RESUMO
Eight 4-week-old broiler chickens were used to study the effects of dietary citrinin on water consumption, urine excretion, and fecal moisture. The birds were colostomized by exteriorizing the colon directly below the vent. Plastic bags were attached to collect feces. Corn containing the various levels of citrinin was fed for 4 hr. Water consumption and urine excretion were measured, and fecal samples were retained for moisture determination. Analysis of variance indicated citrinin increased (p less than 0.05) both water consumption and urine excretion. Regression analysis isolated the linear component as being significant (p less than 0.05) for both water consumption and urine excretion, identifying the responses as linear through the bounds of the treatment levels. Fecal moisture showed no changes (p less than 0.05). The correlation coefficients yielded significant relationships between treatment vs. water consumption, treatment vs urine excretion and water consumption vs urine excretion.
Assuntos
Benzopiranos/farmacologia , Galinhas/urina , Citrinina/farmacologia , Urina/análise , Animais , Galinhas/metabolismo , Citrinina/toxicidade , Dieta , Ingestão de Líquidos/efeitos dos fármacos , Fezes/análise , Rim/efeitos dos fármacos , Água/metabolismoRESUMO
Three coyotes experimentally implanted with cells from a transmissible venereal tumor of a dog developed neoplasms. Histopathologic appearances of the tumors in the coyotes were similar to those described in the dog. Attempts to transmit the tumor to suckling mice, rats, hamsters, kittens, and opossums were not successful.
Assuntos
Carnívoros , Doenças do Cão/transmissão , Tumores Venéreos Veterinários/transmissão , Animais , Doenças do Cão/patologia , Cães , Feminino , Masculino , Tumores Venéreos Veterinários/patologiaRESUMO
Ultrastructural study of canine transmissible tumors in developing, mature, and regressing stages from 6 dogs revealed the presence of healthy and degenerating tumor cells in all neoplasms. The total number of neoplastic cells seemed to decrease, and the number of degenerating neoplastic cells seemed to increase in mature tumors. Macrophages, lymphocytes, and plasma cells infiltrated mature and regressing tumors. Alteratons in degenerating tumor cells consisted mainly of cytoplasmic changes in early stages and of both nuclear and cytoplasmic changes in cells in which degeneration was more advanced. Amounts of endoplasmic reticulum and ribosomes were decreased. There were swelling and vacuolation of mitochondria. Nuclear chromatin was clumped along the nuclear envelope, and the perinuclear space was widened. Degenerating cells often contained membrane-bound granules and clusters. Lamellar complexes were observed in tumor cells from 2 dogs. Virus particles were not seen.