION</b>As a simple and noninvasive technique, multi-slice spiral CT is helpful to identify potential lymph node metastasis of gastric cancer based on long diameter, extent of enhancement, and short-to-long diameter ratio of the lymph nodes, and thus provide important information for surgery selection, prognosis, and development of new procedures.</p>