The Tulving-Wiseman law and the recognition of recallable music.

Memory for well-known musical phrases was tested first for recognition in the absence of any specific musical context and then for recall given the preceding musical phrase as a contextual cue. Recognition and recall were found to be largely, but not completely, independent. Moreover, there was no evidence of any greater dependency between recognition and recall than that previously observed in the relation between word recognition and recall, as summarized by the Tulving-Wiseman law. These findings significantly extend the range of applicability of this law.

The perception of expressive timing in music.

This paper is concerned with the perception of small-scale timing changes in musical sequences. The control and expressive function of these have been studied quite extensively from a production perspective, but not much is known about listeners' ability to detect them. A pilot study and two experiments are reported which investigate the detectability of different amounts of timing change in different sequential positions, different pitch contexts, and against the background of both metronomic and expressive comparisons. The results show that listeners are able to perceive as little as 20 ms lengthening in the context of notes lasting between 100 and 400 ms, and that this threshold appears not to be a function of base duration in this range. Sequential position and pitch structure influence the detectability of timing changes to a limited extent, for which some possible explanations are offered. A case is made for regarding timing in music as both a medium to convey structure and an object in its own right, suggesting that it may be perceptually organized in two different ways--as the consequence of a structural interpretation and as a directly registered quantity.

Free amino acid levels in the blood of patients undergoing parenteral alimentation.

Free amino acid levels were determined in the blood of patients undergoing parenteral alimentation. During amino acid infusions, alanine, valine, glycine, isoleucine, leucine, proline, threonine, serine, methionine, phenylalanine, and lysine levels increased. Bivariate regression analysis was then done to determine the average rise in each amino acid when 1 mmole/hr of that amino acid was infused and when 1 mmole/hr of glucose was infused. This analysis was done on both arterial plasma and arterial wh-le blood increments. The average rise in the amino acid level with 1 mmole of infusion per hour varied from 32 to 133 mumole/liter. Only alanine levels were positively correlated with glucose infusion, while the branched chain levels were all negatively correlated. In no instance could a significant positive arteriovenous difference across the forearm be correlated with the infusion of an amino acid, despite amino acid levels as much as five times normal. Methionine, proline, valine, threonine, and lysine showed the greatest rise in blood concentration per millimole of amino acid infused per hour suggesting that their degradation or use in protein synthesis was limited. While the blood concentration rise in glycine was only about half as much per millimole per hour infused as was found in the previously mentioned group of amino acids, high rates of infusion of this amino acid resulted in large increments inglycine levels. It may be desirable to reduce the amounts of these amino acids in parenteral amino acid formulations.

Lactic acidosis and liver disease.

Both acute and chronic hepatic insufficiency can result in lactate accumulation and lactic acidosis; data from both types of patients were compared. In the chronic group, an acute precipitating event was identified in seven of nine subjects. Four had sepsis and three had gastrointestinal hemorrhage. In these patients, results from most tests of hepatic function were not altered dramatically. There were no long-term survivors in this group. In contrast, patients with acute hepatic failure had striking alterations in their results of hepatic function tests. Notable prolongation of the prothrombin time was always present initially and antedated other abnormalities of hepatic function. Three of seven patients in this group survived. Hypoglycemia was seen in both groups and in two subjects with acute hepatic insufficiency, glucose administration alone resulted in rapid lowering of lactate levels.

Peripheral amino acid levels in patients with cancer.

Peripheral arterial and venous whole blood amino acid concentrations were determined in four groups of subjects after an overnight fast 1) normal people, 2) patients with cancer who had not lost body weight, 3) subjects with cancer who had lost more than 20% of body weight and 4) patients who had lost more than 20% of body weight from diminished intake due to cause other than cancer. Comparison of the arterial blood levels in the four groups showed that patients with cancer and weight loss had amino acid patterns different from patients who were malnourished for other reasons. Branched chain amino acids were normal in patients with malignant disease. Some gluconeogenic amino acids were reduced as in other subjects with weight loss but the characteristic rise in glycine seen with malnutrition was not present. Arterio venous differences in whole blood across the forearm showed no evidence of increase in venous excess in patients with progressive malignant disease, indicating no excessive protein catabolism in muscle tissue. The data are consistent with increased gluconeogenesis in malnourished cancer subjects, probably due to intrinsic change in hepatic metabolism.