RESUMO
A series of N-alkyl derivatives of 3,4-methylenedioxyamphetamine (MDA) was prepared in an effort to characterize these potential drugs of abuse. These secondary amines were synthesized via reductive amination of the corresponding ketone with alkylamines. The ultraviolet absorption spectra for these compounds produced almost equally intense absorbance at 234 and 285 nm. The compounds were separated by liquid chromatography using reverse phase (C18) procedures with a ternary mobile phase mixture. Toxicity studies showed all of the compounds to have LD50 values similar to N-methyl MDA (MDMA).
Assuntos
3,4-Metilenodioxianfetamina/síntese química , Anfetaminas/síntese química , 3,4-Metilenodioxianfetamina/análogos & derivados , 3,4-Metilenodioxianfetamina/toxicidade , Animais , Fenômenos Químicos , Química , Espectroscopia de Ressonância Magnética , Masculino , Camundongos , Camundongos Endogâmicos ICR , Espectrofotometria UltravioletaRESUMO
Amphetamine samples obtained from clandestine laboratories often contain other by-product amines. The most common of these are the alpha-benzylphenethylamine derivatives. This article reports the independent synthesis of reference samples of these amines, spectrophotometric and chromatographic methods for their identification, as well as acute toxicological studies. The utility of the analytical methods is demonstrated by the analysis of several amphetamine samples containing these alpha-benzylphenethylamines.
Assuntos
Anfetamina/análise , Contaminação de Medicamentos/análise , Drogas Ilícitas/análise , Metanfetamina/análogos & derivados , Metanfetamina/análise , Preparações Farmacêuticas/análise , Fenetilaminas/análise , Cromatografia Líquida , Indicadores e Reagentes , Isotiocianatos , Dose Letal Mediana , Espectrofotometria Infravermelho , Tiocianatos/análiseRESUMO
Combination of repeated administration of phenylbutazone (7 mg/kg for two weeks) or phenytoin (20 mg/kg for four weeks) and acute exposure to gamma radiation (696 REM) induced increased lethality in mice much greater than that observed fro use of either drug or radiation alone. Lethality in chronic hydralazine (10 mg/kg for four weeks) treated mice subjected also to gamma radiation was not different than that observed after either drug or radiation alone. Decrease in liver glutathione was observed in mice receiving combined drug-radiation treatment as also were leucocyte counts, but neither of these parameters supported as assumption of site of common lethal mechanism.
