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2.
Phys Rev Lett ; 121(11): 112701, 2018 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-30265109

RESUMO

The ^{36}Ar(n,γ)^{37}Ar (t_{1/2}=35 d) and ^{38}Ar(n,γ)^{39}Ar (269 yr) reactions were studied for the first time with a quasi-Maxwellian (kT∼47 keV) neutron flux for Maxwellian average cross section (MACS) measurements at stellar energies. Gas samples were irradiated at the high-intensity Soreq applied research accelerator facility-liquid-lithium target neutron source and the ^{37}Ar/^{36}Ar and ^{39}Ar/^{38}Ar ratios in the activated samples were determined by accelerator mass spectrometry at the ATLAS facility (Argonne National Laboratory). The ^{37}Ar activity was also measured by low-level counting at the University of Bern. Experimental MACS of ^{36}Ar and ^{38}Ar, corrected to the standard 30 keV thermal energy, are 1.9(3) and 1.3(2) mb, respectively, differing from the theoretical and evaluated values published to date by up to an order of magnitude. The neutron-capture cross sections of ^{36,38}Ar are relevant to the stellar nucleosynthesis of light neutron-rich nuclides; the two experimental values are shown to affect the calculated mass fraction of nuclides in the region A=36-48 during the weak s process. The new production cross sections have implications also for the use of ^{37}Ar and ^{39}Ar as environmental tracers in the atmosphere and hydrosphere.

3.
Rev Sci Instrum ; 85(2): 02A901, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24593480

RESUMO

Beams of ions from the laser ablation method of solid materials into an electron cyclotron resonance ion source (ECRIS) plasma have been used for the first time in experiments at ATLAS. Initial accelerator mass spectroscopy experiments using laser ablation for actinides and samarium have been performed. Initial results of coupling the laser system to the ECR source have guided us in making a number of changes to the original design. The point of laser impact has been moved off axis from the center of the ECR injection side. Motor control of the laser positioning mirror has been replaced with a faster and more reliable piezo-electric system, and different raster scan patterns have been tested. The use of the laser system in conjunction with a multi-sample changer has been implemented. Two major problems that are being confronted at this time are beam stability and total beam intensity. The status of the development will be presented and ideas for further improvements will be discussed.

4.
Science ; 335(6076): 1614-7, 2012 03 30.
Artigo em Inglês | MEDLINE | ID: mdl-22461609

RESUMO

The extinct p-process nuclide (146)Sm serves as an astrophysical and geochemical chronometer through measurements of isotopic anomalies of its α-decay daughter (142)Nd. Based on analyses of (146)Sm/(147)Sm α-activity and atom ratios, we determined the half-life of (146)Sm to be 68 ± 7 (1σ) million years, which is shorter than the currently used value of 103 ± 5 million years. This half-life value implies a higher initial (146)Sm abundance in the early solar system, ((146)Sm/(144)Sm)(0) = 0.0094 ± 0.0005 (2σ), than previously estimated. Terrestrial, lunar, and martian planetary silicate mantle differentiation events dated with (146)Sm-(142)Nd converge to a shorter time span and in general to earlier times, due to the combined effect of the new (146)Sm half-life and ((146)Sm/(144)Sm)(0) values.

5.
Phys Rev Lett ; 94(9): 092504, 2005 Mar 11.
Artigo em Inglês | MEDLINE | ID: mdl-15783960

RESUMO

The 62Ni(n,gamma)63Ni(t(1/2)=100+/-2 yr) reaction plays an important role in the control of the flow path of the slow neutron-capture (s) nucleosynthesis process. We have measured for the first time the total cross section of this reaction for a quasi-Maxwellian (kT=25 keV) neutron flux. The measurement was performed by fast-neutron activation, combined with accelerator mass spectrometry to detect directly the 63Ni product nuclei. The experimental value of 28.4+/-2.8 mb, fairly consistent with a recent calculation, affects the calculated net yield of 62Ni itself and the whole distribution of nuclei with 62

6.
Phys Rev Lett ; 89(13): 132501, 2002 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-12225019

RESUMO

Scattering of alpha particles from 44Ti, the lightest unstable alpha-particle nucleus above A=40, has been measured at backward angles. The "anomalous" order-of-magnitude enhancement that is characteristic of 40Ca and other light alpha-particle nuclei is not observed. Instead, the backward yield is similar to that observed for other nuclei heavier than 40Ca, and is well described with average optical model parameters.

