1.
Bioorg Med Chem Lett
; 16(22): 5859-63, 2006 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16942874
RESUMO
A novel class of tetrahydroindolone-derived semicarbazones has been discovered as potent Kv1.5 blockers. In in vitro studies, several compounds exhibited very good potency for blockade of Kv1.5. Compound 8i showed good selectivity for blockade of Kv1.5 vs hERG and L-type calcium channels. In an anesthetized pig model, compounds 8i and 10c increased atrial ERP about 28%, 18%, respectively, in the right atrium without affecting ventricular ERP.