RESUMO
The purpose of this study was to examine kinematic, kinetic, and muscle activation metrics during countermovement jumps (CMJs) with varying countermovement depths. The hypothesis was that a shallow countermovement depth would compromise jump height by disrupting neuromechanical control. Ten healthy men (age 26 ± 8 yr, height 1.81 ± 0.08 m, mass 83.5 ± 9.0 kg) performed maximal CMJs at self-selected countermovement depth (self-selected CMJ), at reduced countermovement depth (shallow CMJ), and at increased countermovement depth (deep CMJ). Three jumps were performed in each condition on force plates with ankle, knee, and hip motion recorded and electromyograms (EMG) recorded from the gluteus maximus (GM), vastus lateralis (VL), and medial gastrocnemius (MG) muscles. During CMJs, the knee flexion angle was recorded with an electrogoniometer. Jumpers were instructed to flex at least 15% less (shallow CMJ) and at least 15% more (deep CMJ) than the self-selected CMJs. Kinematic, kinetic, and EMG metrics were compared between the different CMJ depths using repeated measures ANOVA. Compared with self-selected CMJs, shallow CMJs had 26% less countermovement depth (P < 0.001, effect size 1.74) and the deep CMJs had 28% greater countermovement depth (P < 0.001, effect size 1.56). Jump height was 8% less for the shallow vs. self-selected CMJs (P = 0.007, effect size 1.09) but not different between self-selected and deep CMJs (P = 0.254). Shallow CMJs differed from self-selected CMJs at the initiation of the countermovement (unweighting). For self-selected CMJs, force dropped to 43% of body weight during unweighting but only to 58% for shallow CMJs (P = 0.015, effect size 0.95). During unweighting, VL EMG averaged 5.5% of MVC during self-selected CMJs versus 8.1% for shallow CMJs (P = 0.014, effect size 0.97). Percent decline in jump height with shallow versus self-selected CMJs was correlated with the difference in VL EMG during unweighting between shallow and self-selected CMJs (r = 0.651, P = 0.041). A deep countermovement prolonged the time to execute the jump by 38% (P < 0.010, effect size 1.04) but did not impair CMJ force metrics. In conclusion, self-selected countermovement depth represents a tradeoff between dropping the center of mass sufficiently far and executing the jump quickly. Unweighting at the initiation of a CMJ appears to be a critical element in the neuromechanics of the CMJ.
RESUMO
BACKGROUND: Although mitochondrial dysfunction is consistently manifested in patients with Type 2 Diabetes mellitus (T2DM), the association of mitochondrial DNA (mtDNA) sequence variants with T2DM varies among populations. These differences might stem from differing environmental influences among populations. However, other potentially important considerations emanate from the very nature of mitochondrial genetics, namely the notable high degree of partitioning in the distribution of human mtDNA variants among populations, as well as the interaction of mtDNA and nuclear DNA-encoded factors working in concert to govern mitochondrial function. We hypothesized that association of mtDNA genetic variants with T2DM could be revealed while controlling for the effect of additional inherited factors, reflected in family history information. METHODS: To test this hypothesis we set out to investigate whether mtDNA genetic variants will be differentially associated with T2DM depending on the diabetes status of the parents. To this end, association of mtDNA genetic backgrounds (haplogroups) with T2DM was assessed in 1055 Jewish patients with and without T2DM parents ('DP' and 'HP', respectively). RESULTS: Haplogroup J1 was found to be 2.4 fold under-represented in the 'HP' patients (p = 0.0035). These results are consistent with a previous observation made in Finnish T2DM patients. Moreover, assessing the haplogroup distribution in 'DP' versus 'HP' patients having diabetic siblings revealed that haplogroup J1 was virtually absent in the 'HP' group. CONCLUSION: These results imply the involvement of inherited factors, which modulate the susceptibility of haplogroup J1 to T2DM.
