RESUMO
This article aimed to explore the theoretical connotation and mechanism of clearing damp-heat method in the treatment of chronic kidney disease (CKD), provide theoretical support for clearing damp-heat method in the treatment of chronic kidney disease, and further explain the modern scientific connotation of "damp-heat impairing kidney". Modern Traditional Chinese Medicine (TCM) believes that damp-heat is an important pathogenesis of kidney damage. Clearing damp-heat method plays a key role in inhibiting CKD immune inflammatory response, improving oxidative stress and antagonizing renal fibrosis. The mechanism is mainly related to the regulation of TNF-α level, blocking NF-κB signaling pathway, inhibiting inflammatory cytokines, antagonizing TGF-β1 secretion and other pathways.
RESUMO
Water pollution is a critical issue of global importance. Water environment modeling is an important tool for studying water pollution in basins. Based on a review of existing water environment models, a dynamic bidirectional coupling model for the water environment (E-DBCM), consisting of an upland watershed module (UWSM) and a 2D downstream waterbody module (DWBM), was developed using the multi-grid technique. The computational domain was discretized with grids of different sizes, and different time steps were adopted in regions with different grid sizes. The UWSM was applied to describe the generation and transport of pollutants on coarse grids to improve the computational efficiency, while the DWBM was capable of simulating the hydrodynamic and pollutant transport processes on fine grids to obtain a high accuracy. These two modules were spatially connected by a moving coupling boundary. Two test cases were used to validate the performance of the proposed model, and the results indicated that the E-DBCM had satisfactory computing efficiency while maintaining acceptable numerical accuracy. The water environment of the Yanqi River Basin was evaluated using the proposed E-DBCM. The maximum percent bias was 10.31 %, which indicates that the E-DBCM is reliable and that the numerical accuracy satisfies the engineering demand. The computational efficiency dramatically increased by 90 % when the watershed was discretized using the multi-grid technique. It was found that water pollution problems in this basin were serious, especially during the flood season. Various measures should be taken to improve the water environment treatment and strengthen protection measures in the Yanqi River Basin.
Assuntos
Monitoramento Ambiental , Poluição da Água , Simulação por Computador , Monitoramento Ambiental/métodos , Rios , Água , Poluição da Água/análiseRESUMO
Theory of Shen-Xu Pang-Guang-Re (SXPGR) is an important part of the theory of zang-fu in traditional Chinese medicine (TCM). And it is the generalization for etiology and pathogenesis of Lin-Zheng (LZ). In immunology, mucosal immune system is composed of mucosal-associated lymphoid tissues and immune cells, which can resist the invasion of microorganisms. Mucosal immune plays an important role in the occurrence of urinary tract infection. This paper, which was based on SIgA and homing mechanism, was to investigate the relevance between mucosal immunity and the theory of SXPGR, in order to study the connotation of SXPGR in TCM.
