A cross sectional study exploring factors impacting recruitment of African American college students into the genetic counseling profession.

African Americans account for about 12.7% of the United States population, but only 1% of the National Society of Genetic Counselors' membership identifies as African American. Since individuals often seek health care from providers sharing similar backgrounds, training genetic counselors from diverse backgrounds is critical. Psychology and biology students (N=552) at four universities completed a self-administered online survey assessing the influence of genetic counseling awareness, demographics, and career decisions on students' interest in pursuing genetic counseling as a career. More African Americans (83%) than Caucasians (62%) reported having chosen a career (p< or = .001). Of the 65% of students who indicated interest in the career description of genetic counseling, fewer African Americans (50%) than Caucasians (74%) had heard of genetic counseling (p< or = .001). Specific strategies to overcome recruiting barriers such as early career selection and lack of awareness of the genetic counseling career among African Americans are suggested.

Large neutral amino acids auto exchange when infused by microdialysis into the rat brain: implication for maple syrup urine disease and phenylketonuria.

Maple syrup urine disease (MSUD) and phenylketonuria (PKU) are associated with accumulation of large neutral amino acids (LNAA) in blood and tissues and a decrease of other LNAA not directly related to the enzyme defects. One characteristic shared by both the elevated and decreased amino acids is that all are substrates for transport via the large neutral amino acid transporter. In this study, the blood brain barrier was effectively bypassed using microdialysis to determine the immediate effect of infused phenylalanine, tyrosine, 2-amino-2-norborane-carboxylic acid (BCH), and leucine and alpha-ketoisocaproate on extracellular levels of LNAA. The concentration of non-infused LNAA increased in the interstitial fluid, presumably due to trans-stimulated exchange of these LNAA from intracellular pools as the infused LNAA entered the cells. Such trans-stimulated exchange can potentially deplete cells of multiple essential LNAA. It is proposed that brain cells in disorders such as MSUD and PKU may be subject to two mechanisms that limit the availability of a full complement of these amino acids: competition for transport of LNAAs at the blood brain barrier and trans-stimulated exchange out of neuronal cells for subsequent metabolism or sequestration in the periphery.