RESUMO
Types and mechanisms of drug - food interactions are described. The most frequently encountered interaction is of the pharmacokinetic type, by which food components change the absorption of drugs from the gastrointestinal tract and affect the biotransformation of drugs. The majority of such interactions is of cli- nical significance and must be taken into account in recommendations concerning methods of drug administration.
Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia , Interações Alimento-Droga , Preparações Farmacêuticas/administração & dosagem , Preparações Farmacêuticas/metabolismo , Farmacocinética , Biotransformação , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/metabolismo , Humanos , Absorção IntestinalRESUMO
We studied the effect of cannabinoid receptor agonists anandamide and WIN 55,212-2 on the central pain syndrome induced by intraspinal injection of penicillin sodium salt in rats. Cannabinoids suppressed allodynia and spontaneous attacks in rats with the central pain syndrome. The analgesic effect was most pronounced after intrathecal injection of cannabinoid receptor agonist in a dose of 100 microg in 10 microl. After systemic treatment the analgesic effect was produced by only WIN 55,212-2 in a dose of 1 mg/kg. WIN 55,212-2 was superior to anandamide by the duration and intensity of the effect on allodynia and spontaneous attacks.