7.
Phys Rev Lett ; 89(5): 052701, 2002 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-12144438

RESUMO

The excitation function for fusion evaporation in the (60)Ni+ (89)Y system was measured over a range in cross section covering 6 orders of magnitude. The cross section exhibits an abrupt decrease at extreme sub-barrier energies. This behavior, which is also present in a few other systems found in the literature, cannot be reproduced with present models, including those based on a coupled-channels approach. Possible causes are discussed, including a dependence on the intrinsic structure of the participants.

8.
J Pharmacol Exp Ther ; 272(2): 681-8, 1995 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-7853182

RESUMO

Nonadrenergic imidazoline binding sites (imidazoline I2 sites) have been described to be colocated with monoamine oxidase (MAO) in the mitochondrial fraction of various cell types. In the present work, the authors considered whether this colocation could be associated with a functional interplay. In rat liver membranes, [3H]-idazoxan binding to I2 receptors was competed for by naphazoline and idazoxan, which also shared a high affinity for alpha-2 adrenoceptors (alpha-2 ARs). The chemicals 2-n-heptylimidazoline (S 15430), 1-methyl-5-n-heptylimidazole (S 15674), 2-benzofuran-2-yl-imidazoline (RX 801077) and 2-(1,3-benzodioxanyl)-2-imidazoline (RX 821029) exhibited higher affinity for I2 receptors than for alpha-2 ARs. The most selective agent was S 15430 with a 150-fold higher affinity for liver I2 receptors than for adipocyte alpha-2 ARs. Moreover, [3H]-idazoxan binding was also competed for by several MAO inhibitors (MAOI) that are not imidazoline or guanidinium derivatives such as tranylcypromine, harmaline, clorgiline and pargyline. Rat liver MAO activity was not only inhibited by MAOIs but also by some imidazoline derivatives: cirazoline, naphazoline, S 15674, RX 801077 and RX 821029. Idazoxan had no effect on MAO activity; it neither inhibited MAO nor prevented the inhibition induced by other imidazolines or MAOIs. This suggested that the ligand recognition site of I2 receptors was distinct from the MAOI target site. Furthermore, some imidazolines inhibited the activity of bovine plasma amine oxidase, an enzyme that does not possess the same cofactor as MAO and is insensitive to harmaline or pargyline.(ABSTRACT TRUNCATED AT 250 WORDS)


Assuntos
Amina Oxidase (contendo Cobre) , Imidazóis/farmacologia , Inibidores da Monoaminoxidase/farmacologia , Oxirredutases atuantes sobre Doadores de Grupo CH-NH/antagonistas & inibidores , Receptores de Droga/metabolismo , Animais , Sítios de Ligação , Ligação Competitiva , Cricetinae , Dioxanos/metabolismo , Idazoxano , Receptores de Imidazolinas , Masculino , Mesocricetus , Ratos , Ratos Wistar , Receptores Adrenérgicos alfa 2/efeitos dos fármacos
9.
Am J Physiol ; 266(3 Pt 2): R905-13, 1994 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-7909205

RESUMO

beta 3-Adrenoceptor agonists are potent lipolytic activators in rats, but they are only weak stimulators in human adipocytes, indicating interspecies differences in the adrenergic regulation of lipid mobilization. Like human but not rat adipocytes, guinea pig fat cells were poorly responsive to the beta 3-agonists BRL-37344, CGP-12177, SR-58611, and ICI-215001, acid metabolite of ICI-D7114. In guinea pigs, the beta 1-agonist dobutamine was more lipolytic than the beta 2-agonist procaterol. Anatomic location of fat deposits was without major influence on the beta-adrenergic responsiveness. Weak responses to beta 3-agonists were found whatever the sex or the age (from 2 days to 16 mo) of the animals. Even in the interscapular brown adipose tissue, which is well known in rats for its beta 3-adrenergic responsiveness, a blunted response to BRL-37344 was observed. The alpha 2-adrenergic antilipolytic effect and receptor number were smaller in guinea pig than in human adipocytes, but the beta-adrenergic receptor number was similar in the two species. Thus guinea pig adipocytes resemble human fat cells when their weak beta 3-adrenergic responsiveness is considered.


