1.
Pharmacol Biochem Behav
; 46(4): 995-7, 1993 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8309981
RESUMO
The possibility that benzodiazepine-induced hyperglycaemia is mediated through the release of endogenous endorphins was tested. The results show that naloxone, the opiate antagonist, potentiated clonazepam-induced hyperglycaemia. Treatment with increasing doses of morphine for six days, which induced tolerance to endorphins, did not affect clonazepam-induced hyperglycaemia. The results indicate that endorphins do not mediate benzodiazepine-induced hyperglycaemia.