1.
Bioorg Med Chem Lett
; 10(10): 1069-72, 2000 May 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10843219
RESUMO
A new class of conformationally constrained thrombin inhibitors is described. These compounds contain a unique bicyclic pyridone scaffold which serves as a P3P2 dipeptide surrogate. The synthesis and antithrombotic activity of these inhibitors is reported.