An investigation into the efficacy of intravenous diclofenac in post-operative dental pain.

OBJECTIVE: To evaluate the efficacy of single doses of intravenous diclofenac sodium (25, 50 and 75 mg) in patients with post-operative pain after third-molar surgery in a randomised, placebo-controlled study. METHODS: Two hundred and sixty-nine patients (168 females) who required the removal of their impacted third molars participated in the study, which had received prior ethical approval. Surgery was completed under general anaesthesia and, during the early post-operative period, patients received either a single intravenous dose of diclofenac (25, 50 or 75 mg) or matched placebo in random, double-blind order. Pain intensity was assessed on 10-cm visual analogue scales at fixed time points throughout a 4-h investigation period. Other efficacy variables obtained included time until rescue medication and overall assessment at 4, 6, 12 and 24 h after dosing. RESULTS: Throughout the 4-h investigation period, patients treated with diclofenac reported significantly less pain than those treated with placebo (P < 0.001). No differences were observed among the three doses of diclofenac (P = 0.22). Similar results were observed at 6, 12 and 24 h after dosing. Significant differences were also noted between the placebo group and all the diclofenac treatment groups with respect to time until rescue medication (P < 0.001) and the proportion of patients taking such medication. CONCLUSION: Single doses of i.v. diclofenac (25, 50 and 75 mg) provide significant pain relief after third-molar surgery. The efficacy of this preparation does not appear to be dose related.

Effects of intermittent modelling on observational learning.

A large research literature suggests that modelling in the absence of reinforcement for either the model's or the observer's behavior is a potent source of social learning. This literature is based entirely, however, on experiments using models that always display the critical behaviors. It is possible, therefore, that results obtained in these experiments would not generalize to natural settings in which modelling is intermittent. The effects of intermittent modelling were examined using three groups of 15 four- and five-year-old children. Male and female children from middle-income families were individually exposed to an adult model who alternated descriptions of pictures of common objects. With one group, the model used no descriptive adjectives (color or number) in her descriptions after baseline; she used descriptive adjectives with 50% of the pictures with a second group, and 100% of the pictures with a third. Analyses of the data showed that the children substantially increased their use of descriptive adjectives in both modelling groups, but not in the no-modelling group. The fact that there were no significant differences between the 50% and 100% modelling groups suggests that results obtained in studies using consistent modelling can be generalized to natural settings.