1.
Chem Commun (Camb)
; 59(49): 7655-7658, 2023 Jun 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37259939
RESUMO
In this manuscript, the application of pentaenolate intermediates in the allylic alkylation of indene-2-carbaldehydes with Morita-Baylis-Hillman (MBH) carbonates is described. The reaction has been carried out in a highly enantio- and diastereoselective manner due to the use of a chiral tertiary amine as a nucleophilic catalyst. The developed reactivity constitutes the first application of organocatalytic pentaenolate activation in asymmetric synthesis, expanding the arsenal of catalytic methods.