[Effect of thyroid and adrenal hormones on the course of hypervitaminosis A and D]. / Vliianie gormonov shchitovidnoi zhelezy i nadpochechnikov na techenie gipervitaminozov A i D.

Tests staged on normal and hypophysectomized rats demonstrated thyroxin to potentiate the general toxic effect of ergocalciferol, with final death of the animals. At the same time, the blood calcium content in animals receiving thyroxin decreases under the effect of the latter. Hydrocortisone, while producing no effect on the high calcium content in the blood of the animals receiving ergocalciferol, attenuates the general toxic action of the latter. These data point to the possibility of dissociating the general toxic action of ergocalciferol and its influence on the blood calcium level, which disproves the existing notion on the correlation between general toxic action of ergocalciferol and hypercalcemia produced by it. Thyroxin and hydrocortisone do not have any effect on the nature of the action exerted by high doses of vitamin A.

[Effect of thyroxine and hydrocortisone on the content of retinol and retinyl palmitate in liver tissue, kidney and blood of rats, loaded with high doses of retinyl acetate]. / Vliianie tiroksina i gidrokortizona na coderzhania retinola i retinilpal'mitata v peeheni, pochkakh i krovi krys, poluchayshikh vysokie dozy retinilatsetatata.

Administration of hight doses of retinyl acetate into rats caused an increase in content of retinol in liver tissue and kidney and retinyl palmitate in liver tissue, kidney and blood. The simultaneous administration of thyroxine decreased the accumulation of retinol and retinyl palmitate in liver tissue. At the same time, in kidney content of retinol was increased but content of retinol and retinyl palmitate in blood and retinyl palmitate in kidney did not differ from the values estimated in the control group. The simultaneous administration of retinyl acetate and hydrocortisone decreased the accumulation of retinol and retinyl palmitate in liver tissue, increased the content of vitamin A in blood and did not influence its content in kidney.