Humoral response after the fourth dose of the SARS-CoV-2 vaccine in the CKD spectrum: a prespecified analysis of the SENCOVAC study.

BACKGROUND: There is scarce evidence on the fourth dose of severe acute respiratory syndrome coronavirus 2 vaccines in chronic kidney disease (CKD) patients. We evaluated the humoral response and effectivity of the fourth dose in the CKD spectrum: non-dialysis CKD (ND-CKD), haemodialysis (HD), peritoneal dialysis (PD) and kidney transplant (KT) recipients. METHODS: This is a prespecified analysis of the prospective, observational, multicentric SENCOVAC study. In patients with CKD who had received a complete initial vaccination and one or two boosters and had anti-Spike antibody determinations 6 and 12 months after the initial vaccination, we analysed factors associated with persistent negative humoral response and higher anti-Spike antibody titres as well as the efficacy of vaccination on coronavirus disease 2019 (COVID-19) severity. RESULTS: Of 2186 patients (18% KT, 8% PD, 69% HD and 5% ND-CKD), 30% had received a fourth dose. The fourth dose increased anti-Spike antibody titres in HD (P = .001) and ND-CKD (P = .014) patients and seroconverted 72% of previously negative patients. Higher anti-Spike antibody titres at 12 months were independently associated with repeated exposure to antigen (fourth dose, previous breakthrough infections), previous anti-Spike antibody titres and not being a KT recipient. Breakthrough COVID-19 was registered in 137 (6%) patients, 5% of whom required admission. Admitted patients had prior titres <620 UI/ml and median values were lower (P = .020) than in non-admitted patients. CONCLUSIONS: A fourth vaccine dose increased anti-Spike antibody titres or seroconverted many CKD patients, but those with the highest need for a vaccine booster (i.e. those with lower pre-booster antibody titres or KT recipients) derived the least benefit in terms of antibody titres. Admission for breakthrough COVID-19 was associated with low anti-Spike antibody titres.

Analysis of sensorimotor control in people with and without neck pain using inertial sensor technology: study protocol for a 1-year longitudinal prospective observational study.

INTRODUCTION: Neck pain is a very common musculoskeletal disorder associated with high socioeconomic costs derived from work absenteeism and medical expenses. Previous studies have suggested that patients with neck pain of different origins present sensorimotor control impairments compared with the asymptomatic population. However, there is a small number of published studies focusing on these with conflicting results. In addition, the existing methodological limitations highlight the need for more and better quality studies. Moreover, longitudinal studies are necessary to investigate whether changes in pain or disability in individuals with chronic neck pain over time associate with changes in cervical sensorimotor control. METHODS AND ANALYSIS: This is a descriptive, observational, longitudinal, prospective study consecutively enrolling 52 patients with non-specific neck pain and 52 age-matched asymptomatic participants.Intensity of pain, neck disability, duration of symptoms, topography of pain and comorbidities will be registered at baseline. Sensorimotor control variables including active range of motion, movement speed, acceleration, smoothness of motion, head repositioning accuracy and motion coupling patterns will be recorded as primary outcomes by means of inertial sensors during the following tests consecutively performed in two sessions separated by 12 months: (1) kinematics of planar movements, (2) kinematics of the craniocervical flexion movement, (3) kinematics during functional tasks and (4) kinematics of task-oriented neck movements in response to visual targets.Secondary outcomes will include: (1) Regular physical activity levels, (2) Kinesiophobia, (3) Symptoms related to central sensitisation and (4) The usability of the inertial measurement unit sensor technology. ETHICS AND DISSEMINATION: This study was approved by the Research Ethics Committee of CEU San Pablo University (495/21/39). Patients will be recruited after providing written informed consent and they will be able to withdraw their consent at any time. Only the study investigators will have access to the study data. The results will be disseminated through scientific publications, conferences and media. TRIAL REGISTRATION NUMBER: NCT05032911.

Predictores de la intención de consumo intensivo episódico de alcohol en adolescentes

El consumo intensivo episódico (CIEA) constituye un problema de salud pública que afecta a los más jóvenes. El estudio de los determinantes cognitivo motivacionales de este patrón de consumo es un área reciente y en creciente desarrollo. Una de las teorías que se ha mostrado adecuada para la explicación de esta conducta es la Teoría del Comportamiento Planeado (TCP). Este trabajo tiene como objetivo estudiar la relación entre la intención de CIEA, la actitud, la norma subjetiva y la percepción de control conductual en estudiantes secundarios diferenciándolos por género. Método: La muestra fue intencional, de estudiantes secundarios (n = 185) de la ciudad de Mar del Plata (Argentina) de 12-18 años. Se utilizó un cuestionario que indagaba sobre: patrones de consumo, variables de la TCP, edad y sexo. Se realizaron análisis de regresión jerárquica para varones y mujeres por separado, considerando la intención como variable dependiente. Resultados: La principal variable que predice la intención de CIEA, tanto para varones como mujeres es la actitud. La norma subjetiva resultó predictora únicamente en mujeres. Conclusiones: las creencias y evaluaciones respecto al CIEA juegan un importante papel en la disposición para realizar el comportamiento. En el caso de las mujeres también incide la norma subjetiva. Si bien este estudio posee algunas limitaciones, sus resultados permiten aproximarse al estudio de los factores cognitivos motivacionales relacionados con el CIEA en adolescentes, de acuerdo al género.(AU)

