Establishment of new design criteria for GlidCop® X-ray absorbers.

An engineering research program has been conducted at the Advanced Photon Source (APS) in order to determine the thermomechanical conditions that lead to crack formation in GlidCop®, a material commonly used to fabricate X-ray absorbers at X-ray synchrotron facilities. This dispersion-strengthened copper alloy is a proprietary material and detailed technical data of interest to the synchrotron community is limited. The results from the research program have allowed new design criteria to be established for GlidCop® X-ray absorbers based upon the thermomechanically induced fatigue behavior of the material. X-ray power from APS insertion devices was used to expose 30 GlidCop® samples to 10000 thermal loading cycles each under various beam power conditions, and all of the samples were metallurgically examined for crack presence/geometry. In addition, an independent testing facility was hired to measure temperature-dependent mechanical data and uniaxial mechanical fatigue data for numerous GlidCop® samples. Data from these studies support finite element analysis (FEA) simulation and parametric models, allowing the development of a thermal fatigue model and the establishment of new design criteria so that the thermomechanically induced fatigue life of X-ray absorbers may be predicted. It is also demonstrated how the thermal fatigue model can be used as a tool to geometrically optimize X-ray absorber designs.

Effects of a Short-Duration Stretching Drill After Pitching on Elbow and Shoulder Range of Motion in Professional Baseball Pitchers.

BACKGROUND: A glenohumeral internal rotation (IR) deficit or a total rotational motion (IR plus external rotation [ER]) deficit in the throwing shoulder compared with the nonthrowing shoulder has been shown to increase the risk of shoulder and elbow injuries. After a pitching session, both IR and total rotational motion deficits have been shown to occur naturally for an extended period of time in asymptomatic pitchers, but it is unclear how to best control these deficits between pitching sessions. Purpose/Hypothesis: The purpose of this study was to determine whether performing a short-duration stretching/calisthenics drill after pitching will result in an increase in IR, ER, total rotational motion, and elbow extension in professional baseball pitchers. It was hypothesized that these shoulder and elbow passive range of motion (PROM) measurements would all decrease after pitching but would subsequently return to prepitching values after the short-duration stretching/calisthenics drill. STUDY DESIGN: Controlled laboratory study. METHODS: A convenience sample of 20 male professional baseball pitchers served as study participants. The following sequence of activities was performed for all participants: (1) a 5- to 10-minute dynamic warm-up consisting of running and light throwing, (2) elbow extension and IR and ER PROM measurements taken before pitching, (3) 40 full-effort pitches off the pitching mound, (4) 8 minutes of rest, (5) elbow extension and IR and ER PROM measurements taken after pitching, (6) a short-duration stretching/calisthenics drill (two-out drill), and (7) elbow extension and IR and ER PROM measurements taken after the two-out drill. A 1-way repeated-measures analysis of variance ( P < .05) was employed to assess differences in elbow extension, IR, ER, and total rotational motion in the 3 measurement conditions (prepitching, postpitching, and postdrill). To assess intrarater and interrater reliability, intraclass correlation coefficients (ICCs) were calculated, and the measurement error was calculated using the standard error of measurement (SEM). RESULTS: Significant differences were observed among the 3 conditions for ER ( P = .002), IR ( P = .027), and total rotational motion ( P < .001), but there was no significant difference in elbow extension ( P = .117). Bonferroni post hoc analyses revealed (1) significantly greater ER during prepitching and postdrill versus the postpitching condition (94° ± 7° [prepitching] and 94° ± 8° [postdrill] vs 88° ± 8°; P = .010 and .005, respectively), (2) significantly greater IR during prepitching and postdrill versus the postpitching condition (36° ± 10° [prepitching] and 35° ± 9° [postdrill] vs 30° ± 10°; P = .034 and .043, respectively), and (3) significantly greater total rotational motion during prepitching and postdrill versus the postpitching condition (129° ± 13° [prepitching] and 129° ± 13° [postdrill] vs 119° ± 13°; P = .034 and .004, respectively). There were no significant differences in ER, IR, or total rotational motion between the prepitching and postdrill conditions ( P > .999 for all). The intrarater reliability (ICC3,1) was 0.91 for ER (SEM, 1.3°) and 0.90 for IR (SEM, 1.9°), and the interrater reliability (ICC2,1) was 0.81 for ER (SEM, 3.3°) and 0.77 for IR (SEM, 4.3°). CONCLUSION: After a 40-pitch bullpen session, IR and ER PROM as well as total rotational motion were significantly lower than prepitching values; however, these deficits were restored back to their prepitching levels after the players performed the two-out drill, which may increase pitching performance and decrease the risk of shoulder and elbow injuries. More research is needed to test these hypotheses and assess the clinical efficacy of the two-out drill. CLINICAL RELEVANCE: The findings from the current study will assist clinicians better understand the positive effects of performing a short duration stretching/calisthenics drill on shoulder internal and external rotation range of motion between innings while pitching during a baseball game.

HSV-mediated delivery of erythropoietin restores dopaminergic function in MPTP-treated mice.

To investigate the neuroprotective effects of erythropoietin (EPO) in a rodent model of Parkinson disease, we inoculated a nonreplicating herpes simplex virus-based vector expressing EPO (vector DHEPO) into the striatum of mice 1 week prior to, or 2 weeks after, the start of continual administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (4 mg/kg intraperitoneally, 5 of 7 days) for 6 weeks. Inoculation with DHEPO prior to MPTP intoxication preserved behavioral function measured by pellet retrieval and the histological markers of tyrosine hydroxylase-immunoreactive (TH-IR) neuronal cell bodies in the substantia nigra (SN) and TH-IR and dopamine transporter-immunoreactive (DAT-IR) terminals in striatum. Inoculation of DHEPO 2 weeks into a 6-week course of MPTP resulted in improvement of behavioral function and restoration of TH-IR cells in SN and TH- and DAT-IR in the striatum. The effects of vector-produced EPO were similar in magnitude to the effects of vector-mediated expression of glial-derived neurotrophic factor in the same model. These results demonstrate that vector-mediated EPO production may be used to reverse dopaminergic neurodegeneration in the face of continued toxic insult.