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1.
BMC Public Health ; 22(1): 1453, 2022 07 30.
Artigo em Inglês | MEDLINE | ID: mdl-35908051

RESUMO

BACKGROUND: One in three women experience sexual violence during their lifetime; however, little is known about this phenomenon with respect to justice-involved Latina mothers. Using the reproductive justice framework as a theoretical lens, we examined sexual violence in Latina mothers who had experienced incarceration and were thus involved in the justice system. METHODS: This was a secondary analysis of a qualitative data set. The reproductive justice framework provided a theoretical lens for examining the women's rights to bodily autonomy, to have or not have children, and to live in safe, sustainable environments given the intersection of incarceration and sexual violence. RESULTS: Women (N = 12) recounted their experiences of sexual violence after having been incarcerated. Incarceration and resulting sexual violence led to discrimination, limited bodily autonomy, sexual exploitation, substance use, depression, anxiety, re-traumatization, recidivism, underreporting of violence, underutilization of healthcare resources, strained relationships, family separation, and unsafe environments. CONCLUSIONS: More research is needed to understand the social, economic, and political contexts that perpetuate sexual violence among justice-involved women. Universal healthcare, participatory research, changing cultural mindsets, decriminalization of sex work, and more comprehensive tracking and prosecution of sexual predators may be key to ending sexual violence in justice-involved mothers.


Assuntos
Delitos Sexuais , Criança , Feminino , Hispânico ou Latino , Humanos , Mães , Violência , Direitos da Mulher
2.
Nanotechnology ; 29(13): 134003, 2018 Apr 03.
Artigo em Inglês | MEDLINE | ID: mdl-29372887

RESUMO

Advanced memory technology based on carbon nanotubes (CNTs) (NRAM) possesses desired properties for implementation in a host of integrated systems due to demonstrated advantages of its operation including high speed (nanotubes can switch state in picoseconds), high endurance (over a trillion), and low power (with essential zero standby power). The applicable integrated systems for NRAM have markets that will see compound annual growth rates (CAGR) of over 62% between 2018 and 2023, with an embedded systems CAGR of 115% in 2018-2023 (http://bccresearch.com/pressroom/smc/bcc-research-predicts:-nram-(finally)-to-revolutionize-computer-memory). These opportunities are helping drive the realization of a shift from silicon-based to carbon-based (NRAM) memories. NRAM is a memory cell made up of an interlocking matrix of CNTs, either touching or slightly separated, leading to low or higher resistance states respectively. The small movement of atoms, as opposed to moving electrons for traditional silicon-based memories, renders NRAM with a more robust endurance and high temperature retention/operation which, along with high speed/low power, is expected to blossom in this memory technology to be a disruptive replacement for the current status quo of DRAM (dynamic RAM), SRAM (static RAM), and NAND flash memories.

3.
Arch Environ Contam Toxicol ; 50(4): 575-9, 2006 May.
Artigo em Inglês | MEDLINE | ID: mdl-16453067

RESUMO

The Hanford Nuclear Reservation in south central Washington was claimed by the federal government as a site for the production of plutonium. During the course of production and operation of the facilities at Hanford, radionuclides and chromium were discharged directly into the river and also contaminated the groundwater. This study was designed to assess the effects of chromium (Cr) on Chinook salmon (Oncorhynchus tshawytscha) fertilization under exposure conditions similar to those of the Hanford Reach of the Columbia River. Chinook salmon gametes were exposed to aqueous Cr concentrations ranging from 0 to 266 microg Cr l(-1). The current ambient water-quality criteria (AWQC) established for the protection of aquatic life (United States Environmental Protection Agency [USEPA] 1986) is 11 microg Cr l(-1). Cr has been measured in pore water from bottom sediments of the Columbia River at concentrations >600 microg Cr l(-1). Under exposure conditions designed to closely mimic events that occur in the river, the fertilization of Chinook salmon eggs was not affected by concentrations of Cr ranging from 11 to 266 microg Cr l(-1). Data suggest that the instantaneous nature of fertilization likely limits the potential effects of Cr on fertilization success. As a result, the current AWQC of 11 mug Cr l(-1) is most likely protective of Chinook salmon fertilization.


