Tratamiento del dolor en pancreatitis crónica calcificante con endoscopía y ondas de choque extracorpóreas. A propósito de un caso / Treatment of pain in chronic calcification pancreatitis with endoscopy and extracorporeal shock wave lithotripsy. Presentation of a case

Abdominal pain is the most frequent symptom of chronic pancreatitis and may, on occasions, lead to great treatment problems. The case of a 56-years-old patient with idiopathic chronic pancreatitis calcifying who showed intracanalicular lithiasis is reported. Treatment with endoscopy and extracorporal shock wave lithotripsy (ESWL) was successful. (Au)

Tratamiento del dolor en pancreatitis crónica calcificante con endoscopía y ondas de choque extracorpóreas. A propósito de un caso / Treatment of pain in chronic calcification pancreatitis with endoscopy and extracorporeal shock wave lithotripsy. Presentation of a case

Abdominal pain is the most frequent symptom of chronic pancreatitis and may, on occasions, lead to great treatment problems. The case of a 56-years-old patient with idiopathic chronic pancreatitis calcifying who showed intracanalicular lithiasis is reported. Treatment with endoscopy and extracorporal shock wave lithotripsy (ESWL) was successful.

[Treatment of pain in chronic calcifying pancreatitis with endoscopy and extracorporeal shock wave lithotripsy. A case report]. / Tratamiento del dolor en pancreatitis crónica calcificante con endoscopía y ondas de choque extracorpóreas. A propósito de un caso.

Abdominal pain is the most frequent symptom of chronic pancreatitis and may, on occasions, lead to great treatment problems. The case of a 56-years-old patient with idiopathic chronic pancreatitis calcifying who showed intracanalicular lithiasis is reported. Treatment with endoscopy and extracorporal shock wave lithotripsy (ESWL) was successful.

Tratamiento del dolor en pancreatitis crónica calcificante con endoscopía y ondas de choque extracorpóreas. A propósito de un caso. / [Treatment of pain in chronic calcifying pancreatitis with endoscopy and extracorporeal shock wave lithotripsy. A case report]

Abdominal pain is the most frequent symptom of chronic pancreatitis and may, on occasions, lead to great treatment problems. The case of a 56-years-old patient with idiopathic chronic pancreatitis calcifying who showed intracanalicular lithiasis is reported. Treatment with endoscopy and extracorporal shock wave lithotripsy (ESWL) was successful.

Blockade of tolerance to stress-induced analgesia by MK-801 in mice.

The N-methyl-D-aspartate (NMDA) receptor has been implicated in mechanisms of tolerance to morphine-induced analgesia. The present study examined the role of the NMDA receptor in the development of tolerance to stress-induced analgesia (SIA). In the first experiment, mice were exposed to a stressor (a 3-min forced swim in water maintained at 32 degrees C) once daily for 15 consecutive days. Analgesia was measured 2 min after stress on the first and last day using the hot-plate test. To examine the role of the NMDA receptor in the development of tolerance to SIA mice were treated daily with the non-competitive NMDA receptor antagonist, MK-801, 15 min before swimming. Pretreatment with MK-801 was found to block both analgesia and tolerance. In a second experiment, to examine whether SIA and tolerance to SIA are mediated by similar or different mechanisms, mice were injected daily with MK-801 after analgesia had dissipated (1 h following swim). Tolerance to SIA was blocked by delayed injections of MK-801. These results suggest that the NMDA receptor is involved in mechanisms of tolerance to SIA, independent of its role in analgesia.

[Pericarditis disclosing at adult age recurrent Still's disease in childhood]. / Péricardite révélatrice à l'âge adulte d'une récidive de maladie de Still de l'enfant.

A 29 year old patient with a history of juvenile rheumatoid arthritis had a recurrence 12 years later, presenting as pericardial effusion with cardiac tamponade. Cardiac tamponade is a rare complication of Still's disease. To the author's knowledge, it has never been described as the mode of presentation of adult Still's disease. The diagnostic difficulties and inefficacy of non-steroid anti-inflammatory agents are illustrated by this case.

[Pharmacokinetics of ofloxacin administered orally in elderly subjects with bronchial or urinary tract infections]. / Pharmacocinétique de l'ofloxacine administrée par voie orale chez le sujet âgé atteint d'infections bronchiques ou urinaires.

The pharmacokinetics of ofloxacin orally administered were investigated at the steady-state in sixteen elderly patients older than 65 years. Patients with either urinary tract of respiratory tract mild infectious were divided into two age-dependent groups A and B. Group A: eight patients (65-80 years) received 200 mg of ofloxacin by the oral route every 12 hours and group B: eight patients older than 80 years, received 200 mg of ofloxacin by the oral route every 24 hours. The pharmacokinetic study was performed on treatment day 5. Plasmatic levels and urinary excretion of ofloxacin during 12 or 24 hours were assayed by means of high pressure liquid chromatography. Wide variations in plasma ofloxacin concentrations were observed within each group (Cmax range, group A: 1.9-9.2 mg/l, group B: 1.6-10.0 mg/l). Similar variability was observed for ofloxacin elimination parameters (CI/F, renal CI(R)/F) and half-life. In contrast, within-group and between-group differences in the volume of distribution adjusted for weight were not significant (group A: 1.22 +/- 0.44 l.kg; group B: 1.49 +/- 0.53 l.kg), but these values were approximately half those observed in the young adult. Plasmatic [CI/F] and renal clearance [CI(R)/F] of ofloxacin were correlated with creatinine clearance in both groups and in the overall population studied. Then the overall population was classified in terms of creatinine clearance [group 1: greater than 50 ml/min; group 2: less than or equal to 50 (minimum 20) ml/min]. The pharmacokinetics of ofloxacin in the elderly are characterized by a decrease in the volume of distribution and in plasmatic and renal clearances.(ABSTRACT TRUNCATED AT 250 WORDS)

[A case of congenital non-spherocytic hemolytic anemia caused by enzyme deficiency in pyruvate kinase]. / A propos d'un cas d'anémie hémolytique congénitale non sphérocytaire par déficit enzymatique en pyruvate-kinase.

About a familial observation of PK deficiency, the authors emphasize the important clinical and biochemical heterogeneity. Interest of isotopic explorations in the therapeutic decision of splenectomy.