Assuntos
Deficiência de Vitaminas/diagnóstico , Vitaminas/sangue , Ácido Ascórbico/sangue , Deficiência de Vitaminas/complicações , Deficiência de Vitaminas/epidemiologia , Ensaios Enzimáticos Clínicos , Diabetes Mellitus/metabolismo , Feminino , Gastroenteropatias/metabolismo , Hospitalização , Humanos , Hepatopatias/metabolismo , Masculino , Piridoxina/sangue , Riboflavina/sangue , Tiamina/sangueRESUMO
In twenty control subjects, twenty diabetic patients without macro-angiopathy and forty diabetic patients with an acute and severe arteriopathy of lower limbs, we studied the red cell filterability (TFE) on total blood, the 2-3 diphosphoglycerate level (2-3 DPG) and the Adenosine Triphosphate level (ATP). The diabetic's impairement of the red cell filterability and ATP level are all the more important than the subject is suffering from an acute arteriopathy of lower limbs. For the same subjects, we notice that the 2-3 DPG level increases significantly. The filterability is related to the ATP red cell concentration. An ATP depletion produces an increase membrane rigidity and a minor filterability. These findings strongly suggest a relation that can exist between the red cell metabolic state and filterability in diabetic population with or without macroangiopathy.
Assuntos
Diabetes Mellitus/sangue , Membrana Eritrocítica/metabolismo , Eritrócitos/metabolismo , Filtros Microporos , Doenças Vasculares/sangue , 2,3-Difosfoglicerato , Trifosfato de Adenosina/biossíntese , Adulto , Artérias/patologia , Complicações do Diabetes , Ácidos Difosfoglicéricos/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Vasculares/complicaçõesRESUMO
The diabetic's impairment of the red cell filterability is all the more important if the diabetic subject is suffering from an acute and progressive lower limb arteriopathy. Red cell 2-3 diphosphoglycerate (2-3 DPG) increases when red cell filterability decreases among these patients. Pentoxifylline (i.v. 600 mg per day) produces a rapid initial improvement of red cell filterability and then increases red cell 2-3 DPG level.