Assuntos
Cromo/toxicidade , Fertilização/efeitos dos fármacos , Rios , Salmão/crescimento & desenvolvimento , Poluentes Químicos da Água/toxicidade , Animais , Cromo/análise , Masculino , Rios/química , Testes de Toxicidade , Washington , Poluentes Químicos da Água/análise
4.
Appl Microbiol Biotechnol ; 59(6): 737-45, 2002 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-12226734

RESUMO

An organism, identified as Mycobacterium phlei GTIS10, was isolated based on its ability to use dibenzothiophene (DBT) as a sole source of sulfur for growth at 30-52 degrees C. Similar to other biodesulfurization-competent organisms, M. phlei GTIS10 converts DBT to 2-hydroxybiphenyl (2-HBP), as detected by HPLC. The specific desulfurization activity of the 50 degrees C M. phlei GTIS10 culture was determined to be 1.1+/-0.07 micromol 2-HBP min(-1) (g dry cell)(-1). M. phlei GTIS10 can also utilize benzothiophene and thiophene as sulfur sources for growth. The dszABC operon of M. phlei GTIS10 was cloned and sequenced and was found to be identical to that of Rhodococcus erythropolis IGTS8. The presence of the R. erythropolis IGTS8 120-kb plasmid pSOX, which encodes the dszABC operon, has been demonstrated in M. phlei GTIS10. Even though identical dsz genes are contained in both cultures, the temperature at which resting cells of R. erythropolisIGTS8 reach the highest rate of DBT metabolism is near 30 degrees C whereas the temperature that shows the highest activity in resting cell cultures of M. phlei GTIS10 is near 50 degrees C, and activity is detectable at temperatures as high as 57 degrees C. In M. phlei GTIS10, the rate-limiting step in vivo appears to be the conversion of DBT to dibenzothiophene sulfone catalyzed by the product of the dszC gene, DBT monooxygenase. The thermostability of individual desulfurization enzymes was determined and 2-hydroxybiphenyl-2-sulfinate sulfinolyase, encoded by dszB, was found to be the most thermolabile. These results demonstrate that the thermostability of individual enzymes determined in vitro is not necessarily a good predictor of the functional temperature range of enzymes in vivo.


Assuntos
DNA Bacteriano/genética , Mycobacterium/isolamento & purificação , Tiofenos/metabolismo , DNA Bacteriano/química , Temperatura Alta , Mycobacterium/genética , Mycobacterium/metabolismo , Oxirredutases/química , Oxirredutases/genética , Oxigenases/química , Oxigenases/genética , Reação em Cadeia da Polimerase , Análise de Sequência de DNA
5.
Holist Nurs Pract ; 15(3): 45-55, 2001 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-12120111

RESUMO

The purpose of this phenomenological study was to discover, describe, and understand the lived experience of some of Maine's most isolated elder women, those living alone on islands off the coast. Nine women, age 80 and older, were interviewed. Three dominant themes essential to this rural island lifeway emerged: no one is an island, no one lives alone; securely anchored in safe harbor; and weathering the storms. Results were that these women remain actively engaged in life, feeling valued and connected, safe and secure; they are resourceful, resilient, and determined.


Assuntos
Adaptação Psicológica , Idoso/psicologia , Relações Interpessoais , Saúde da Mulher , Mulheres/psicologia , Atividades Cotidianas , Idoso de 80 Anos ou mais , Feminino , Humanos , Maine , Pesquisa Metodológica em Enfermagem , Qualidade de Vida , Inquéritos e Questionários
6.
Am J Ment Retard ; 105(4): 236-51, 2000 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10934566

RESUMO

A variety of behavioral and emotional problems have been associated with attention deficit disorder with hyperactivity (ADHD) in children of average intellect. In contrast, little is known about concomitant behavioral and emotional problems in children with ADHD and mental retardation. In this study, we used the Personality Inventory for Children-Revised to assess the behavioral adjustment of 48 children with mental retardation and ADHD compared to that of 47 children with mental retardation without ADHD. The ADHD group had significantly more symptoms of depression, family conflict, noncompliance, anxiety, hyperactivity, inadequate social skills, and academic problems. Results are strongly suggestive of significant behavioral and emotional problems in children with ADHD and mental retardation, thus mirroring the pattern associated with ADHD in the general school-age population.


