[Liposarcoma of spermatic cord. A rare urologic tumor]. / Liposarcoma de cordón espermático. Un raro tumor urológico.

Malignant paratesticular tumors are uncommon. Of these, liposarcoma of the spermatic cord constitutes a rare tumor type with a good prognosis. It has a high rate of survival over 5 years. Inguinal orchiectomy generally suffices, although patients should be followed closely since local recurrence is not uncommon. The present study briefly reviews the literature on spermatic cord liposarcoma and reports an additional case that was treated exclusively by radical orchiectomy. Four years postoperatively the patient continues to be tumor-free.

Inclusion body myofibroblasts other than those seen in recurring digital fibroma of childhood.

Four patients of the toxic oil epidemic syndrome (TOES), which took place in Spain in 1981, showed a dermohypodermal fibroblastic process with round eosinophilic cytoplasmic inclusions (ECI) in the proliferating cells. Light and electron microscopic studies revealed that those cells had myofibroblastic features and that the ECI were identical to those seen in recurring digital fibroma of childhood (RDFC). Two cases of RDFC, involving the fingers of 6-month-old and 2-year-old patients, were examined by light and electron microscopy for comparative study. The 4 patients of TOES, aged 14 to 46 years, showed generalized sclerodermalike skin changes, and skin biopsies were obtained from the anterior wall of the abdomen and retromaleolar region of the left leg. The ultrastructural study of the ECI and the initiating changes leading to them allowed us to suggest a cytoskeletal origin for these inclusions.

Pathology of a new toxic syndrome caused by ingestion of adulterated oil in Spain.

The Toxic Syndrome (TS) caused by ingestion of adulterated rapeseed oil in Spain is a new disease of multisystemic character whose aetiology and pathogenesis remains unknown. The most prominent pathological feature is a peculiar non-necrotizing vasculitis, that affects mainly the intima and involves vessels of every type and size in practically every organ. The TS begins with an acute clinical picture with pleuropneumopathy, fever, headaches, exanthems and eosinophilia. In these early clinical phases the main pathological findings were observed in the lungs and consisted of intense pulmonary interstitial oedema with scanty inflammatory mononuclear infiltrates. Ultrastructural study revealed hydropic degeneration of pneumocytes types I and II with desquamation of type I. The patients in this phase died of respiratory failure, later deaths were due to thromboembolic complications. Later still the patients developed a neuromuscular syndrome, sclerodermiform skin lesions and severe weight loss and died predominantly of infectious complications and respiratory failure. The anatomopathological picture in the peripheral nerves was that of inflammatory neuropathy with a lymphocytic perineuritis that led to perineural fibrosis with secondary axonal degeneration. The muscle presented an interstitial inflammatory myopathy at first followed by a neurogenic muscular atrophy. The skin lesions in the late phases consisted in dermal or dermal and subdermal fibrosclerosis, with vasculitis of the small arteries in the lower dermis. The salivary glands and pancreas showed vasculitis and interstitial inflammation which progressed to interstitial fibrosis and parenchymal atrophy.