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Objective To explore the epidemiological characteristics of 45 year-old or older human immunodeficiency virus (HIV)-infected persons and patients with acquired immune deficiency syndrome (AIDS) in Chengdu. Methods Epidemiological methods were used to analyze the data of 45 year-old or older patients with HIV/AIDS reported in Chengdu from 2018 to 2020. Results From 2018 to 2020, there were 219 newly reported cases aged 45 and above (35.67%) with HIV/AIDS in Chengdu, and the differences among them were statistically significant (χ2=6.45, P2=0.29, 0.22, 5.65, 1.92, 5.68, 1.12, 2.12, 0.39, P>0.05). 75.34% of the patients were infected through heterosexual transmission, and 50.68% were detected at treatment. The proportion of patients whose first CD4 cell test result was lower than 200/μL was relatively higher (43.84%). Nearly 81.28% of the patients received antiviral therapy, and the mortality reached 16.89%. From 2018 to 2020, the difference in transmission route, sample source, the first examination results of CD4 cells, antiviral treatment, or prognosis was not statistically significant (χ2=1.29, 3.59, 1.56, 0.01, 0.35, P>0.05). Fever (62.10%), fatigue (42.01%), and lymph node enlargement (28.77%) were main symptoms of the patients. 51.14% were detected in outpatient examinations, and most patients were accompanied by at least one opportunistic infection. Cytomegalovirus infection (56.16%) and Mycobacterium tuberculosis infection (36.53%) were main virus infection types. From 2018 to 2020, there was no significant difference in symptoms, visiting departments or combined infection (χ2=0.07-3.00, 3.00, 0.20-2.61, P>0.05). Conclusion The prevalence of HIV/AIDS is relatively severe in 45 year-old or older people in Chengdu. The constituent ratio and the incidence rate show an upward trend. Therefore, individualized prevention and control strategies should be formulated for 45 year-old or older people to effectively suppress the transmission of HIV/AIDS in the middle-aged and the elderly.
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<p><b>OBJECTIVE</b>To compare the differences of the efficacy and adverse reaction of Oxaliplatin (L-OHP) treatment to oral squamous cell carcinoma (OSCC) at four different daily time points, and to analyze the characteristics of circadian rhythms.</p><p><b>METHODS</b>Seventy-five nude mice were placed under 12h light and 12h dark cycles. Human OSCC cell line BcaCD885 was inoculated on the cheek of nude mice to establish a nude mice model of OSCC. After 3 weeks, mice were divided into 5 groups (4 experimental groups and 1 control group), with 15 in each group. L-OHP (17 mg x kg(-1)) was injected intravenously at 4 different time points during a period of 24 h, including 4 hours after lights on JHALO), 10 HALO, 16 HALO and 22 HALO for 4 experimental groups. The control group received normal saline of the same volume as that of L-OHP. The efficacy (tumor inhibition rate and survival time) and adverse reaction (body weight, white blood cell and perianal swelling) were observed after administration. The circadian rhythms of the efficacy and adverse reaction were examined by cosine analysis.</p><p><b>RESULTS</b>L-OHP injected at 4, 16 and 22 HALO had great tumor inhibition rates, however, only 16 and 22 HALO groups significantly prolonged survival time of mice. The adverse reactions at 4 and 10 HALO were significantly severer than that of 16 and 22 HALO. Cosine analysis showed survival time, body weight and white blood cell counts had significant circadian rhythms. Mice received L-OHP at 14.88 HALO had the longest survival time.</p><p><b>CONCLUSION</b>The time factor should be considered in L-OHP chronchemotherapy of patients with OSCC in order to increase the efficacy, decrease the adverse reaction of the drug and to improve the life quality of patients with OSCC.</p>