Assuntos
Sintomas Afetivos/diagnóstico , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Transtornos do Comportamento Infantil/diagnóstico , Deficiência Intelectual/diagnóstico , Adolescente , Sintomas Afetivos/psicologia , Transtorno do Deficit de Atenção com Hiperatividade/psicologia , Criança , Transtornos do Comportamento Infantil/psicologia , Comorbidade , Feminino , Humanos , Deficiência Intelectual/psicologia , Masculino , Determinação da Personalidade
7.
J Am Coll Nutr ; 19(3 Suppl): 331S-338S, 2000 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10875606

RESUMO

OBJECTIVE: The objective of this study was to provide national estimates of whole-grain intake in the United States, identify major dietary sources of whole grains and compare food and nutrient intakes of whole-grain consumers and nonconsumers. METHODS: Data were collected from 9,323 individuals age 20 years and older in USDA's 1994-96 Continuing Survey of Food Intakes by Individuals through in-person interviews on two non-consecutive days using a multiple-pass 24-hour recall method. Foods reported by respondents were quantified in servings as defined by the Food Guide Pyramid using a new database developed by the USDA. Whole-grain and nonwhole-grain servings were determined based on the proportion, by weight, of the grain ingredients in each food that were whole grain and nonwhole grain. Sampling weights were applied to provide national probability estimates adjusted for differential rates of selection and nonresponse. Then, t tests were used to assess statistically significant differences in intakes of nutrients and food groups by whole-grain consumers and nonconsumers. RESULTS: According to the 1994-96 survey, U.S. adults consumed an average of 6.7 servings of grain products per day; 1.0 serving was whole grain. Thirty-six percent averaged less than one whole-grain serving per day based on two days of intake data, and only eight percent met the recommendation to eat at least three servings per day. Yeast breads and breakfast cereals each provided almost one-third of the whole-grain servings, grain-based snacks provided about one-fifth, and less than one-tenth came from quick breads, pasta, rice, cakes, cookies, pies, pastries and miscellaneous grains. Whole-grain consumers had significantly better nutrient profiles than nonconsumers, including higher intakes of vitamins and minerals as percentages of 1989 Recommended Dietary Allowances and as nutrients per 1,000 kilocalories, and lower intakes of total fat, saturated fat and added sugars as percentages of food energy. Consumers were significantly more likely than nonconsumers to meet Pyramid recommendations for the grain, fruit and dairy food groups. CONCLUSION: Consumption of whole-grain foods by U.S. adults falls well below the recommended level. A large proportion of the population could benefit from eating more whole grain, and efforts are needed to encourage consumption.


Assuntos
Dieta , Grão Comestível , Adulto , Inquéritos sobre Dietas , Ingestão de Energia , Feminino , Humanos , Renda , Masculino , Rememoração Mental , Pessoa de Meia-Idade , Minerais/administração & dosagem , Política Nutricional , Estado Nutricional , Grupos Raciais , Estados Unidos , United States Department of Agriculture , Vitaminas/administração & dosagem
8.
Aquat Toxicol ; 49(1-2): 63-76, 2000 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-10814807

RESUMO

The toxicity of a water-accommodated fraction (WAF) prepared from weathered oil was assessed in a 7-day static renewal test with Mysidopsis bahia. Weathered oil was collected from the 5x monitoring well at the Guadalupe oil field. Solar ultraviolet and visible light intensities were measured in various habitats in the vicinity of the weathered oil sample collection site, and the resultant measurements were used to produce laboratory light treatments that were representative of the on-site quality and intensity of natural solar radiation. Each of five WAF dilutions and a control without WAF was tested under three different simulated solar radiation intensities. During the test, survival and growth of the mysids, irradiance, and total petroleum hydrocarbon (TPH) concentrations in the test treatments were measured. Significant increases (P

