Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy: A retrospective analysis of a prospective cohort.

BACKGROUND: Laparoscopic cholecystectomy (LC) is one of the most frequently performed surgical procedures. Cystic stump leakage is an underestimated, potentially life threatening complication that occurs in 1%-6% of the patients. With a secure cystic duct occlusion technique during LC, bile leakage becomes a preventable complication. AIM: To investigate the effect of polydioxanone (PDS) loop closure of the cystic duct on bile leakage rate in LC patients. METHODS: In this retrospective analysis of a prospective cohort, the effect of PDS loop closure of the cystic duct on bile leakage complication was compared to patients with conventional clip closure. Logistic regression analysis was used to develop a risk score to identify bile leakage risk. Leakage rate was assessed for categories of patients with increasing levels of bile leakage risk. RESULTS: Of the 4359 patients who underwent LC, 136 (3%) underwent cystic duct closure by a PDS loop. Preoperatively, loop closure patients had significantly more complicated biliary disease compared to the clipped closure patients. In the loop closure cohort, zero (0%) bile leakage occurred compared to 59 of 4223 (1.4%) clip closure patients. For patients at increased bile leakage risk (risk score ≥ 1) rates were 1.6% and up to 13% (4/30) for clip closure patients with a risk score ≥ 4. This risk increase paralleled a stepwise increase of actual bile leakage complication for clip closure patients, which was not observed for loop closure patients. CONCLUSION: Cystic duct closure with a PDS loop during LC may reduce bile leakage in patients at increased risk for bile leakage.

Trauma and psychiatric disorders: A systematic review.

BACKGROUND: Suicide is currently a topic of high priority for policy-makers, researchers and clinicians. The World Health Organization estimated 804,000 suicide deaths worldwide in 2012. Some studies that focused on patients with self-inflicted injury revealed that mortality in this group is higher than for patients who sustain unintentional injury. However little is known about the impact of psychiatric disorders on health care resources including length of hospital stay. OBJECTIVES: To determine whether trauma patients with a psychiatric disorder or after attempting suicide are at higher risk of a complicated course than patients without a psychiatric disorder or accidental cause. The secondary objective was to provide an overview of the current literature on the same group of trauma patients with psychiatric comorbidity in regard to mortality rate, length of stay, hospital costs and quality of life. Our primary outcome measure, complicated course, was found to be most clinically relevant. METHODS: We searched PubMed, Embase and PsycInfo electronic databases. All searches were updated to March 2016. The methodological quality was assessed using the QUIPS tool. RESULTS: Our search identified 9284 articles (PubMed 3660, Embase 2590, PsycInfo 3034). Of these, 18 articles were included. Four studies investigated the association between psychiatric disorders and a complicated course after trauma, three found a significant higher risk of complications. Mortality was reviewed in 14 studies, of which seven showed significant higher risk of in-hospital mortality for trauma patients with psychiatric disorder. Eight of nine studies found significant prolonged length of stay for these patients. CONCLUSION: Patients who have a psychiatric disorder or who have attempted suicide are at higher risk of increased in-hospital mortality and prolonged length of stay after sustaining injuries. These patients also tend to be at higher risk of complications after severe trauma, however future research is needed to confirm these potentially important implications. LEVEL OF EVIDENCE: Systematic review, level III.

[Falling from a height: Psychiatric comorbidity and complications]. / Vallen van een hoogte: Psychiatrische comorbiditeit en complicaties.

OBJECTIVE: To investigate whether a mental disorder increases the occurrence of complications in patients after 'a fall from a height'. DESIGN: Retrospective descriptive study. METHODS: Data on all patients admitted following a 'fall from a height' in the period 2004-2012 was retrieved from the trauma registry of the Academic Medical Center (AMC) in Amsterdam, the Netherlands. This was combined with data from the National Surgical Complications Registry (LHCR). A chart review was conducted to determine the presence of mental disorders in these patients. Corrected risk ratio for the risk of complications in patients with a psychological disorder was calculated using the Mantel-Haenszel method. RESULTS: A total of 507 patients presented to the emergency department at the AMC following a fall from a height; 147 patients (29%) experienced 1 or more complications and 131 patients (25.8%) had a mental disorder. Complications arose in 60 patients with a mental disorder (45.8%) and in 87 patients (23.1%) without a mental disorder. The corrected risk ratio showed that a mental disorder is a statistically significant independent predictor of complications (risk ratio: 1.58; 95% confidence interval: 1.21-2.06). CONCLUSION: The risk of complications following a fall from a height in patients with a mental disorder is one and a half times higher than in patients without a mental disorder. This mental disorder is a significant independent predictor of a medical complication following a fall from a height.

Surgeon's volume is not associated with complication outcome after laparoscopic cholecystectomy.

AIM: Complication rates after laparoscopic cholecystectomy vary but are still reported to be up to 17 %. Identifying risk factors for an adverse complication outcome could help to reduce morbidity after laparoscopic cholecystectomy. Our aim was to analyze whether surgeon volume is a vital issue for complication outcome. METHODS: All complications-minor, major, local and general-were reviewed in a single institution between January 2004 and December 2008 and recorded in a database. Patient's variables, disease related variables and surgeon's variables were noted. The role of surgeon's individual volume per year was analyzed. A stepwise logistic regression model was used. RESULTS: A total of 942 patients were analyzed, among which 70 (7 %) patients with acute cholecystitis and 52 (6 %) patients with delayed surgery for acute cholecystitis. Preoperative endoscopic retrograde cholangiography (ERC) had been performed in 142 (15 %) patients. Complication rates did not differ significantly for surgeon's individual volume (≤10 vs. >10 LC/year, 5.2 vs. 8.2 %, p = 0.203) nor for specialization (laparoscopic vs. non-laparoscopic; 9.2 vs. 6.4 %, p = 0.085) and experience (specialty registration ≤5 vs. >5 years; 5.1 vs. 8.7 %, p = 0.069). The only significant predictors for complications were acute surgery (OR 3.9, 95 % CI 1.8-8.7, p = 0.001) and a history preceding laparoscopic cholecystectomy (LC) (ERC and delayed surgery for cholecystitis) (OR 8.1, 95 % CI 4.5-14.6: p <0.001). CONCLUSION: Complications after LC were not significantly associated with a surgeon's individual volume, but most prominently determined by the type of biliary disease.