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J Biol Regul Homeost Agents ; 22(4): 247-52, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-19036227

RESUMO

Hyaluronic Acid (HA) is an alternative method for the treatment of osteoarthritis (OA), which acts on pain through a double action: anti-inflammatory and synovial fluid (SF) visco-supplementation. Magnetic Resonance Imaging (MRI), utilizing specific sequences, is a valid method for studying the initial phase of chondral damage. The analysis of the data, obtained through the intensity of values taken by positioning Region of Interest (ROIs) within the lesion, determining the differences before and after treatment with HA injected into the knee. The results obtained after six months and one year from the injection were statistically different in respect to those taken before, immediately and after three months of treatment. MRI represents a valid tool to evaluate the grade of chondromalacia patellae and also to follow the cartilage modification induced by HA therapy.


Assuntos
Condromalacia da Patela/tratamento farmacológico , Ácido Hialurônico/uso terapêutico , Viscossuplementos/uso terapêutico , Adolescente , Adulto , Condromalacia da Patela/patologia , Condromalacia da Patela/fisiopatologia , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Qualidade de Vida , Fatores de Tempo , Adulto Jovem
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