9.
Eur J Clin Nutr ; 54(4): 281-7, 2000 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10745278

RESUMO

OBJECTIVE: To partition the food reports of low energy reporters (LERs) and non-LERs into four aspects-tendency to report a given food, frequency of reports per user, portion sizes per mention, and the qualitative (low-fat, low-sugar, low-energy) differences of the reports-in order to determine what differentiates them from one another. ASSESSMENT METHOD: Two non-consecutive 24h dietary recalls. Low energy reporting was defined as energy intake lower than 80% of estimated basal metabolic rate. SETTING: In-home personal interviews. SUBJECTS: 8334 adults from a stratified, multi-stage area probability sample designed to be representative of noninstitutionlized persons residing in households in the United States. RESULTS: Across all different types of foods, there are those food groups which LERs are less likely to report (28 of 44 food groups), those which they report less frequently when they do report them (15 of 44 groups), and those for which they report smaller quantities per mention (26 of 44). Qualitative differences in the food choices-that is, differences in fat, sugar, and/or energy content-were not so widespread (4 of 24 food groups). CONCLUSIONS: The practical application of analyses such as these is to improve the methods of gathering dietary data so that this kind of bias can be reduced. Further methodological research is needed to reduce the likelihood of respondents neglecting to mention foods and underestimating portion sizes.


Assuntos
Dieta , Ingestão de Energia , Adulto , Índice de Massa Corporal , Inquéritos sobre Dietas , Etnicidade , Exercício Físico , Feminino , Humanos , Renda , Masculino , Rememoração Mental , Pessoa de Meia-Idade , Fumar , Estados Unidos
10.
Appl Environ Microbiol ; 66(2): 688-93, 2000 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-10653737

RESUMO

Enrichment culture experiments employing soil and water samples obtained from petroleum-contaminated environments succeeded in the isolation of a pure culture possessing the ability to utilize quinoline as a sole nitrogen source but did not utilize quinoline as a carbon source. This culture was identified as Pseudomonas ayucida based on a partial 16S rRNA gene sequence, and the strain was given the designation IGTN9m. Examination of metabolites using thin-layer chromatography and gas chromatography-mass spectrometry suggests that P. ayucida IGTN9m converts quinoline to 2-quinolinone and subsequently to 8-hydroxycoumarin. Resting cells of P. ayucida IGTN9m were shown to be capable of selectively removing about 68% of quinoline from shale oil in a 16-h treatment time. These results suggest that P. ayucida IGTN9m may be useful in petroleum biorefining for the selective removal of organically bound nitrogen from petroleum.


Assuntos
Poluentes Ambientais/metabolismo , Nitrogênio/metabolismo , Petróleo/metabolismo , Pseudomonas/metabolismo , Quinolinas/metabolismo , Biodegradação Ambiental , Cromatografia em Camada Fina , Cromatografia Gasosa-Espectrometria de Massas , Pseudomonas/crescimento & desenvolvimento , Microbiologia do Solo , Microbiologia da Água
11.
Ment Retard ; 37(5): 364-70, 1999 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-10581922

RESUMO

Although informant reports of everyday functioning are often used in dementia assessments, the actual correspondence between such indirect reports of functioning and actual performance has not been examined. Orientation results on the Dementia Questionnaire for Mentally Retarded Persons were compared to those obtained in direct assessment of orientation of 138 adults with mental retardation. Fair to good agreement was found between informant report and direct assessment. However, for some orientation items, nonverbal IQ, cause of mental retardation, and age affected the level of agreement. Thus, both informant report and direct measures of orientation are necessary in dementia assessments, and further work is needed on informant scale validation.


Assuntos
Cuidadores/psicologia , Demência/diagnóstico , Deficiência Intelectual/diagnóstico , Testes Neuropsicológicos/estatística & dados numéricos , Orientação , Atividades Cotidianas/psicologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Conscientização , Demência/psicologia , Síndrome de Down/diagnóstico , Síndrome de Down/psicologia , Feminino , Humanos , Deficiência Intelectual/psicologia , Estudos Longitudinais , Masculino , Variações Dependentes do Observador , Psicometria
12.
Environ Sci Pollut Res Int ; 6(4): 207-12, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-19005664

