1.
J Org Chem
; 89(12): 8773-8781, 2024 Jun 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38822797
RESUMO
The mono N-alkylation of arylamines using alkylamines as alkyl group donors has been scarcely investigated. In this work, we report the mono N-alkylation of several arylamines (52-95%) catalyzed by the complex ruthenium-triphos in the presence of Al(OTf)3. Moreover, the highly reductant ability of the catalyst system allows the tandem reduction/N-alkylation of nitrobenzenes in good yields (up to 80%). In addition, the catalyst can be recycled after three reaction cycles without loss of catalyst activity.