RESUMO
PURPOSE: In order to assess the occurrence of adverse ocular effects of antipsychotic drugs, we sought to evaluate intraocular pressure of schizophrenic patients treated with psychiatric medications. METHODS: Twenty-eight outpatients with DSM-IV diagnosis of schizophrenia who met both the inclusion and exclusion criteria were submitted to an ophthalmic evaluation for ocular abnormalities which included intraocular pressure measurement with Goldmann applanation tonometry. RESULTS: Raised intraocular pressure was found in three patients (11%). Abnormality in cup-disc ratio was seen in only one patient with cup-disc ratio asymmetry of 0.4. All these four patients were taking only ziprasidone. CONCLUSIONS: Patients using ziprasidone were found to have abnormalities in both intraocular pressure and cup-disc ratio.
Assuntos
Antipsicóticos/efeitos adversos , Pressão Intraocular/efeitos dos fármacos , Esquizofrenia/tratamento farmacológico , Adulto , Antipsicóticos/uso terapêutico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Tonometria Ocular , Adulto JovemRESUMO
PURPOSE: In order to assess the occurrence of adverse ocular effects of antipsychotic drugs, we sought to evaluate intraocular pressure of schizophrenic patients treated with psychiatric medications. METHODS: Twenty-eight outpatients with DSM-IV diagnosis of schizophrenia who met both the inclusion and exclusion criteria were submitted to an ophthalmic evaluation for ocular abnormalities which included intraocular pressure measurement with Goldmann applanation tonometry. RESULTS: Raised intraocular pressure was found in three patients (11 percent). Abnormality in cup-disc ratio was seen in only one patient with cup-disc ratio asymmetry of 0.4. All these four patients were taking only ziprasidone. CONCLUSIONS: Patients using ziprasidone were found to have abnormalities in both intraocular pressure and cup-disc ratio.
OBJETIVO: Para avaliar a ocorrência de efeitos adversos oculares dos antipsicóticos, buscamos avaliar a pressão intra-ocular em pacientes esquizofrênicos tratados com medicações psiquiátricas. MÉTODOS: Vinte e oito pacientes tratados ambulatorialmente com diagnóstico de esquizofrenia segundo o DSM-IV que preencheram os critérios de inclusão e exclusão foram submetidos a uma avaliação oftalmológica para pesquisa de alterações oculares que incluiu a medida da pressão intra-ocular com tonometria de aplanação de Goldmann. RESULTADOS: Pressão intra-ocular aumentada foi encontrada em 3 pacientes (11 por cento). Anormalidade na escavação do disco óptico foi observada em apenas um paciente com assimetria de escavação de 0,4. Todos esses quatro pacientes estavam usando apenas ziprasidona. CONCLUSÕES: Pacientes em uso de ziprasidona apresentaram anormalidades na pressão intra-ocular e na escavação do disco óptico.