RESUMO

Traditionally, the toxic effects of petroleum have been investigated by conducting studies in the absence of ultraviolet radiation (UV). Photomediated toxicity is often not considered, and the toxic effects of an oil spill can be grossly underestimated. The toxicity of a weathered oil collected from a monitoring well at an abandoned oil field to Ceriodaphnia dubia was examined in the presence of UV. A solar simulator equipped with UVB, UVA, and cool white lamps was used to generate environmentally comparable solar radiation intensities.C. dubia were exposed to six concentrations of water accommodated fractions (WAF) of weathered oil in conjunction with three levels of laboratory simulated UV (Reference = < 0.002 microW/cm(2)UVB; 3.0 microW/cm(2) UVA; Low = 0.30 microW/cm(2) UVB; 75.0 microW/cm(2) UVA; High = 2.0 microW/cm(2) UVB; 340.0 microW/cm(2) UVA) and visible light. Seven day static renewal bioassays were used to characterize WAF/UV toxicity. WAF toxicity significantly (p < 0.05) increased when the organisms were exposed to WAF in the presence of UV. The photoenhanced toxicity of the WAF increased with WAF concentration within each UV regime. Relative to the reference light regime, the average number of neonates from adults exposed to 1.6 mg TPH/L decreased significantly by 20% within the low light regime, and by 60% within the high light regime. These results indicate that organisms exposed to dissolved-phase weathered oil in the presence of environmentally realistic solar radiation, exhibit 1.3-2.5 times greater sensitivity, relative to organisms exposed under traditional laboratory fluorescent lighting.

13.
Am J Ment Retard ; 103(2): 130-45, 1998 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-9779281

RESUMO

Although dementia associated with Down syndrome is often presumed to be progressive and irreversible, variations in disease course have been described. In addition, prevalence rates have varied widely among studies. This interim report is a description of the status of 70 adults with Down syndrome who are being followed for signs of dementia. Of the 70, 12 met all criteria for dementia, 40 met subsets of criteria, and 18 met no criteria. Information is provided on instruments used, rationale for choice and revision of instruments as well as criteria used to identify dementia and changes in the status of the participants. The results suggest that extreme care is needed when diagnosing dementia in adults with Down syndrome, for both clinical and research purposes.


Assuntos
Demência/complicações , Síndrome de Down/complicações , Adulto , Cognição , Demência/diagnóstico , Emoções , Feminino , Humanos , Masculino , Memória , Pessoa de Meia-Idade , Testes Psicológicos
17.
Pediatrics ; 100(3 Pt 1): 323-9, 1997 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-9282700

RESUMO

OBJECTIVES: To determine the proportion of youth meeting national recommendations for food group intake and to identify food intake patterns. DESIGN: The US Department of Agriculture's 1989-1991 Continuing Surveys of Food Intakes by Individuals were used to estimate food intake. Intake was determined from 3 days of diet by disaggregating foods into their component ingredients and using weights that correspond to servings. PARTICIPANTS: The sample included 3307 youth, 2 to 19 years of age, living in the 48 conterminous United States. Main Outcome Measures. Mean number of servings and percentage of individuals meeting national recommendations for food group intake according to demographic characteristics, patterns of intake, and nutrient profiles associated with each pattern. RESULTS: Mean numbers of servings per day were below minimum recommendations for all food groups except the dairy group (ages 2 to 11). Percentages of youth meeting recommendations ranged from approximately 30% for fruit, grain, meat, and dairy to 36% for vegetables. Sixteen percent of youth did not meet any recommendations, and 1% met all recommendations. The pattern of meeting all recommendations resulted in nutrient intakes above the recommended dietary allowances and was high in fat. Conversely, meeting none of the recommendations resulted in intakes well below the recommended dietary allowances for some nutrients. Total fat and added sugars averaged 35% and 15% of energy, respectively, and levels were similar among most demographic groups. CONCLUSION: Children and teens in the United States follow eating patterns that do not meet national recommendations. Nutrition education and intervention are needed among US children.


Assuntos
Ingestão de Alimentos , Política Nutricional , Adolescente , Adulto , Fatores Etários , Criança , Ciências da Nutrição Infantil/educação , Pré-Escolar , Laticínios , Dieta , Carboidratos da Dieta/administração & dosagem , Gorduras na Dieta/administração & dosagem , Grão Comestível , Ingestão de Energia , Comportamento Alimentar , Feminino , Alimentos , Frutas , Humanos , Masculino , Carne , Avaliação Nutricional , Valor Nutritivo , Fatores Sexuais , Estados Unidos , Verduras
18.
Am J Clin Nutr ; 65(4 Suppl): 1254S-1263S, 1997 04.
Artigo em Inglês | MEDLINE | ID: mdl-9094930

