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1.
Res Dev Disabil ; 80: 153-160, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30015273

RESUMO

BACKGROUND: Although cord blood (CB) stem cell research is being conducted for treatment of cerebral palsy (CP), little is known about children with CP and stored CB. AIMS: To compare demographic and clinical characteristics of children with CP and stored CB to children with CP identified in a population-based study. METHODS AND PROCEDURES: The Longitudinal Umbilical Stem cell monitoring and Treatment REsearch (LUSTRE®) Registry recruited children from the largest US private CB bank. Demographics, co-morbidities, and gross motor function (GMFCS level and walking ability) were collected and, where possible, compared with the CDC's Autism and Developmental Disabilities Monitoring (ADDM) Network. OUTCOMES AND RESULTS: 114 LUSTRE participants were compared to 451 ADDM participants. LUSTRE participants were more likely to be white, but sex distribution was similar. Co-morbidities (autism and epilepsy) and functional mobility were also similar. CONCLUSIONS AND IMPLICATIONS: The results of this analysis suggest that while children diagnosed with CP and with access to stored CB differ from a broader population sample in terms of demographics, they have similar clinical severity and comorbidity profiles. As such, LUSTRE may serve as a valuable source of data for the characterization of individuals with CP, including individuals who have or will receive CB infusions.


Assuntos
Transtorno Autístico/epidemiologia , Bancos de Sangue/estatística & dados numéricos , Paralisia Cerebral/epidemiologia , Epilepsia/epidemiologia , Sangue Fetal , Sistema de Registros , População Branca/estatística & dados numéricos , Adolescente , Paralisia Cerebral/fisiopatologia , Criança , Pré-Escolar , Comorbidade , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Índice de Gravidade de Doença , Distribuição por Sexo
2.
Matern Child Health J ; 21(1): 208-214, 2017 01.
Artigo em Inglês | MEDLINE | ID: mdl-27531008

RESUMO

Introduction Little is known about the prevalence of conditions potentially amenable to cellular therapy among families storing umbilical cord blood in private cord blood banks. Methods A cross-sectional study of families with at least one child who stored umbilical cord blood in the largest private cord blood bank in the United States was performed. Respondent families completed a questionnaire to determine whether children with stored cord blood or a first-degree relative had one or more of 16 conditions amenable primarily to allogeneic stem cell transplant ("transplant indications") or 16 conditions under investigation for autologous stem cell infusion ("regenerative indications"), regardless of whether they received a transplant or infusion. Results 94,803 families responded, representing 33.3 % of those surveyed. Of respondent families, 16.01 % indicated at least one specified condition. 1.64 % reported at least one first-degree member with a transplant indication potentially treatable with an allogeneic stem cell transplant. The most common transplant indications reported among first-degree family members were Non-Hodgkin's Lymphoma (0.33 %), Hodgkin's Lymphoma (0.30 %), and Acute Lymphoblastic Leukemia (0.28 %). 4.23 % reported at least one child with a regenerative indication potentially treatable with an autologous stem cell infusion. The most common regenerative indications among children with stored umbilical cord blood were Autism/Autism Spectrum Disorder/Apraxia (1.93 %), Other Developmental Delay (1.36 %), and Congenital Heart Defect (0.87 %). Discussion Among families storing umbilical cord blood in private cord blood banks, conditions for which stem cell transplant or infusion may be indicated, or are under investigation, appear to be prevalent, especially for regenerative medicine indications.


Assuntos
Transplante de Células-Tronco de Sangue do Cordão Umbilical/métodos , Sangue Fetal/citologia , Prevalência , Anemia/genética , Anemia/terapia , Transplante de Células-Tronco de Sangue do Cordão Umbilical/estatística & dados numéricos , Estudos Transversais , Humanos , Leucemia/genética , Leucemia/terapia , Linfoma/genética , Linfoma/terapia , Administração de Materiais no Hospital/métodos , Administração de Materiais no Hospital/estatística & dados numéricos , Medicina Regenerativa/métodos , Medicina Regenerativa/estatística & dados numéricos , Sarcoma/genética , Sarcoma/terapia , Inquéritos e Questionários , Estados Unidos
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