Assuntos
Fármacos Anti-HIV/efeitos adversos , Infecções por HIV/tratamento farmacológico , Lamivudina/efeitos adversos , Lipodistrofia/induzido quimicamente , Inibidores da Transcriptase Reversa/efeitos adversos , Estavudina/efeitos adversos , Fármacos Anti-HIV/uso terapêutico , Quimioterapia Combinada , Feminino , Humanos , Lamivudina/uso terapêutico , Pessoa de Meia-Idade , Inibidores da Transcriptase Reversa/uso terapêutico , Estavudina/uso terapêuticoRESUMO
CASE REPORTS: Two cases of linear and whorled nevoid hypermelanosis are reported. Cutaneous lesions (hyperpigmented macules along Blaschko's lines) appeared gradually after birth. Neurologic anomalies were detected in both cases (symptomatic in one, only cerebral MRI anomalies in the other). CONCLUSION: This sporadic condition, probably caused by somatic mosaicism, must be differentiated from incontinentia pigmenti, Mac Cune-Albright disease and chimerism. Its situation among the Blaschko linear pigmentary anomalies (hypomelanosis of Ito) is discussed.
Assuntos
Melanose/patologia , Nevo/patologia , Neoplasias Cutâneas/patologia , Pele/patologia , Encéfalo/patologia , Criança , Feminino , Humanos , Lactente , Imageamento por Ressonância Magnética , Masculino , Malformações do Sistema Nervoso/patologiaRESUMO
BACKGROUND: Rouget du porc, or swine erysipelas, usually occurs in man as Rosenbach's erysipeloid. Septicemic forms are more uncommon and can be associated with dermal involvement far from the site of inoculation. We report a case in a patient given corticosteroid therapy for systematic lupus. CASE REPORT: A 50-year-old farmer was seen with fever, infiltrative erythema of the long finger and dorsal lesions on the ring finger which developed after a skin lesions caused by a duck. The diagnosis of septicemic rouget du porc was made after isolating the germ from blood cultures. There was no associated endocarditis. Fever and skin lesions totally regressed after treatment with ceftriaxone. DISCUSSION: The diagnosis of erysipeloid was supported by epidemiologic arguments and characteristic clinical features. The corticosteroid therapy was probably a favoring factor for development of septicemia. Positive diagnosis is usually obtained from blood culture but the germ can be isolated from skin biopsies at the site of inoculation. Our patient was free of endocarditis which should always be suspected. Endocarditis is frequent and often fatal. Intravenous high-dose penicillin G is recommanded treatment.
Assuntos
Bacteriemia/diagnóstico , Mordeduras e Picadas/complicações , Patos , Erisipeloide/diagnóstico , Dermatopatias Infecciosas/diagnóstico , Animais , Bacteriemia/tratamento farmacológico , Bacteriemia/etiologia , Ceftriaxona/uso terapêutico , Cefalosporinas/uso terapêutico , Erisipeloide/tratamento farmacológico , Erisipeloide/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Dermatopatias Infecciosas/tratamento farmacológico , Dermatopatias Infecciosas/etiologiaRESUMO
The authors report a case of malignant breast tumour induced by oestrogens in a patient treated for 7 years for carcinoma of the prostate. They review the literature on the subject and stress the important diagnostic and prognostic role of hormonal receptor assays. These allow the much more numerous cases of mammary metastases of prostatic cancer to be distinguished and, in cases of primary malignant tumour, they permit the choice of the best possible hormone therapy available.
Assuntos
Adenocarcinoma/induzido quimicamente , Neoplasias da Mama/induzido quimicamente , Estrogênios/efeitos adversos , Neoplasias da Próstata/tratamento farmacológico , Adenocarcinoma/tratamento farmacológico , Adenocarcinoma/secundário , Idoso , Neoplasias da Mama/secundário , Humanos , Masculino , Neoplasias Hormônio-Dependentes/induzido quimicamente , Prognóstico , Receptores de Estrogênio/análiseRESUMO
Thymosine fraction V was shown to exert a stimulation activity on T lymphocytes from Papio papio, as determined by E. Rosette and active E. Rosette formation. Testosterone inhibited this effect of thymosin.