Analytical and Clinical Evaluation of the NOWDiagnostics ADEXUSDx Human Chorionic Gonadotropin Test Using Whole Blood.

BACKGROUND: Point-of-care (POC) urine qualitative human chorionic gonadotropin (hCG) devices are used to rapidly assess pregnancy status, but many of these devices are susceptible to false-negative results caused by increased concentrations of hCG ß core fragment (hCGßcf) that does not contain hCGßcf. METHODS: Purified hCG was added to hCG-negative heparinized whole blood to generate samples with known hCG concentrations, and the resulting samples were used to evaluate device sensitivity, low-end reproducibility, high-dose hook effect, intermediate range performance, acceptable sample volume, acceptable hematocrit range, and lot-to-lot variation. Device performance was also prospectively evaluated in 40 pregnant and 40 nonpregnant women aged 18-44 years in a hospital-based clinic or an academic hospital emergency department. RESULTS: All device observations were positive using a whole blood sample containing a plasma hCG concentration of 2.2 × 106 IU/L, and all device observations were positive from18 IU/L to 1.2 × 103 IU/L and from 2.5 × 104 IU/L to 2.2 × 106 IU/L. Three invalid results were observed in the intermediate range because of decreased control line intensity. The minimum sample volume was 30 µL, and maximum hematocrit was 46%. In 40 pregnant and 40 nonpregnant women aged 18-44 years, the device generated 100% concordance with urine qualitative and plasma quantitative test results. CONCLUSIONS: The ADEXUSDx™ hCG test demonstrates acceptable performance for the determination of pregnancy status using capillary fingerstick samples.

Whom do veteran nursing home residents prefer to talk to about satisfaction with care?: implications for nursing staff.

The purpose of this study was to determine whom residents in U.S. Department of Veterans Affairs (VA) nursing homes prefer to talk to about their quality of care. A total of 127 participants in three VA facilities completed a structured, in-person interview. Nearly half (47.6%) reported that they prefer talking with facility staff about their quality of care, with the most preferred staff being licensed nurses and physicians. However, 26% reported being hesitant to express complaints for fear of reprisal. Participants also reported being least comfortable talking to direct care staff (nurse aides) if they saw another resident being mistreated. These findings suggest that licensed nurses and primary care professionals, both of whom are in frequent contact with residents, should routinely ask residents questions about their quality of care so that nursing home residents have ample opportunity to express concerns. Finally, asking satisfaction questions routinely may also enable facilities to address problems as they occur.

Documentation and management of words associated with delirium among elderly patients in postacute care: a pilot investigation.

OBJECTIVE: To describe in a pilot investigation the frequency that keywords associated with delirium were documented by providers and to study the effect of reporting such observations on physician orders. DESIGN: Retrospective investigation. SETTINGS AND PARTICIPANTS: Eighty elderly patients identified from 895 admitted to 2 postacute care (PAC) facilities. MEASUREMENTS: Keywords associated with delirium were confusion, disorientation, altered mental status, delirium, agitation, inappropriate behavior, mental status change, inattention, hallucination, and lethargy. The source of the words and actions taken were recorded. RESULTS: Keywords associated with delirium were identified in 80 (9%) of 883 patients who met inclusion criteria, with the term "confusion" most frequently noted (95%). Nurses and physicians recorded keywords in 79 (99%) and 55 (69%) patient charts. The actual term "delirium" was used in only 6 (7%) of 80 cases. In 55 (69%) cases when physicians were notified, treatments or evaluations were performed: pharmacological 55 (100%), nonpharmacological 11 (20%), assessments 38 (69%), transfer to the emergency department 19 (34%). Nurses did not alert physicians in 25 (31%) cases where keywords were found and thus no action was taken in these cases. CONCLUSIONS: In this pilot investigation in the postacute setting, nurses and physicians documented words associated with delirium in 9% of the patient charts. When nurses notified physicians of patients with charted keywords suggesting delirium, physicians responded with orders for further assessments or pharmacological interventions. However, nurses did not refer patients with keywords in 1 of 3 cases and no actions were documented in the charts for these patients.

Resident complaints about the nursing home food service: relationship to cognitive status.

Most nursing home (NH) residents are not interviewed about their satisfaction with the food service due to cognitive impairment. The purpose of this study was to determine the proportion of NH residents able to complete a structured interview to assess food complaints when no cognitive status criteria were used to exclude residents from interview. Eighty-nine percent of 163 residents were able and willing to complete the interview, and 65% expressed complaints about the NH food service. Residents who expressed complaints ate less of their meals, had less cognitive impairment, and had more depressive symptoms than those who did not. This study shows that the majority of NH residents are able to reliably answer questions about their satisfaction with the food service, regardless of cognitive status, and the presence of complaints is related to poor meal intake and depressive symptoms.