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1.
Int J Mol Sci ; 23(6)2022 Mar 20.
Artigo em Inglês | MEDLINE | ID: mdl-35328775

RESUMO

The extraction of electron-liquid phase cross-sections (surface and bulk) is proposed through the measurement of (differential) energy loss spectra for electrons scattered from a liquid micro-jet. The signature physical elements of the scattering processes on the energy loss spectra are highlighted using a Monte Carlo simulation technique, originally developed for simulating electron transport in liquids. Machine learning techniques are applied to the simulated electron energy loss spectra, to invert the data and extract the cross-sections. The extraction of the elastic cross-section for neon was determined within 9% accuracy over the energy range 1-100 eV. The extension toward the simultaneous determination of elastic and ionisation cross-sections resulted in a decrease in accuracy, now to within 18% accuracy for elastic scattering and 1% for ionisation. Additional methods are explored to enhance the accuracy of the simultaneous extraction of liquid phase cross-sections.


Assuntos
Elétrons , Transporte de Elétrons , Estudos de Viabilidade , Método de Monte Carlo , Fenômenos Físicos , Espalhamento de Radiação
2.
J Math Biol ; 78(6): 1713-1725, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30737545

RESUMO

We investigate the global dynamics of a general Kermack-McKendrick-type epidemic model formulated in terms of a system of renewal equations. Specifically, we consider a renewal model for which both the force of infection and the infected removal rates are arbitrary functions of the infection age, [Formula: see text], and use the direct Lyapunov method to establish the global asymptotic stability of the equilibrium solutions. In particular, we show that the basic reproduction number, [Formula: see text], represents a sharp threshold parameter such that for [Formula: see text], the infection-free equilibrium is globally asymptotically stable; whereas the endemic equilibrium becomes globally asymptotically stable when [Formula: see text], i.e. when it exists.


Assuntos
Número Básico de Reprodução , Doenças Transmissíveis/epidemiologia , Epidemias/prevenção & controle , Modelos Biológicos , Doenças Transmissíveis/transmissão , Simulação por Computador , Epidemias/estatística & dados numéricos , Humanos , Fatores de Tempo
3.
Math Biosci ; 296: 82-92, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29288702

RESUMO

We introduce and analyze coupled, multi-strain epidemic models designed to simulate the emergence and dissemination of mutant (e.g. drug-resistant) pathogen strains. In particular, we investigate the mathematical and biological properties of a general class of multi-strain epidemic models in which the infectious compartments of each strain are coupled together in a general manner. We derive explicit expressions for the basic reproduction number of each strain and highlight their importance in regulating the system dynamics (e.g. the potential for an epidemic outbreak) and the existence of nonnegative endemic solutions. Importantly, we find that the basic reproduction number of each strain is independent of the mutation rates between the strains - even under quite general assumptions for the form of the infectious compartment coupling. Moreover, we verify that the coupling term promotes strain coexistence (as an extension of the competitive exclusion principle) and demonstrate that the strain with the greatest reproductive capacity is not necessarily the most prevalent. Finally, we briefly discuss the implications of our results for public health policy and planning.


Assuntos
Bactérias/genética , Bactérias/patogenicidade , Número Básico de Reprodução , Doenças Transmissíveis/microbiologia , Resistência Microbiana a Medicamentos , Epidemias , Modelos Teóricos , Humanos
4.
Phys Chem Chem Phys ; 13(42): 18724-33, 2011 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-21822510

RESUMO

The bound states of the fermionic (3)He(2 (3)S(1)) + (3)He(2 (3)P(j)) system, where j = 0, 1, 2, are investigated using the recently available ab initio short-range (1,3,5)Σ(+)(g,u) and (1,3,5)Π(g,u) potentials computed by Deguilhem et al. (J. Phys. B: At., Mol. Opt. Phys., 2009, 42, 015102). Single-channel and multichannel calculations have been undertaken in order to investigate the effects of Coriolis and non-adiabatic couplings. The possible experimental observability of the theoretical levels is assessed using criteria based upon the short-range character of each level and their coupling to metastable ground states. Purely long-range levels have been identified and 30 short-range levels near five asymptotes are suggested for experimental investigation.

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