Assuntos
Adipócitos/metabolismo , Lipólise , Receptores Adrenérgicos beta/fisiologia , Receptores Adrenérgicos/fisiologia , Adipócitos/efeitos dos fármacos , Tecido Adiposo/metabolismo , Tecido Adiposo Marrom/metabolismo , Agonistas Adrenérgicos beta/farmacologia , Envelhecimento/metabolismo , Animais , Animais Recém-Nascidos , Feminino , Cobaias , Humanos , Masculino , Receptores Adrenérgicos alfa/metabolismo , Caracteres Sexuais
10.
J Pharmacol Exp Ther ; 265(1): 237-47, 1993 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-8097243

RESUMO

The beta-3 adrenoceptor protein lacks most of the potential phosphorylation sites for beta adrenoceptor kinase and protein kinase A. In addition, it exhibits a lower affinity toward norepinephrine than beta-1 or beta-2 adrenoceptors. It is thus expected that beta-3 adrenoceptors could be less implicated in desensitization processes than the beta-1 or beta-2 adrenoceptors. An attempt to demonstrate the physiological relevance of this prediction was performed by using fat cells having a beta-3 adrenergic responsiveness or not (hamster and guinea pig). The influence of prolonged in vivo exposure to norepinephrine on the beta adrenoceptor-mediated lipolytic responses was investigated in both species. In control guinea pigs, isoproterenol, norepinephrine and epinephrine were fully lipolytic, whereas BRL 37344 [(R',R')-4-2[2-((2[(3-chlorophenyl)-2-hydroxyethyl]amino] propyl)phenyl]phenoxyacetic acid], CGP 12177](+-)-4-(3-tertiarybutylamino-2-hydroxypropoxy)- benzimidazole-2-on hydrochloride] and other beta-3 agonists were inefficient, whereas hamster adipocytes exhibited maximal response to the beta-3 agonists. Blockade of the lipolytic effect of isoproterenol in the guinea pig gave a rank order of beta antagonists [CGP 20712A (1-[2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino]-3-4-(1-methyl-4-tr i-fluoro-methyl-1H-imidazol-2-yl)phenoxy-2-propanol methanesulfonate] > bupranolol > or = propranolol >> ICI 118551 [erythrodl-1-(7- methylindan-4-yloxy)-3-isopropylaminobutan-2-ol)] in agreement with that of a beta-1 effect. In contrast, the selective beta-1 antagonist CGP 20712A did not counteract the effect of BRL 37344 in hamsters and bupranolol was the best beta antagonist tested; a result arguing for the predominance of a beta-3 component in the adrenergic activation of lipolysis, as in rat fat cells. In treated guinea pigs (6-day treatment with osmotic minipumps delivering norepinephrine at the rate of 5 micrograms/min/kg), the adrenocorticotropic hormone dose-response curve was identical to that of controls, but the curves for isoproterenol, norepinephrine and epinephrine were flattened and shifted to the right. A down-regulation of beta-1 and beta-2 adrenoceptors was evidenced by a reduction in [3H]CGP 12177 high-affinity binding sites. In treated hamsters, compared to the controls, there was no change in the lipolytic response to the beta adrenergic agonists. Other protocols of chronic exposure to norepinephrine (e.g., daily injections) at different doses were also unable to reduce the beta-lipolytic effect in the hamster fat cells.(ABSTRACT TRUNCATED AT 400 WORDS)


Assuntos
Tecido Adiposo/efeitos dos fármacos , Norepinefrina/farmacologia , Receptores Adrenérgicos beta/efeitos dos fármacos , Tecido Adiposo/metabolismo , Agonistas Adrenérgicos beta/farmacologia , Hormônio Adrenocorticotrópico/farmacologia , Animais , Peso Corporal/efeitos dos fármacos , Cricetinae , Cobaias , Lipólise/efeitos dos fármacos , Mesocricetus , Norepinefrina/administração & dosagem , Receptores Adrenérgicos beta/metabolismo
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