RESUMO

We describe a method for comparing food intakes reported in surveys with recommendations given in the US Department of Agriculture's food guide pyramid. Such comparison was previously difficult because many foods are eaten as mixtures that cannot be categorized into pyramid food groups and because food intake data and food recommendations are expressed in different units of measurement. We developed a recipe file showing ingredients at multiple levels of breakdown and used it to disaggregate food mixtures into their ingredients so that they could be placed into pyramid food groups. Food-specific weight consistent with the pyramid definitions for serving sizes were derived from the food code book of the 1989-1991 Continuing Survey of Food Intakes by Individuals and used to develop a serving-weight file. Data collected from 8181 adults aged > or = 20 y in the survey were used to estimate the mean number of servings from pyramid food groups and percentages of the population meeting pyramid recommendations. The mean numbers of servings were close to the minimum recommendations for the grain, vegetable, and meat groups and well below the minimum recommendations for the fruit and dairy groups. large proportions of adults (43-72%) failed to meet the dietary recommendations. Our method has several nutrition monitoring and nutrition education applications.


Assuntos
Alimentos , Avaliação Nutricional , Política Nutricional , Adulto , Inquéritos sobre Dietas , Carboidratos da Dieta/administração & dosagem , Gorduras na Dieta/administração & dosagem , Ingestão de Energia , Etnicidade , Feminino , Humanos , Masculino , Rememoração Mental , Pessoa de Meia-Idade , Pobreza , Grupos Raciais , Estados Unidos , United States Department of Agriculture
19.
Am J Clin Nutr ; 65(4 Suppl): 1264S-1268S, 1997 04.
Artigo em Inglês | MEDLINE | ID: mdl-9094931

RESUMO

Food-pattern analysis provides a way to examine diets in a multidimensional context. This study examined the diets of 8181 adults in the 1989-1991 Continuing Survey of Food Intakes by Individuals and evaluated whether they met the federal recommendations for each of five food groups. The sample was partitioned among 32 different food-intake patterns, six of which represented 44% of the population. Nutrient profiles associated with each of the patterns indicated that failure to meet one or more of the food-group recommendations was associated with nutrient inadequacy, macronutrient imbalance, or both. A reexamination of the data to account for low energy reporters did not alter these findings. The pattern of meeting all five of the food-group recommendations was among the least common, accounting for only 1% of adults' intakes.


Assuntos
Inquéritos sobre Dietas , Dieta , Alimentos , Avaliação Nutricional , Adulto , Negro ou Afro-Americano , Ingestão de Energia , Feminino , Hispânico ou Latino , Humanos , Masculino , Política Nutricional , Fenômenos Fisiológicos da Nutrição , População Branca
20.
Genetics ; 142(3): 935-44, 1996 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-8849899

RESUMO

Mutations at the Steel (Sl) locus produce pleiotropic effects on viability as well as hematopoiesis, pigmentation and fertility. Several homozygous viable Sl alleles have previously been shown to contain either structural alterations in mast cell growth factor (Mgf) or regulatory mutations that affect expression of the Mgf gene. More severe Sl alleles cause lethality to homozygous embryos and all lethal Sl alleles examined to date contain deletions that remove the entire Mgf coding region. As the timing of the lethality varies from early to late in gestation, it is possible that some deletions may affect other closely linked genes in addition to Mgf. We have analyzed the extent of deleted sequences in seven homozygous lethal Sl alleles. The results of this analysis suggest that late gestation lethality represents the Sl null phenotype and that peri-implantation lethality results from the deletion of at least one essential gene that maps proximal to Sl. We have also examined gene dosage effects of Sl by comparing the phenotypes of mice homozygous and hemizygous for each of four viable Sl alleles. Lastly, we show that certain combinations of the viable Sl alleles exhibit interallelic complementation. Possible mechanisms by which such complementation could occur are discussed.


Assuntos
Fator de Células-Tronco/genética , Alelos , Animais , Feminino , Deleção de Genes , Genes Letais , Teste de Complementação Genética , Masculino , Camundongos , Camundongos Endogâmicos C3H , Camundongos Endogâmicos C57BL , Camundongos Mutantes
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