Binge drinking (BD) is a public health problem that affects younger people. The study of cognitive motivational determinants of this consumption pattern is a growing and recently developed area. One theory that has proved to be adequate for the explanation of this behavior is the Theory of Planned Behavior (TPB). This paper aims to study the relationship between BD intention, attitude, subjective norm and perceived behavioral control in high school students, by gender. Method: The sampling was intentional, comprising high school students (n = 185) of the city of Mar del Plata (Argentina) from 12 -18 years old. A questionnaire was developed inquiring about: habitual consumption pattern, TPB variables, age and gender. Hierarchical regression analyses were conducted for men and women separately, considering intention as the dependent variable. Results: The main variable that predicted intention of BD, for both, males and females, was the attitude. The subjective norm was a predictor only in females. Conclusions: Beliefs and evaluations regarding the BD play a significant role in the disposition for the behavior. For females, subjective norms also affected intention of BD. While this study had some limitations, results highlight the importance of the study of cognitive motivational factors related to BD in adolescents by gender.(AU)

Predictores de la intención de consumo intensivo episódico de alcohol en adolescentes / Binge drinking intention predictors in adolescents

El consumo intensivo episódico (CIEA) constituye un problema de salud pública que afecta a los más jóvenes. El estudio de los determinantes cognitivo motivacionales de este patrón de consumo es un área reciente y en creciente desarrollo. Una de las teorías que se ha mostrado adecuada para la explicación de esta conducta es la Teoría del Comportamiento Planeado (TCP). Este trabajo tiene como objetivo estudiar la relación entre la intención de CIEA, la actitud, la norma subjetiva y la percepción de control conductual en estudiantes secundarios diferenciándolos por género. Método: La muestra fue intencional, de estudiantes secundarios (n = 185) de la ciudad de Mar del Plata (Argentina) de 12-18 años. Se utilizó un cuestionario que indagaba sobre: patrones de consumo, variables de la TCP, edad y sexo. Se realizaron análisis de regresión jerárquica para varones y mujeres por separado, considerando la intención como variable dependiente. Resultados: La principal variable que predice la intención de CIEA, tanto para varones como mujeres es la actitud. La norma subjetiva resultó predictora únicamente en mujeres. Conclusiones: las creencias y evaluaciones respecto al CIEA juegan un importante papel en la disposición para realizar el comportamiento. En el caso de las mujeres también incide la norma subjetiva. Si bien este estudio posee algunas limitaciones, sus resultados permiten aproximarse al estudio de los factores cognitivos motivacionales relacionados con el CIEA en adolescentes, de acuerdo al género.

Binge drinking (BD) is a public health problem that affects younger people. The study of cognitive motivational determinants of this consumption pattern is a growing and recently developed area. One theory that has proved to be adequate for the explanation of this behavior is the Theory of Planned Behavior (TPB). This paper aims to study the relationship between BD intention, attitude, subjective norm and perceived behavioral control in high school students, by gender. Method: The sampling was intentional, comprising high school students (n = 185) of the city of Mar del Plata (Argentina) from 12 -18 years old. A questionnaire was developed inquiring about: habitual consumption pattern, TPB variables, age and gender. Hierarchical regression analyses were conducted for men and women separately, considering intention as the dependent variable. Results: The main variable that predicted intention of BD, for both, males and females, was the attitude. The subjective norm was a predictor only in females. Conclusions: Beliefs and evaluations regarding the BD play a significant role in the disposition for the behavior. For females, subjective norms also affected intention of BD. While this study had some limitations, results highlight the importance of the study of cognitive motivational factors related to BD in adolescents by gender.

Glomerulonefritis membranosa, psoriasis y etanercept. ¿Asociación casual o causal? / Membranous glomerulonephritis, psoriasis and etanercept. A chance or causal association?

La psoriasis es una enfermedad cutánea con afectación sistémica, cuyo daño tisular se considera inmunomediado y que en la actualidad se trata eficazmente con etanercept. El daño renal de esta patología no está completamente aclarado en la literatura. Presentamos un caso de glomerulonefritis membranosa con depósitos de C1q que posteriormente desarrolló psoriasis. En este artículo hacemos una revisión de la posible asociación entre estas patologías y la respuesta a esta molécula biológica (AU)

Psoriasis is a cutaneous disease with systemic involvement. Tisular damage is consider to be immunomediated, and actually is being effectively treated with Etanercept. Kidney damage of this patological condition is not completely clarified in the literature. We present a case of Membranous Nephropathy with C1q deposits that subsequently developed psoriasis. In this article we make a review of a possible association between these diseases and the respose to that biological molecule (AU)

Membranous glomerulonephritis, psoriasis and etanercept. A chance or causal association?

Psoriasis is a cutaneous disease with systemic involvement. Tissue damage is considered to be immune-mediated, and etanercept currently provides effective treatment. Kidney injury arising from this condition has not yet been fully explained in the literature. We present a case of membranous nephropathy with C1q deposits followed by development of psoriasis. In this article we will review the possible association between these conditions and the response to this biological molecule.

Valor pronóstico de la glicemia al ingreso en pacientes críticos con patologías neurológicas / Prognostic value of the blood glucose levels at the moment of admission in critical patients discharged with neurological pathology

Evaluamos lo que sucedió en nuestros pacientes con patología neurológica, no diabéticos, en cuanto al nivel de sus cifras de glicemia durante las primeras 24 horas de su ingreso a UTI, y si éstas tienen relación con la gravedad, evolución y mortalidad en este grupo de 226 pacientes. Encontramos en los egresados vivos, una media de glicemia de 151,72 mgrs por ciento Vs. 244,06 mgrs por ciento, en los fallecidos, lo cual fue estadísticamente significativo. El análisis estadístico estableció un valor crítico de 198 mgrs por ciento, por encima del cual, la probabilidad de muerte aumenta significativamente, logrando clasificar correctamente el 82 por ciento de los casos, en virtud de lo cual pensamos que cualquier medida terapéutica que contribuya a mantener la glicemia dentro de los valores normales en este grupo de pacientes será necesaria y está plenamente justificada.