Clinical study on continuous oral dosing of etopside combined with prednisone in the treatment of elderly patients with unspecific peripheral T-cell lymphoma / 白血病·淋巴瘤

Objective To investigate the efficacy and toxicity of etoposide combined with prednisone (EtoP regimen) for elderly patients with unspecific peripheral T-cell lymphoma (PTCL-U) compared with the CHOP regimen.Methods 23 elderly PTCL-U patients were randomly assigned to EtoP group (n =12) or CHOP group (n =11).The curative effects and the adverse reactions were analyzed and compared between the two groups by Log-rank test and x2 test.Results The overall response (OR) rate was 66.67 ％ (8/12) in EtoP group and 63.64 ％ (7/11) in CHOP group.There was no statistically significant difference between the two groups(x2 =0.023,P =0.879).The progression-free survival (PFS) was 7.55 months in EtoP group and 4.38 months in CHOP group,statistically significant difference were observed between the two groups (x2 =23.000,P =0.011).The overall survival (OS) was 15.02 months in EtoP group and 12.26 months in CHOP group,no statistically significant difference was observed between the two groups (x 2 =14.985,P =0.597).The main side effects were bone marrow depression and digestive tract toxicity,no hematology toxicity and digestive tract toxicity of grade Ⅲ-Ⅳ occurred in EtoP group.Of those in CHOP group were 36.36 ％ and 27.27 ％.Conclusion For elderly PTCL-U patients,EtoP regimen is an effective and well tolerated therapeutic schedule.

Injection safety assessments in two Chinese provinces, 2001-2009: progress and remaining challenges.

In 2009, an assessment of injection practices in Fumeng County (Liaoning Province) and Wulong County (Chongqing Municipality) (random sample of 29 hospitals, 40 village clinics and 400 villagers) was conducted and the results were compared with a prior 2001 assessment (same area, same WHO assessment tool). In 2009, all facilities in Fumeng and Wulong used new, disposable syringes compared with 34% in both counties in 2001. Moreover, 59% (95% CI 37-80%) and 74% (95% CI 55-94%) of providers in Fumeng and Wulong, respectively, collected used sharps safely compared with 33% (95% CI 20-45%) and 36% (95% CI 20-53%) in 2001. In Fumeng and Wulong, respectively, 5% (95% CI 0-15%) and 50% (95% CI 25-76%) of facilities discarded injection devices in the regular trash compared with 7% (95% CI 2-12%) and 64% (95% CI 47-80%) in 2001. Between 2001 and 2009, the annual average number of injections per person increased from 1.8 to 6.3 (95% CI 4.5-8.1) in Fumeng and was stable [3.4 and 3.1 (95% CI 1.9-4.3)] in Wulong. Overall, between 2001 and 2009, sterilisable injection devices disappeared and disposal practices improved. However, unsafe practices persisted, which should be improved. Use of injections to administer medications may be increasing and must be reduced.

Complications and prevention for the peri-operative period of 565 hepatic cancer arterial chemotherapy embolism / 中国基层医药

Objective To explore the complications and prevention for the peri-operative period of hepatic cancer arterial chemotherapy embolism (TACE). Methods 565 hepatic cancer sufferers' medical record through TACE therapy were analyzed retrospectively. Results The complications could be divided into three types according to complications genesic date:during the puncture and intubation,23 local hematomas, 14 arterial intima damnification; during the TACE operation period, 112 bellyache,242 spew,3 chough; after the TACE operation, 528 fever, 264 bellyache ,3 liver abscess,2 hepatorenal complication. The research results indicated that the most complications could be cured or lightened. Only 5 sufferers died within two weeks. Conclusion There were many kinds of complications during TACE operations, and the sufferers could get well and the complications could be effectively reduced if the nurse got along abortively during the whole operation.

?-Synuclein phosphorylation takes part in mouse dopaminergic neuron protection / 基础医学与临床

Objective To study the role of phosphorylation at Serine 129 in regulating the neurotoxicity of ?-synuclein. Methods Wild type and phosphomimic mutant ?-synuclein genes were over-expressed in mouse dopaminergic cells MN9D using retrovirus. The cell viability was examined using CCK-8 assay and cell morphology was observed by immunofluorescence microscopy. Results The result of real time PCR showed that WT/?-SYN and S129D/?-SYN genes were overexpressed in MN9D as compared to uninfected MN9D and vector control group(P