1.
Pharmazie
; 52(7): 567-9, 1997 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9266598
Assuntos
Antineoplásicos/uso terapêutico , Leucemia L1210/tratamento farmacológico , Leucemia P388/tratamento farmacológico , Animais , Antineoplásicos/efeitos adversos , Leucemia L1210/patologia , Leucemia P388/patologia , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos DBA , Transplante de Neoplasias
2.
Farmaco
; 52(12): 751-3, 1997 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9648281
RESUMO
We synthetized pyridobenzoxazocynone that differs in the enlarged eight-membered heterocyclic system from the basic structure of pyridobenzoxazepinones a known class of non-nucleoside HIV-1 reverse transcriptase inhibitors. Pyridobenzoxazocynone hydrochloride was found to inhibit HIV-1 reverse transcriptase activity. At concentration 0.35 microM the enzyme activity decreased by 64 +/- 14%. Higher concentrations of pyridobenzoxazocynone hydrochloride completely abolished the enzyme activity expressed as radioactivity of acid insoluble products. These results suggest that pyridobenzoxazocynones may represent a new class of HIV-1 reverse transcriptase inhibitors.
Assuntos
Transcriptase Reversa do HIV/antagonistas & inibidores , Oxazocinas/síntese química , Piridinas/síntese química , Inibidores da Transcriptase Reversa/síntese química , Produtos do Gene pol/antagonistas & inibidores , Humanos , Estrutura Molecular , Oxazocinas/farmacologia , Piridinas/farmacologia , Inibidores da Transcriptase Reversa/farmacologia
3.
Acta Pol Pharm
; 52(3): 241-4, 1995.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8960255