Spectroscopic Monitoring and Modeling Drug Dissolution for Undergraduate Chemistry Curriculum.

The pharmaceutical and medicine manufacturing industry has become the largest industrial sector for the employment of chemists, indicating a need for experiments with a pharmaceutical sciences context in the undergraduate chemistry curriculum. In the pharmaceutical industry, testing drug dissolution is a key analytical task for solid oral dosage forms that is performed in different phases of drug development to test the release behavior of new formulations, ensure consistency between manufacturing lots, and help predict the in vivo absorption of the drug substance after administration. However, there are a limited number of laboratory experiments in dissolution testing developed for the undergraduate chemistry curriculum. To help students obtain hands-on experience in dissolution testing, a protocol has been developed for an undergraduate chemistry laboratory course for students to build a dissolution apparatus, monitor dissolution processes, model the dissolution to extract kinetic parameters, and evaluate the consistency between dissolution curves with FDA regulated methods. Students successfully collected dissolution curves and completed the modeling analysis with nonlinear least-squares fitting. The designed dissolution protocol has been evaluated to have consistency and reproducibility to be implemented in the undergraduate chemistry laboratory curriculum.

Let Students Work: Analysis of the Role of Differing Facilitation on Student Engagement in a Large Stadium-Style Lecture Hall.

The classroom environment is shaped by factors such as facilitation style, curricular design, and classroom layout. These factors are all inputs into student framing of the classroom environment and affect a student's comfort interacting within it. Promoting student discourse in active learning environments provides students the opportunity to explain their thinking and develop their understanding of natural phenomena. However, successfully implementing these practices in large lecture environments is often difficult. Undergraduate introductory chemistry lectures were investigated to identify the effects that instructional practices had on student engagement. Instructor facilitation, question level, and student interactions were analyzed and compared to provide insights into what instructional practices may promote or hinder student engagement in a large enrollment course. Overall instructors were positioning themselves as an authority on knowledge in the classroom by leading questions authoritatively like instructor-focused didactic lecturing that led to a decrease in student engagement. These results highlight the complexity of the classroom ecosystem related to student interactions and the role that facilitation plays in social and cognitive engagement.