RESUMO
BACKGROUND: Women that carry germ-line mutations for BRCA1 or BRCA2 genes are at an increased risk of developing breast, ovarian and peritoneal cancer. Primary peritoneal carcinoma is a rare tumour histologically identical to papillary serous ovarian carcinoma. Risk-reducing surgery in the form of mastectomy and oophorectomy in premenopausal women has been recommended to prevent breast and ovarian cancer occurrence and decrease the risk of developing primary peritoneal cancer. CASE PRESENTATION: We present a case report of a woman with a strong family history of breast cancer who underwent risk-reducing surgery in the form of bilateral salpingo-oophorectomy following a mastectomy for a right-sided breast tumour. Following the finding of a BRCA1 mutation, a prophylactic left-sided mastectomy was performed. After remaining well for twenty-seven years, she presented with rectal bleeding and altered bowel habit, and was found to have a secondary cancer of the sigmoid colon. She was finally diagnosed with primary papillary serous carcinoma of the peritoneum (PSCP). CONCLUSION: PSCP can present many years after risk-reducing surgery and be difficult to detect. Surveillance remains the best course of management for patients with known BRCA mutations.
Assuntos
Adenocarcinoma/genética , Adenocarcinoma/secundário , Neoplasias da Mama/genética , Cistadenocarcinoma Seroso/patologia , Genes BRCA1 , Segunda Neoplasia Primária/patologia , Neoplasias Peritoneais/patologia , Neoplasias do Colo Sigmoide/secundário , Adenocarcinoma/cirurgia , Adulto , Neoplasias da Mama/patologia , Neoplasias da Mama/cirurgia , Colectomia/métodos , Cistadenocarcinoma Seroso/cirurgia , Diagnóstico Diferencial , Feminino , Seguimentos , Predisposição Genética para Doença , Humanos , Mastectomia/métodos , Mutação , Neoplasias Ovarianas/patologia , Neoplasias Ovarianas/prevenção & controle , Neoplasias Ovarianas/cirurgia , Ovariectomia , Neoplasias Peritoneais/secundário , Neoplasias Peritoneais/cirurgia , Prevenção Primária/métodos , Medição de Risco , Neoplasias do Colo Sigmoide/cirurgia , Fatores de Tempo , Resultado do TratamentoRESUMO
Soy peptides were characterized for flavor, chemical properties, and hydrophobicity to investigate their relationships with bitterness. Five peptide fractions ranging in average molecular mass from 580 to 11300 Da were fractionated by ultrafiltration from two commercial soy protein hydrolysates. The bitterness of fractionated peptides was related to molecular mass, with maximum bitterness observed at approximately 4000 Da for one hydrolysate and 2000 Da for the other. The bitterness increased as the peptide M(w) decreased to 3000 Da for the first hydrolysate and to 2000 Da for the second one and then decreased as the peptide M(w) decreased below 1000 Da. The peptide fraction with molecular mass of <1000 Da showed the lowest bitterness for both. The hydrophobicity data based on Q values do not support Ney's Q rule as a predictor of bitterness for soy peptides.
